{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:49:38Z","timestamp":1777412978111,"version":"3.51.4"},"reference-count":83,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>Early intervention into prodromal schizophrenia has shown promise, but controversy continues regarding the ethical acceptability of identifying a group of \u2018ultra high risk\u2019 individuals of whom only 30 to 50% will develop a psychotic disorder. With well developed early intervention services this group faces the possibility of being labelled as \u2018pre-psychotic\u2019, a condition for which the well known stigma associated with the diagnosis of schizophrenia or bipolar disorder is likely to be associated. In addition, the use of potent antipsychotic and other medications (albeit usually at lower doses than those used for those with manifest psychosis) mandates consideration of the risks associated with their use and neurological and metabolic side effects. The potential for iatrogenic morbidity in the \u2018false positive\u2019 group must be weighed against the need of the \u2018true positives\u2019 identified through screening and assessment. Current evidence for the concept of \u2018at-risk mental state\u2019 was reviewed within a neurodevelopmental framework, including emerging data on the effectiveness of early intervention for the purpose of providing recommendations for community mental health services. The review suggests that different treatment strategies may be appropriate depending on the clinical stage of the condition as long as the benefits of intervention outweigh its risk burden. It further suggests that the severity of psychoses and the evidence of its early onset in utero and its acceleration in adolescence positions \u2018ultra high risk\u2019 intervention as a core model for early intervention for young people by teasing apart the symptomatic components of the \u2018prepsychotic state\u2019 and ensuring the population is reaching targeted mental health services for screening. The model is not restricted to the delivery of intervention for \u2018pre-psychotic\u2019 young people but is applicable for targeted programmes for a number of clinical groups considered at \u2018ultra high risk\u2019. However, only further research in naturalistic populations embedded in clinical practice and ideally conducted in partnership of mental health services with academic research institutions will help clarify potential risks of early identification and intervention and assist in updating and making more explicit the clinical guidelines services will use in approaching those in the \u2018ultra high risk\u2019 group.<\/jats:p>","DOI":"10.3109\/00048674.2010.493857","type":"journal-article","created":{"date-parts":[[2010,10,10]],"date-time":"2010-10-10T17:44:19Z","timestamp":1286732659000},"page":"872-882","source":"Crossref","is-referenced-by-count":8,"title":["Young Rural People at Risk for Schizophrenia: Time for Mental Health Services to Translate Research Evidence into Best Practice of Care"],"prefix":"10.1177","volume":"44","author":[{"given":"Helen J.","family":"Stain","sequence":"first","affiliation":[{"name":"Centre for Rural and Remote Mental Health, University of Newcastle, 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