{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:49:23Z","timestamp":1785761363568,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[1997,8,31]],"date-time":"1997-08-31T00:00:00Z","timestamp":872985600000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> A comparison of ethacridine lactate and prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) with or without oxytocin infusion in second trimester medical abortion cases.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> A prospective study was performed on 151 women requiring second trimester medical abortions between 1989 and 1995. Patients were randomly assigned to PGE<jats:sub>2<\/jats:sub> group (<jats:italic>n<\/jats:italic>= 30), ethacridine lactate group (<jats:italic>n<\/jats:italic>48), ethacridine lactate combined with oxytocin infusion group (<jats:italic>n<\/jats:italic>=49) and PGE<jats:sub>2<\/jats:sub> combined with oxytocin infusion group (<jats:italic>n<\/jats:italic>=24). Rates of successful abortion (i.e., complete evacuation of fetal and placental tissxies from the uterus) within 24 hours for each group were determined and compared by x<jats:sup>2<\/jats:sup> and the Student r\u2010test.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Statistically significant difference concerning successful abortion rates was observed between ethacridine lactate and PGE<jats:sub>2<\/jats:sub> groups, PGE<jats:sub>2<\/jats:sub> and PGE<jats:sub>2<\/jats:sub>+oxytocin infusion groups, and ethacridine lactate+oxytocin infusion and PGE<jats:sub>2<\/jats:sub> groups, while there was no significant difference between ethacridine lactate and ethacridine lactate+oxytocin infusion groups, ethacridine lactate and PGE<jats:sub>2<\/jats:sub>+oxytocin infusion groups, and PGE<jats:sub>2<\/jats:sub>+oxytocin infusion and ethacridine lactate+oxytocin infusion groups.<\/jats:p><jats:p><jats:italic>Conclusions.<\/jats:italic> Extra\u2010amniotic ethacridine lactate instillation alone and intracervical PGE<jats:sub>2<\/jats:sub> gel application are effective and safe methods for second trimester abortion.<\/jats:p>","DOI":"10.3109\/00016349709024610","type":"journal-article","created":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T13:06:12Z","timestamp":1205413572000},"page":"680-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of ethacridine lactate and prostaglandin E<sub>2<\/sub> in second trimester medical abortion"],"prefix":"10.1111","volume":"76","author":[{"given":"Ismet","family":"Inan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefa","family":"Kelek\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Yazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1997,8,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3552(05)80193-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348709015733"},{"key":"e_1_2_1_4_1","first-page":"24","article-title":"Interruption of pregnancy by extra\u2010ovular instillation of a solution","volume":"1","author":"Kashiwara N.","year":"1949","journal-title":"Sanfu, Shinpo"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0002-9378(71)90214-6","article-title":"Extraovular transcervical injection of Rivanol for interruption of pregnancy","volume":"110","author":"Nabriski S. 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Trimenon. [Use of prostaglandins in pregnancy termination in the 1st and 2nd trimester.] (In German with English abstract.)","volume":"99","author":"Rath W.","year":"1987","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00931546"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.1989.tb07829.x"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349709024610","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349709024610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T07:00:11Z","timestamp":1749452411000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349709024610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["10.3109\/00016349709024610"],"URL":"https:\/\/doi.org\/10.3109\/00016349709024610","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8]]},"assertion":[{"value":"1997-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}