{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:30:19Z","timestamp":1782603019901,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology"],"published-print":{"date-parts":[[1993]]},"DOI":"10.3109\/00313029309068910","type":"journal-article","created":{"date-parts":[[2007,11,25]],"date-time":"2007-11-25T04:32:20Z","timestamp":1195965140000},"page":"90-94","source":"Crossref","is-referenced-by-count":23,"title":["Composite glandular-endocrine cell carcinoma of the extrahepatic bile duct: Immunohistochemical study"],"prefix":"10.1016","volume":"25","author":[{"given":"Kazuyoshi","family":"Nishihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masazumi","family":"Tsuneyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Niiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ichimiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3109\/00313029309068910_bib0005","first-page":"1588","article-title":"Uber ein Karzinoid des Ductus Choledochus","volume":"86","author":"Pilz","year":"1961","journal-title":"Zbl Chir"},{"key":"10.3109\/00313029309068910_bib0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/bjs.1800550221","article-title":"Primary common bile-duct carcinoid","volume":"55","author":"Little","year":"1968","journal-title":"Br J Surg"},{"key":"10.3109\/00313029309068910_bib0015","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/1097-0142(197508)36:2<560::AID-CNCR2820360235>3.0.CO;2-4","article-title":"Carcinoid tumors, an analysis of 2837 cases","volume":"36","author":"Godwin","year":"1975","journal-title":"Cancer"},{"key":"10.3109\/00313029309068910_bib0020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/ajcp\/66.1.40","article-title":"Nonfunctioning argyrophilic tumor (apudoma) of the hepatic duct","volume":"66","author":"Judge","year":"1976","journal-title":"Am J Clin Pathol"},{"key":"10.3109\/00313029309068910_bib0025","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1445-2197.1976.tb03217.x","article-title":"Carcinoid tumors of the biliary tract","volume":"46","author":"Bergdahl","year":"1976","journal-title":"Aust NZ J Surg"},{"key":"10.3109\/00313029309068910_bib0030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF01887536","article-title":"Primary common bile duct carcinoid","volume":"4","author":"Gerlock","year":"1979","journal-title":"Gastrointest Radiol"},{"key":"10.3109\/00313029309068910_bib0035","first-page":"360","article-title":"Carcinoid tumor of the common bile duct","volume":"76","author":"Vitaux","year":"1981","journal-title":"Am J Gastroenterol"},{"key":"10.3109\/00313029309068910_bib0040","first-page":"543","article-title":"Carcinoid tumor of the common bile duct","volume":"18","author":"Abe","year":"1983","journal-title":"report of a case. I to Cho (Stomach and Intestine)"},{"key":"10.3109\/00313029309068910_bib0045","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/BF01296145","article-title":"Carcinoid tumor of the biliary system: Case report and literature review","volume":"32","author":"Jutte","year":"1986","journal-title":"Dig Dis Sci"},{"key":"10.3109\/00313029309068910_bib0050","first-page":"48","article-title":"Carcinoid tumor of the biliary tree: A case report and review of the literature","volume":"32","author":"Bickerstaff","year":"1987","journal-title":"JR Coll Surg Edin"},{"key":"10.3109\/00313029309068910_bib0055","first-page":"191","article-title":"Primares Karzinoid des Ductus Choledochus","volume":"29","author":"Wrazidlo","year":"1989","journal-title":"Radiologe"},{"key":"10.3109\/00313029309068910_bib0060","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/ajcp\/96.3.341","article-title":"Primary carcinoid of the common bile duct. Immunohistochemical characterization of a case and review of the literature","volume":"96","author":"Angeles-Angeles","year":"1991","journal-title":"Am J Clin Pathol"},{"key":"10.3109\/00313029309068910_bib0065","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/jso.2930450306","article-title":"Small cell carcinoma of the pancreas and biliary tract","volume":"45","author":"Motojima","year":"1990","journal-title":"J Surg Oncol"},{"key":"10.3109\/00313029309068910_bib0070","first-page":"370","article-title":"Argyrophil and argentaffin cells in carcinomas of the colon and rectum","volume":"70","author":"lwashita","year":"1979","journal-title":"Fukuoka Acta Medicine"},{"key":"10.3109\/00313029309068910_bib0075","first-page":"1029","article-title":"Argyrophil and argentaffin cells in carcinomas of the small intestine","volume":"16","author":"lwashita","year":"1981","journal-title":"I to Cho (Stomach and Intestine)"},{"key":"10.3109\/00313029309068910_bib0080","series-title":"Cancer","article-title":"Mammay carcinoma with argyrophil