{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:11:25Z","timestamp":1778850685041,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":5303,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic> The relationship between stillbirths and infections during pregnancy.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>, Antibodies to 13 different viruses and to <jats:italic>Mycoplasma pneumoniae, Treponema pallidum, Toxoplasma gondii<\/jats:italic>, and <jats:italic>Chlamydia trachomatis, psittaci, and pneumoniae<\/jats:italic> were studied from sera of 42 mothers with stillbirth and of matched case\u2010control pregnancies.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Elevated antibody levels to <jats:italic>Chlamydia trachomatis<\/jats:italic> and human parvovirus B19 were observed in seven mothers with stillbirth as compared with one in matched case controls (<jats:italic>p<\/jats:italic>\u20100.03 and p&lt;0.06, Fisher's exact one\u2010 and two\u2010tailed <jats:italic>p<\/jats:italic> values). By a novel EIA test for <jats:italic>C. trachomatis<\/jats:italic>, based on synthetic polypeptide, 15 positive cases were detected in patients compared to seven in controls. Placental calcifications and fetal growth retardation appeared more often (<jats:italic>p<\/jats:italic>&lt;0.001 and <jats:italic>p<\/jats:italic>&lt;0.05, respectively) in the <jats:italic>C. trachomatis<\/jats:italic>\u2010 associated cases than in the others. There was no significant relation between stillbirth and the other antibodies.<\/jats:p><jats:p><jats:italic>Conclusions.<\/jats:italic> We suggest <jats:italic>C. trachomatis<\/jats:italic> as a hitherto unrecognized possible cause of stillbirths besides human parvovirus B19. A new EIA test for <jats:italic>C. trachomatis<\/jats:italic>, one covering all strains, is promising and makes the future assays more convenient, and may thus make it possible to reduce the rate of stillbirths.<\/jats:p>","DOI":"10.3109\/00016349609054693","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:48:59Z","timestamp":1195692539000},"page":"657-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Stillbirths and maternal antibodies to <i>Chlamydia trachomatis.<\/i> A new EIA test for serology"],"prefix":"10.1111","volume":"75","author":[{"given":"Marjaleena","family":"Koskiniemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirkko","family":"\u00c4mm\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ale","family":"N\u00e4rv\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Saikku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"S\u00f6derlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pentti","family":"Koskela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Laurila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Vaheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.14.5.313"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1983.tb09296.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198701223160403"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6733.1166"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03370240044034"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1001\/jama.1986.03380140069024","article-title":"Independent associations of bacterial vaginosis and C. trachomatis infection with adverse pregnancy outcome","volume":"256","author":"Graven M. 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