{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:43:53Z","timestamp":1777412633999,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>Objective: While clozapine-associated agranulocytosis has received extensive attention, a number of recent publications have identified that the incidence of eosinophilia may also be of concern. This retrospective review identifies the incidence of eosinophilia within a group of people commencing clozapine at a large hospital in Australia.<\/jats:p>\n                  <jats:p>\n                    Method: The pathology reports of all people (n = 160) who commenced clozapine within a 3.5\u2013year period were retrospectively reviewed for incidences of eosinophilia. Results: The incidence of eosinophilia was identified as 13%, comprising 17 males and four females. All cases of eosinophilia developed within 4 weeks of commencing clozapine. One male reached a peak eosinophil level of 9 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L, which resolved after clozapine was withdrawn. In all other cases, the eosinophilia resolved without intervention.\n                  <\/jats:p>\n                  <jats:p>Conclusions: With a rate of eosinophilia at 13% in this population under review, and given that there have been reports of 25 cases of eosinophilic cardiomyopothy resulting in four deaths worldwide, clinicians should be alert to the incidence and sequelae of eosinophilia in people receiving clozapine treatment.<\/jats:p>","DOI":"10.3109\/00048679709065515","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T11:24:07Z","timestamp":1201173847000},"page":"874-876","source":"Crossref","is-referenced-by-count":35,"title":["Eosinophilia after Commencement of Clozapine Treatment"],"prefix":"10.1177","volume":"31","author":[{"given":"Ray","family":"Chatterton","sequence":"first","affiliation":[{"name":"Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Wacol, Queensland, 4076, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,12,1]]},"reference":[{"key":"bibr1-00048679709065515","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800330013001"},{"key":"bibr2-00048679709065515","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307153290303"},{"key":"bibr3-00048679709065515","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90526-9"},{"key":"bibr4-00048679709065515","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.149.5.714a"},{"key":"bibr5-00048679709065515","doi-asserted-by":"publisher","DOI":"10.3109\/10401239509149034"},{"key":"bibr6-00048679709065515","first-page":"466","volume":"54","author":"Banov MD","year":"1993","journal-title":"Journal of Clinical Psychiatry"},{"key":"bibr7-00048679709065515","unstructured":"Lader M. Experience with clozapine in the United Kingdom. Presented at the NIMH New Clinical Drug Evaluation Unit Program, 31st Annual Meeting. Key Biscayne, Florida, 28\u201331 May 1991."},{"key":"bibr8-00048679709065515","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91090-U"},{"key":"bibr9-00048679709065515","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104183241607"},{"key":"bibr10-00048679709065515","first-page":"140","volume":"57","author":"Galletly C","year":"1995","journal-title":"Journal of Clinical Psychiatry"},{"key":"bibr11-00048679709065515","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(95)95439-G"},{"key":"bibr12-00048679709065515","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-1-78"},{"key":"bibr13-00048679709065515","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245622"}],"container-title":["Australian &amp; New Zealand Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3109\/00048679709065515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3109\/00048679709065515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:51:20Z","timestamp":1777373480000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3109\/00048679709065515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["10.3109\/00048679709065515"],"URL":"https:\/\/doi.org\/10.3109\/00048679709065515","relation":{},"ISSN":["0004-8674","1440-1614"],"issn-type":[{"value":"0004-8674","type":"print"},{"value":"1440-1614","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]}}}