cells","author":"Toyoshima","year":"1983"},{"key":"10.3109\/00313029309068910_bib0085","first-page":"287","article-title":"Neuroendocrine cells and neuroendocrine neoplasms of the lung","volume":"18","author":"Could","year":"1983","journal-title":"Pathol Annu"},{"key":"10.3109\/00313029309068910_bib0090","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00390467","article-title":"Endocrine cells in extrahepatic bile duct carcinoma","volume":"108","author":"Yamamoto","year":"1984","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.3109\/00313029309068910_bib0095","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1365-2559.1986.tb02460.x","article-title":"The prevalence, prognostic significance and hormonal content of endocrine cells in gastric cancer","volume":"10","author":"Bonar","year":"1986","journal-title":"Histopathology"},{"key":"10.3109\/00313029309068910_bib0100","first-page":"1853","article-title":"Mucin-producing carcinoid (\u201ccomposite tumor\u201d) of upper third of esophagus","volume":"44","author":"Chong","year":"1979","journal-title":"A variant of carcinoid tumor. Cancer"},{"key":"10.3109\/00313029309068910_bib0105","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/00000478-199106000-00008","article-title":"Mixed (composite) glandular-endocrine cell carcinoma of the stomach. Report of a case and review of the literature","volume":"15","author":"Yang","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"10.3109\/00313029309068910_bib0110","first-page":"633","article-title":"Composite tumor of the gallbladder exhibiting both carcinomatous and carcinoidal patterns","volume":"58","author":"Wisniewski","year":"1972","journal-title":"Am J Gastroenterol"},{"key":"10.3109\/00313029309068910_bib0115","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1002\/1097-0142(19830515)51:10<1911::AID-CNCR2820511026>3.0.CO;2-L","article-title":"Carcinoid tumor of the gall-bladder associated with adenocarcinoma","volume":"51","author":"Wada","year":"1983","journal-title":"Cancer"},{"key":"10.3109\/00313029309068910_bib0120","first-page":"1313","article-title":"Carcinoid with coexisting adenocarcinoma of the gallbladder: report of a case","volume":"39","author":"Kotake","year":"1984","journal-title":"J Clin Surg"},{"key":"10.3109\/00313029309068910_bib0125","first-page":"645","article-title":"Composite tumor (ordinary adenocarcinoma, typical carcinoid, and goblet cell adenocarcinoid) of the gallbladder: a variety of composite tumor","volume":"79","author":"Muto","year":"1984","journal-title":"Am J Gastroenterol"},{"key":"10.3109\/00313029309068910_bib0130","first-page":"1308","article-title":"Association of adenocarcinoma and endocrine cell carcinoma in the gallbladder \u2014 A case report","volume":"85","author":"Adachi","year":"1988","journal-title":"Nippon Shokakibyo Gakkai Zasshi"},{"key":"10.3109\/00313029309068910_bib0135","first-page":"953","article-title":"Carcinoid tumors of the gallbladder with adenocarcinomatous differentiation: a morphologic and immunohistochemical study","volume":"84","author":"Noda","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"10.3109\/00313029309068910_bib0140","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/00000478-198904000-00004","article-title":"Endocrine cell carcinoma (carcinoid) of the gallbladder","volume":"13","author":"Yamamoto","year":"1989","journal-title":"Am J Surg Pathol"},{"key":"10.3109\/00313029309068910_bib0145","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2559.1990.tb00772.x","article-title":"Combined endocrine cell carcinoma and adenocarcinoma of the gallbladder","volume":"17","author":"Fish","year":"1990","journal-title":"Histopathology"},{"key":"10.3109\/00313029309068910_bib0150","first-page":"472","article-title":"Small-cell carcinoma of the gallbladder","volume":"187","author":"Cavazzana","year":"1991","journal-title":"An immunocytochemical and ultrastructural study. Pathol Res Pract"},{"key":"10.3109\/00313029309068910_bib0155","first-page":"841","article-title":"Small cell carcinoma of the gallbladder combined with adenocarcinoma","volume":"41","author":"Duan","year":"1991","journal-title":"Acta Pathol Jpn"},{"key":"10.3109\/00313029309068910_bib0160","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0046-8177(89)90187-1","article-title":"Adenocarcinoid tumor of the periampullary region: A novel duodenal neoplasm presenting as biliary tract obstruction","volume":"20","author":"Jones","year":"1989","journal-title":"Hum Pathol"},{"key":"10.3109\/00313029309068910_bib0165","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/BF02616821","article-title":"Composite carcinoid tumor (Argentaffinoma-adenocarcinoma) of the colon: report of two cases","volume":"10","author":"Bates","year":"1967","journal-title":"Dis