{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:19:24Z","timestamp":1777472364681,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:p>\n                    Purpose: Normal radioactivity in the liver is often shown to be higher in the left lobe than in the right lobe at clinical examination by single photon emission computed tomography (SPECT) with\n                    <jats:sup>123<\/jats:sup>\n                    I-metaiodobenzylguanidine (\n                    <jats:sup>123<\/jats:sup>\n                    I-MIBG). Our objective was to determine whether this represents a pathological condition.\n                  <\/jats:p>\n                  <jats:p>\n                    Material and Methods: The distribution of\n                    <jats:sup>123<\/jats:sup>\n                    I-MIBG in the liver was retrospectively studied in clinical patients who had normal CT examinations of the liver and spleen. In the SPECT sections of 27\n                    <jats:sup>123<\/jats:sup>\n                    I-MIBG examinations, we determined the activity ratios between the left and right lobes. The control group comprised 33 examinations with\n                    <jats:sup>111<\/jats:sup>\n                    In-pentetreotide (OctreoScan) and 23 examinations with\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-antigranulocyte antibody.\n                  <\/jats:p>\n                  <jats:p>\n                    Results: The mean activity ratio between left and right lobes for\n                    <jats:sup>123<\/jats:sup>\n                    I-MIBG was 1.24, and for\n                    <jats:sup>111<\/jats:sup>\n                    In-pentetreotide 0.87. These figures differed significantly both from each other and from 1.00. The mean ratio for\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-antibody at the early examinations was 0.99, and at the late examinations 0.95. These figures differed significantly from the values for\n                    <jats:sup>123<\/jats:sup>\n                    I-MIBG and\n                    <jats:sup>111<\/jats:sup>\n                    In-pentetreotide.\n                  <\/jats:p>\n                  <jats:p>\n                    Conclusion: The increased concentration of\n                    <jats:sup>123<\/jats:sup>\n                    I-MIBG in the left lobe of the liver compared to the right lobe is a normal finding. The reason for this cannot be explained. The difference in the way in which the left and right lobes deal with the three radiopharmaceuticals is a new finding and indicates a regional difference in liver function that has not been reported previously.\n                  <\/jats:p>","DOI":"10.3109\/02841859909177744","type":"journal-article","created":{"date-parts":[[2009,10,6]],"date-time":"2009-10-06T19:01:03Z","timestamp":1254855663000},"page":"224-228","source":"Crossref","is-referenced-by-count":12,"title":["Concentration of\n                    <sup>123<\/sup>\n                    I-Metaiodobenzyl-Guanidine in Left and Right Liver Lobes"],"prefix":"10.1177","volume":"40","author":[{"given":"H.","family":"Jacobsson","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kimiaei","sequence":"additional","affiliation":[{"name":"Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,3,1]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3109\/02841859909177744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3109\/02841859909177744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:44:14Z","timestamp":1777383854000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3109\/02841859909177744"}},"subtitle":["Findings indicate regional differences in function in the normal liver"],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["10.3109\/02841859909177744"],"URL":"https:\/\/doi.org\/10.3109\/02841859909177744","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}