{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:13:11Z","timestamp":1793812391227,"version":"4.6.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1997,5,31]],"date-time":"1997-05-31T00:00:00Z","timestamp":865036800000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:p>Background. The role of progesterone levels during human labor is unclear.<\/jats:p><jats:p>Objective. To investigate serum concentrations of progesterone and 5\u03b1\u2010pregnane\u20103,20\u2010dione in normal and abnormal deliveries.<\/jats:p><jats:p>Methods. Venous and umbilical cord serum samples were collected from 108 parturient women. In a further 49 deliveries, arterial and venous umbilical cord sera were collected separately. The concentrations of progesterone and 5opregnane\u20103,20\u2010dione were determined by radioimmunoassay. The delivery modes studied were: elective cesarean section; oxytocin\u2010resistant dystocia; normal but induced delivery, and normal spontaneous delivery.<\/jats:p><jats:p>Results. Progesterone concentrations in maternal and umbilical serum were higher following normal labor than after dystocia (p&lt;0.005) and elective cesarean section (p&lt;0.005). The maternal and umbilical progesterone concentrations in dystocia and elective cesarean section were between 77\u201343 % of those in normal labor. The concentrations did not vary between gestational weeks 37 and 42, within the different modes of delivery. The 5\u03b1\u2010pregnane\u20103,20\u2010dione serum concentration in the fetal compartment was twice that in the maternal compartment (p&lt;0.001); its concentration in venous umbilical serum was higher than in corresponding arterial samples (p&lt;0.001). No distinct differences in the 5\u03b1\u2010pregnane\u20103,20\u2010dione serum concentration were found with regard to parity or mode of delivery.<\/jats:p><jats:p>Conclusion. High progesterone concentrations during parturition appear to be related to effective labor. 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