{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:59:59Z","timestamp":1783749599168,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:p>Objective: The aim of this paper is to explore the longitudinal relationships between physical and psychological symptoms and immunological factors following acute infective illnesses.<\/jats:p>\n                  <jats:p>Method: Preliminary data from a prospective investigation of patients with serologically proven acute infectious illnesses due to Epstein-Barr virus (EBV), Ross River virus (RRV) or Q fever are reported. Patients were assessed within 4 weeks of onset of symptoms and then reviewed 2 and 4 weeks later. Physical illness data were collected at interview. Psychological and somatic symptom profiles were assessed by standardised self-report questionnaires. Cell-mediated immune (CMI) function was assessed by measurement of delayed-type hypersensitivity (DTH) skin responses.<\/jats:p>\n                  <jats:p>Results: Thirty patients who had been assessed and followed over the 4\u2013week period (including 17 patients with EBV, five with RRV and eight with Q fever) were included in this analysis. During the acute phase, profound fatigue and malaise were the most common symptoms. Classical depressive and anxiety symptoms were not prominent. Initially, 46% of cases had no DTH skin response (i.e. cutaneous anergy) indicative of impaired cellular immunity. Over the 4\u2013week period, there was a marked improvement in both somatic and psychological symptoms, although fatigue remained a prominent feature in 63% of subjects. The reduction in reported fatigue was correlated with improvement in the DTH skin response (p = 0.001) and with improvement in General Health Questionnaire (GHQ) scores (p &lt; 0.01).<\/jats:p>\n                  <jats:p>Conclusions: Acute infectious illnesses are accompanied by a range of nonspecific somatic and psychological symptoms, particularly fatigue and malaise rather than anxiety and depression. Although improvement in several symptoms occurs rapidly, fatigue commonly remains a prominent complaint at 4 weeks. Resolution of fatigue is associated with improvement in cell-mediated immunity.<\/jats:p>","DOI":"10.3109\/00048679809062727","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T11:24:33Z","timestamp":1201173873000},"page":"180-186","source":"Crossref","is-referenced-by-count":34,"title":["The Relationship between Fatigue, Psychological and Immunological Variables in Acute Infectious Illness"],"prefix":"10.1177","volume":"32","author":[{"given":"Barbara K.","family":"Bennett","sequence":"first","affiliation":[{"name":"School of Psychiatry, University of New South Wales, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian B.","family":"Hickie","sequence":"additional","affiliation":[{"name":"School of Psychiatry, University of New South Wales, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn","family":"Quigley","sequence":"additional","affiliation":[{"name":"School of 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