{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:20:12Z","timestamp":1784384412455,"version":"3.55.0"},"reference-count":83,"publisher":"Informa UK Limited","issue":"5","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Journal of Gastroenterology"],"published-print":{"date-parts":[[2015,5,4]]},"DOI":"10.3109\/00365521.2015.1009941","type":"journal-article","created":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T07:21:22Z","timestamp":1423552882000},"page":"550-559","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":39,"title":["Gastric neuroendocrine tumors: prevalence in Europe, USA, and Japan, and rationale for treatment with a gastrin\/CCK<sub>2<\/sub>receptor antagonist"],"prefix":"10.3109","volume":"50","author":[{"given":"Malcolm","family":"Boyce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liv","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"CIT0001","first-page":"13","volume-title":"WHO Classification of Tumors of the Digestive System","author":"Rindi G","year":"2010","edition":"4"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0013"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0031-6997(24)01427-3","volume":"51","author":"Noble F","year":"1999","journal-title":"Pharmacol Rev"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.119"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1113\/expphysiol.2006.036483","volume":"92","author":"Dimaline R","year":"2007","journal-title":"Exp Physiol"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1258\/000456303322326380","volume":"40","author":"Varro A","year":"2003","journal-title":"Ann Clin Biochem"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"G446","DOI":"10.1152\/ajpgi.00527.2010","volume":"301","author":"N\u00f8rsett KG","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90283.2008"},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"G1133","DOI":"10.1152\/ajpgi.00526.2006","volume":"292","author":"Varro A","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90340.2008"},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0016-5085(03)00908-9","volume":"125","author":"Khan ZE","year":"2003","journal-title":"Gastroenterology"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"G1726","DOI":"10.1152\/ajpgi.00348.2006","volume":"292","author":"Tu S","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/nrc2014","volume":"6","author":"Watson SA","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/labinvest.3700462","volume":"86","author":"Cui G","year":"2006","journal-title":"Lab Invest"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/0016-5085(93)90266-F","volume":"104","author":"Rindi G","year":"1993","journal-title":"Gastroenterology"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/j.1365-2036.2006.03130.x","volume":"24","author":"Burkitt MD","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrgastro.2013.101","volume":"10","author":"Neumann WL","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-011-0225-5"},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3748\/wjg.v18.i12.1279","volume":"18","author":"Vannella L","year":"2012","journal-title":"World J Gastroenterol"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.06.001"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/hel.12066","volume":"18","author":"S\u00f8rdal \u00d8","year":"2013","journal-title":"Helicobacter"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/MOG.0b013e328365efb1","volume":"29","author":"Ito T","year":"2013","journal-title":"Curr Opin Gastroenterol"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1210\/jc.2007-2279","volume":"93","author":"Berna M","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.3748\/wjg.14.1646","volume":"14","author":"Fossmark R","year":"2008","journal-title":"World J Gastroenterol"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1999.tb01513.x"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/0016-5085(92)90787-Y","volume":"102","author":"Hirschowitz BI","year":"1992","journal-title":"Gastroenterology"},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/med.10042","volume":"23","author":"Herranz R","year":"2003","journal-title":"Med Res Rev"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2002.910602.x"},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1021\/jm960669+","volume":"40","author":"Semple G","year":"1997","journal-title":"J Med Chem"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1365-2036.1997.110281000.x","volume":"11","author":"Takinami Y","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"key":"CIT0031","first-page":"403","volume":"48","author":"Takemoto Y","year":"1998","journal-title":"Arzneimittelforschung"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/sj.bjp.0704037","volume":"133","author":"Konagaya T","year":"2001","journal-title":"Br J Pharmacol"},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s004410050008","volume":"299","author":"Chen D","year":"2000","journal-title":"Cell Tissue Res"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgg156"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.regpep.2010.01.009","volume":"162","author":"Kidd M","year":"2010","journal-title":"Regul Pept"},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2036.2012.05143.x","volume":"36","author":"Boyce M","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/bcp.12095","volume":"76","author":"Boyce M","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"CIT0038","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/bcp.12099","volume":"76","author":"Boyce M","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12534"},{"key":"CIT0040","unstructured":"Recommendation on elements required to support the medical plausibility and the assumption of significant benefit for an orphan designation EMA\/COMP\/15893\/2009. In COMP, editor. London, UK: European Medicines Agency; 2010."