{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:05:24Z","timestamp":1758121524598},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":5241,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> Interleukin\u20108 (IL\u20108) has an essential role in the mechanism of parturition. IL\u20108 induces its effect through specific cell binding receptors. The main purpose of this research was to elucidate the presence of IL\u20108 receptors in the gestational tissues and their relation to parturition.<\/jats:p><jats:p><jats:italic>Materials and methods.<\/jats:italic> Fetal membranes, placenta, umbilical cord and myometrial samples were collected before the initiation of labor during elective Cesarean sections (<jats:italic>n<\/jats:italic>=15). Similar biopsies (except myometrial samples) were also gathered after normal vaginal delivery (<jats:italic>n<\/jats:italic>= 15). Immunohistochemical staining for IL\u20108 receptors type I and II was carried out for the fresh frozen sections of all samples. Immunoreactive score (IRS) was calculated for the stained sections.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> IL\u20108 Receptors type I and II were recognized in the fetal membranes, placenta, umbilical cord and myometrial samples collected from patients before the initiation of labor. The staining of amnion and placentas were found to be more intensified in the samples collected after vaginal delivery compared to those from elective cesarean sections and before initiation of labor.<\/jats:p><jats:p><jats:italic>Conclusions.<\/jats:italic> Increased expression of IL\u20108 receptors after initiation of labor may indicate that IL\u20108 receptors might have a role during parturition.<\/jats:p>","DOI":"10.3109\/00016349609054705","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:49:22Z","timestamp":1195692562000},"page":"790-796","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Expression of interleukin\u20108 receptors in the gestational tissues before and after initiation of labor: Immunohistochemical study"],"prefix":"10.1111","volume":"75","author":[{"given":"Emad El","family":"Maradny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiro","family":"Kanayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Terao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","volume-title":"The cervix in pregnancy and labor, clinical and biochemical investigations","author":"Liggins G. 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