{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:40:40Z","timestamp":1777412440344,"version":"3.51.4"},"reference-count":3,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:p>Objective: This report identifies neuroleptic malignant syndrome (NMS) occurring on a steady state dosage of clozapine monotherapy. Clinical picture: An outpatient presented with a recent history of stiffness and soreness of his legs, dizziness, polydipsia, polyuria, abdominal and chest pains. After admission to a general hospital, further symptomatology was identified including: pallor, diaphoresis, nausea, confusion, agitation, decrease in normal reflexes, minimally reactive pupils and rigid limbs. Treatment: Intravenous (I\/V) diazepam was administered but failed to decrease the agitation and confusion. He was sedated with the administered of IN drop-eradol, intubated and placed on a ventilator with circulatory supports for 4 days.<\/jats:p>\n                  <jats:p>Outcome: On day five he was extubated and transfered to a medical ward. All laboratory values had returned to normal values by this time. The patient was subsequently discharged.<\/jats:p>\n                  <jats:p>Conclusions: Neuroleptic malignant syndrome can occur at any stage of clozapine treatment, and the patient can be rechallenged after such an episode. This person was rechallenged and after 6 months of treatment has suffered no further recurrence of NMS.<\/jats:p>","DOI":"10.3109\/00048679609062668","type":"journal-article","created":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T20:55:57Z","timestamp":1195678557000},"page":"692-693","source":"Crossref","is-referenced-by-count":23,"title":["Neuroleptic Malignant Syndrome and Clozapine Monotherapy"],"prefix":"10.1177","volume":"30","author":[{"given":"Ray","family":"Chatterton","sequence":"first","affiliation":[{"name":"Clozaril Patient Monitoring System Wolston Park Hospital, Wacol, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susette","family":"Cardy","sequence":"additional","affiliation":[{"name":"Wolston Park Hospital, Wacol, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Mark","family":"Schramm","sequence":"additional","affiliation":[{"name":"Wolston Park Hospital, Wacol, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,10,1]]},"reference":[{"key":"bibr1-00048679609062668","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1993.tb04317.x"},{"key":"bibr2-00048679609062668","doi-asserted-by":"publisher","DOI":"10.3109\/10401239309148920"},{"key":"bibr3-00048679609062668","first-page":"70","volume":"54","author":"Weller M","year":"1993","journal-title":"Journal of Clinical Psychiatry"}],"container-title":["Australian &amp; New Zealand Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3109\/00048679609062668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3109\/00048679609062668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:50:51Z","timestamp":1777373451000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3109\/00048679609062668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10]]},"references-count":3,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,10]]}},"alternative-id":["10.3109\/00048679609062668"],"URL":"https:\/\/doi.org\/10.3109\/00048679609062668","relation":{},"ISSN":["0004-8674","1440-1614"],"issn-type":[{"value":"0004-8674","type":"print"},{"value":"1440-1614","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,10]]}}}