},{"key":"CIT0041","unstructured":"European Commission Enterprise Directorate-General. Guideline on the Format and Content of Applications for Designation as Orphan Medicinal Products and on the Transfer of Designations from One Sponsor to Another (ENTR\/6283\/00 Rev 3), Brussels: European Commission; 2007."},{"key":"CIT0046","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1572-0241.2003.04027.x","volume":"99","author":"Modlin IM","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00535-007-2056-6","volume":"42","author":"Ito T","year":"2007","journal-title":"J Gastroenterol"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s00535-009-0194-8","volume":"45","author":"Ito T","year":"2010","journal-title":"J Gastroenterol"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23883"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-10-0152"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-005-0232-4"},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1200\/JCO.2007.15.4377","volume":"26","author":"Yao JC","year":"2008","journal-title":"J Clin Oncol"},{"key":"CIT0056","first-page":"80","volume":"3","author":"Scott E","year":"1960","journal-title":"J Coll Gen Pract"},{"key":"CIT0057","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.0954-6820.1969.tb07363.x","volume":"185","author":"Pedersen AB","year":"1969","journal-title":"Acta Med Scand"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00040041097008"},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/00365528609034616","volume":"21","author":"Borch K","year":"1986","journal-title":"Scand J Gastroenterol"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850166266"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.1.28"},{"key":"CIT0062","first-page":"103","volume":"17","author":"Potet F","year":"1993","journal-title":"Gastroenterol Clin Biol"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5121"},{"key":"CIT0064","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/cncr.20939","volume":"103","author":"Soga J","year":"2005","journal-title":"Cancer"},{"key":"CIT0065","first-page":"87","volume":"42","author":"Soga J","year":"1994","journal-title":"Acta Med Biol"},{"key":"CIT0066","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1007\/BF02388135","volume":"27","author":"Soga J","year":"1997","journal-title":"Surg Today"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.341"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04659.x"},{"key":"CIT0071","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.3748\/wjg.15.2177","volume":"15","author":"Massironi S","year":"2009","journal-title":"World J Gastroenterol"},{"key":"CIT0072","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0016-5085(90)90946-X","volume":"99","author":"Jansen JB","year":"1990","journal-title":"Gastroenterology"},{"key":"CIT0073","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00042737-200505000-00013","volume":"17","author":"Rindi G","year":"2005","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05106.x"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00768.x"},{"key":"CIT0076","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1742-7843.2006.pto_378.x","volume":"98","author":"Jensen RT","year":"2006","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.1.1.29"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.627444"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12012"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12177"},{"key":"CIT0081","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/PL00009955","volume":"5","author":"Soga J","year":"1998","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"CIT0082","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0960-7404(03)00034-3","volume":"12","author":"Modlin I","year":"2001","journal-title":"Surg Oncol"},{"key":"CIT0083","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1023\/A:1017972204219","volume":"47","author":"Sato Y","year":"2002","journal-title":"Dig Dis Sci"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1159\/000085237"},{"key":"CIT0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000335600","volume":"95","author":"Salazar R","year":"2012","journal-title":"Neuroendocrinology"},{"key":"CIT0086","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/MPA.0b013e3181ebb168","volume":"39","author":"Kulke MH","year":"2010","journal-title":"Pancreas"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1159\/000329043"},{"key":"CIT0088","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2036.2009.04174.x","volume":"31","author":"Modlin IM","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"CIT0089","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/jso.20468","volume":"93","author":"Dakin GF","year":"2006","journal-title":"J Surg Oncol"},{"key":"CIT0090","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jss.2010.01.005","volume":"162","author":"Ozao-Choy J","year":"2010","journal-title":"J Surg Res"},{"key":"CIT0091","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/apt.12090","volume":"36","author":"Fossmark R","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"CIT0092","doi-asserted-by":"crossref","first-page":"e76462","DOI":"10.1371\/journal.pone.0076462","volume":"8","author":"Moore AR","year":"2013","journal-title":"PLoS One"}],"container-title":["Scandinavian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/00365521.2015.1009941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T19:28:30Z","timestamp":1747596510000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.3109\/00365521.2015.1009941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,9]]},"references-count":83,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,2,24]]},"published-print":{"date-parts":[[2015,5,4]]}},"alternative-id":["10.3109\/00365521.2015.1009941"],"URL":"https:\/\/doi.org\/10.3109\/00365521.2015.1009941","relation":{},"ISSN":["0036-5521","1502-7708"],"issn-type":[{"value":"0036-5521","type":"print"},{"value":"1502-7708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=igas20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=igas20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}