Colon Rectum"},{"key":"10.3109\/00313029309068910_bib0170","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00000478-197712000-00001","article-title":"Primary carcinoid tumor of the breast. A report of eight patients","volume":"1","author":"Cubilla","year":"1977","journal-title":"Am J Surg Pathol"},{"key":"10.3109\/00313029309068910_bib0175","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/1097-0142(197907)44:1<307::AID-CNCR2820440152>3.0.CO;2-F","article-title":"Carcinoid tumor of the prostate associated with adenocarcinoma","volume":"44","author":"Montasser","year":"1979","journal-title":"Cancer"},{"key":"10.3109\/00313029309068910_bib0180","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/1097-0142(19810215)47:4<785::AID-CNCR2820470425>3.0.CO;2-Z","article-title":"Cervical carcinoid (\u201cargyrophil cell\u1fa0carcinoma) associated with an endocervical adenocarcinoma: A light and ultrastructural study","volume":"47","author":"Mullins","year":"1981","journal-title":"Cancer"},{"key":"10.3109\/00313029309068910_bib0185","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures","volume":"29","author":"Hsu","year":"1981","journal-title":"J Histochem Cytochem"},{"issue":"suppl 1","key":"10.3109\/00313029309068910_bib0190","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00000478-198700111-00007","article-title":"Carcinoid tumors and the mixed (composite) glandular-endocrine cell carcinomas","volume":"11","author":"Lewin","year":"1987","journal-title":"Am J Surg Pathol"},{"key":"10.3109\/00313029309068910_bib0195","first-page":"7","article-title":"Hyperplasias and tumors of the disseminated endocrine (paracrine) Hellen Zellen Feyrter's of the gut with special regard to amphicrine cell proliferations","volume":"61","author":"Ratzenhofer","year":"1977"},{"key":"10.3109\/00313029309068910_bib0200","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1002\/1097-0142(19851201)56:11<2683::AID-CNCR2820561127>3.0.CO;2-L","article-title":"Amphicrine cells, dysplasia, and neoplasias","volume":"56","author":"Chejfec","year":"1985","journal-title":"Cancer"},{"key":"10.3109\/00313029309068910_bib0205","first-page":"369","article-title":"Composite tumor exhibiting both carcinoid and undifferentiated carcinoma of the gallbladder","volume":"69","author":"Ito","year":"1980","journal-title":"Tr SOC Pathol Jpn"},{"key":"10.3109\/00313029309068910_bib0210","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2559.1990.tb00716.x","article-title":"Signet-ring cell carcinoid of the gallbladder","volume":"17","author":"Papotti","year":"1990","journal-title":"Histopathology"},{"key":"10.3109\/00313029309068910_bib0215","first-page":"19","article-title":"Intestinal-type adeno-carcinoma of the gallbladder. A clinicopathologic and immunocytochemical study of seven cases","volume":"10","author":"Albores-Saavedra","year":"1986","journal-title":"Am J Surg Pathol"},{"key":"10.3109\/00313029309068910_bib0220","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0046-8177(84)80288-9","article-title":"Oat cell carcinoma of the gallbladder","volume":"15","author":"Albores-Saavedra","year":"1984","journal-title":"Hum Pathol"},{"key":"10.3109\/00313029309068910_bib0225","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0140-6736(81)92682-9","article-title":"Neuron-specific enolase is produced by neuroendocrine tumors","volume":"2","author":"Tapia","year":"1981","journal-title":"Lancet"},{"key":"10.3109\/00313029309068910_bib0230","first-page":"458","article-title":"Detection of chromogranin in neuroendocrine cells with a monoclonal antibody","volume":"115","author":"Wilson","year":"1984","journal-title":"Am J Pathol"},{"key":"10.3109\/00313029309068910_bib0235","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/jcp.37.9.975","article-title":"Monoclonal antibody to cytokeratin for use in routine histopathology","volume":"37","author":"Makin","year":"1984","journal-title":"J Clin Pathol"},{"key":"10.3109\/00313029309068910_bib0240","series-title":"Virchow Arch","first-page":"271","article-title":"Immunohistochemistry of carcinoembryonic antigen, secretory component and lysozome in benign and malignant common bile duct tissues","author":"Nagura","year":"1984"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516356987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516356987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T22:00:25Z","timestamp":1546466425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302516356987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993]]}},"alternative-id":["S0031302516356987"],"URL":"https:\/\/doi.org\/10.3109\/00313029309068910","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[1993]]}}}