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We wanted to identify elements of antenatal care which are of proven benefit in preventing or ameliorating specific adverse outcomes in the mother: bleeding, anemia, preeclampsia, sepsis and genito\u2010urinary infection and obstructed labor. <jats:italic>Methods.<\/jats:italic> Review of recent literature, especially randomized controlled trials. <jats:italic>Results and conclusions.<\/jats:italic> Recent trials indicate that fewer routine visits for low\u2010risk women do not put pregnancies at increased risk but may lessen patient satisfaction. Bleeding in pregnancy has many causes, none of which can be eliminated through antenatal care. Risk factors can be identified by history\u2010taking. Counselling and advice on what to do is the best option. Anemia in pregnancy is common, especially in developing countries. Routine iron supplementation is not necessary in well\u2010nourished populations, but iron and folate should be provided for every pregnant woman in areas of high anemia prevalence; based on circumstantial evidence. Hemoglobin (Hb) determination as a routine test is more important late (around week 30) than early in pregnancy: high Hb is a danger signal. It is uncertain whether early detection of pre\u2010eclampsia will reduce the incidence of eclampsia. Recent trials do not support routine aspirin to prevent pre\u2010eclampsia among low risk women, nor is there evidence that anti\u2010hypertensive treatment of mild pre\u2010eclampsia will prevent more severe disease, but improved detection and care may still lead to better outcome. As to infections, urine culture and dipstick for leucocyte esterase and nitrite with subsequent treatment of positive cases will reduce the risk of pyelonephritis and appears to be cost\u2010effective. Serological screening and treatment of syphilis is inexpensive and cost\u2010effective. Obstructed labor can be anticipated in multiparas based on obstetrical history. Hospital delivery should be secured. Height of nulli\u2010paras should be recorded where hospital birth is not routine and a discriminatory level for hospital delivery decided locally. External version of breech lie does reduce the incidence of breech births and cesarean delivery.<\/jats:p>","DOI":"10.3109\/00016349709047778","type":"journal-article","created":{"date-parts":[[2008,3,5]],"date-time":"2008-03-05T19:04:58Z","timestamp":1204743898000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":145,"title":["Scientific basis for the content of routine antenatal care I. 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