{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:19:18Z","timestamp":1759479558706,"version":"3.41.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[1997,8,31]],"date-time":"1997-08-31T00:00:00Z","timestamp":872985600000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To define a simple, safe and reliable program for the monitoring of anti\u2010D alloimmunized pregnancies by analysis of the covariation between antenatal values of the titer and the concentration of anti\u2010D antibodies in maternal serum, the AOD<jats:sub>450 nm<\/jats:sub> in amniotic fluid samples, and the levels of B\u2010hemoglobin and S\u2010bilirubin in the newborns at birth.<\/jats:p><jats:p><jats:italic>Subjects<\/jats:italic>. Ninety\u2010three Rh(D) negative women with anti\u2010D antibody titers \u2265 16 who, after the completed 34th gestational week, gave birth to Rh(D) positive babies with a positive direct antiglobulin test.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. The titers and the concentrations of anti\u2010D antibodies in maternal serum were determined by standard procedures every second week from the 25th week of gestation. In 47 of the 93 women, \u0394OD<jats:sub>450 nm<\/jats:sub> in amniotic fluid was determined at least once. All antenatal values used in the study were determined within 14 days before delivery.<\/jats:p><jats:p><jats:italic>Results and conclusion<\/jats:italic>. Maternal serum antibody titers \u226432 or \u22651000 could in themselves well predict unaffected and affected newborns. Antibody titers between 64 and 512 could not accurately predict newborns with or without hemolytic disease. As a complementary monitoring test, determination of the \u0394OD<jats:sub>450 nm<\/jats:sub> was found to be less accurate when compared to determination of the concentration of anti\u2010D antibodies.<\/jats:p><jats:p>In order to monitor Rh(D) alloimmunized pregnancies, determination of the concentration of anti\u2010D antibodies may possibly replace determination of \u0394OD<jats:sub>450 nm<\/jats:sub>.<\/jats:p>","DOI":"10.3109\/00016349709024338","type":"journal-article","created":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T13:06:57Z","timestamp":1205413617000},"page":"733-738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Concentration of anti\u2010D antibodies in Rh(D) alloimmunized pregnant women, as a predictor of anemia and\/or hyperbilirubinemia in their newborn infants"],"prefix":"10.1111","volume":"76","author":[{"given":"Tomas","family":"Gottvall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Olof","family":"Hllden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,8,31]]},"reference":[{"issue":"1","key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0308-2261(21)00015-1","article-title":"Observations on Rh iso\u2010immunization: past, present and future","volume":"5","author":"Frazer I. 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