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A case is reported of a woman, aged 61 years, with schizophrenia who refused her medication for four months, had the delusion she was dying from a tumour, and withdrew to her bed with a neglect of her nutrition. She was committed to hospital in a mute unresponsive state and after taking some food and fluids for four days lapsed into coma. She responded within three hours to the administration of thiamine. Clinicians need to remain vigilant to the possibility that an altered mental state in malnourished patients may be due to thiamine deficiency rather than to the primary psychiatric disorder. If doubt exists as to the presence of Wernicke's encephalopathy, then parenteral thiamine should be administered.<\/jats:p>","DOI":"10.3109\/00048679309075827","type":"journal-article","created":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T20:53:41Z","timestamp":1195678421000},"page":"638-652","source":"Crossref","is-referenced-by-count":9,"title":["Wernicke's Encephalopathy Complicating Schizophrenia"],"prefix":"10.1177","volume":"27","author":[{"given":"Bruce","family":"Spittle","sequence":"first","affiliation":[{"name":"Department of Psychological Medicine and Neuroscience Centre, University of Otago Medical School, PO Box 913, Dunedin, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josie","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Otago Medical School, Dunedin, New 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