{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:26:47Z","timestamp":1793395607552,"version":"4.5.0"},"reference-count":333,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism Reviews"],"published-print":{"date-parts":[[2016,1,2]]},"DOI":"10.3109\/03602532.2016.1151037","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T08:03:27Z","timestamp":1456387407000},"page":"88-112","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":160,"title":["Clinical determinants of calcineurin inhibitor disposition: a mechanistic review"],"prefix":"10.3109","volume":"48","author":[{"given":"Thomas","family":"Vanhove","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Annaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk R. J.","family":"Kuypers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/030006059101900101","volume":"19","author":"Akagi H","year":"1991","journal-title":"J Int Med Res"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1997.t01-1-00625.x"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241090-00001"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1177\/011542650702200116"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/953520"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168750"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.043018"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1592\/phco.29.6.680"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.430"},{"key":"CIT0010","unstructured":"Anonymous. International HapMap Project. Available from: http:\/\/hapmap.ncbi.nlm.nih.gov [last accessed 15 June 2015]."},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01224-8"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12194"},{"key":"CIT0013","unstructured":"Astellas Pharma US. (2013). Tacrolimus (Prograf\u00ae): Prescribing information. Available from: https:\/\/www.astellas.us\/docs\/prograf.pdf [last accessed 1 Nov 2015]."},{"key":"CIT0014","first-page":"1193","volume":"22","author":"Awni WM","year":"1990","journal-title":"Transplant Proc"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100104"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2008.01.003"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01759.x"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122010519"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122010104"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122009999"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1021\/mp0600687"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/FTD.0b013e31829f1ab8","volume":"36","author":"Bergmann TK","year":"2014","journal-title":"Ther Drug Monitor"},{"key":"CIT0023","first-page":"2745","volume":"23","author":"Beysens AJ","year":"1991","journal-title":"Transplant Proc"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.034728"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.2.373"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20088"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(02)03013-0"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199003000-00041"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/S0944-7113(00)80044-6"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181d2fed7"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-827223"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199630020-00004"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199105000-00016"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/j.1440-1681.2007.04691.x","volume":"34","author":"Canaparo R","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.10.43"},{"key":"CIT0036","first-page":"1","volume":"29","author":"Chen D","year":"2013","journal-title":"Drug Metab Pharmacokinet"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.08.014"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X06004338"},{"key":"CIT0039","first-page":"610","volume":"25","author":"Chow FS","year":"1997","journal-title":"Drug Metab Dispos"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00238-3"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241110-00003"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199011000-00003"},{"key":"CIT0043","first-page":"65","volume":"2010","author":"Coscia LA","year":"2010","journal-title":"Clin Transpl"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544010-00002"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3282f7046f"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01531005"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.09.015"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181e9feda"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.109"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.13.133"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.130"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12703"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.10594"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.121152"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9236(95)90032-2"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.112240"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-11-RG-105"},{"key":"CIT0058","unstructured":"EMA. (2007). Advagraf: EPAR. Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Scientific_Discussion\/human\/000712\/WC500022237.pdf [last accessed 1 Nov 2015]."},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20030"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.054932"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.042"},{"key":"CIT0062","unstructured":"European Medicines Agency. (2012). Guideline on the Investigation of Drug Interactions Guideline on the Investigation of Drug Interactions Table of contents. Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2012\/07\/WC500129606.pdf [last accessed 1 Nov 2015]."},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600780605"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200608000-00011"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31818aa4b6"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.2165\/11313380-000000000-00000"},{"key":"CIT0067","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1365-2125.2007.03003.x","volume":"64","author":"Fanta S","year":"2007","journal-title":"Br J Clin Pharmacol"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01238.x"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70210-1"},{"key":"CIT0070","unstructured":"FDA. (2012). Guidance for industry. Drug interaction studies study design, data analysis, implications for dosing, and labeling recommendations. Available from: http:\/\/www.fda.gov\/downloads\/drugs\/guidancecomplianceregulatoryinformation\/guidances\/ucm292362.pdf [last accessed 5 Nov 2015]."},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2002.01103.x"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00662.x"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199409270-00016"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1021\/ci400195v"},{"key":"CIT0075","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1399-0012.1996.tb00645.x","volume":"10","author":"First MR","year":"1996","journal-title":"Clin Transpl"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00275-9"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(97)90150-8"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.1.265"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1159\/000075545"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64794-3"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.005002088.x"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1007\/s002280100331"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.06.008"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1159\/000212676"},{"key":"CIT0085","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0022-3565(24)39087-1","volume":"294","author":"Ganapathy V","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01933.x"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200140010-00005"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24443"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010173200"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-012-0918-y"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01446.x"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1016\/S1382-6689(96)00075-0"},{"key":"CIT0093","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0090-9556(24)15274-9","volume":"27","author":"Gibbs MA","year":"1999","journal-title":"Drug Metab Dispos"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2004.02265.x"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr253"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.2165\/11587050-000000000-00000"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.10.008"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9236(95)90067-5"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00187-5"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.11.010"},{"key":"CIT0101","first-page":"9","volume":"18","author":"Grevel J.","year":"1986","journal-title":"Transplant Proc"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1007\/BF00606661"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.041350"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1989.tb05396.x"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.113697"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1177\/00912709922007499"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003261078"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.171"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-013-0120-3"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3282f75f88"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00168-1"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2001.tb00050.x"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9120(91)90336-D"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.07.061"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)02235-X"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25831"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(92)90106-N"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12470"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703224"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182461288"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04232.x"},{"key":"CIT0122","first-page":"2763","volume":"23","author":"Jain AB","year":"1991","journal-title":"Transplant Proc"},{"key":"CIT0123","first-page":"57","volume":"22","author":"Jain AB","year":"1990","journal-title":"Transplant Proc"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.34880"},{"key":"CIT0125","first-page":"375263","volume":"2013","author":"Jantz AS","year":"2013","journal-title":"Case Rep Transplant"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9236(95)90153-1"},{"key":"CIT0127","first-page":"115","volume":"18","author":"Kahan BD","year":"1986","journal-title":"Transplant Proc"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.32.1.20"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.5414\/CPP40485"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.114.057232"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.07.038"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100237"},{"key":"CIT0133","first-page":"79","volume":"30","author":"Kim C-S","year":"2010","journal-title":"Anticancer Res"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1182-5"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2001.150504.x"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1021\/mp500590s"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.10.1108"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92302-I"},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199410000-00003"},{"key":"CIT0140","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199915030-00003"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2010.01373.x"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01908.x"},{"key":"CIT0143","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200502000-00020"},{"key":"CIT0144","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.12.019"},{"key":"CIT0145","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328307c26e"},{"key":"CIT0146","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443110-00005"},{"key":"CIT0147","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.001503"},{"key":"CIT0148","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100216"},{"key":"CIT0149","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.11.010"},{"key":"CIT0150","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181e06818"},{"key":"CIT0151","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815489"},{"key":"CIT0152","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.019"},{"key":"CIT0153","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(01)02678-1"},{"key":"CIT0154","doi-asserted-by":"publisher","DOI":"10.1159\/000312690"},{"key":"CIT0155","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.026187"},{"key":"CIT0156","doi-asserted-by":"crossref","first-page":"e0122399","DOI":"10.1371\/journal.pone.0122399","volume":"10","author":"Lee JR","year":"2015","journal-title":"PLoS One"},{"key":"CIT0157","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.8.1069"},{"key":"CIT0158","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1987.tb03436.x"},{"key":"CIT0159","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00844.x"},{"key":"CIT0160","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00028.2003"},{"key":"CIT0161","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.03.095"},{"key":"CIT0162","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00539.x"},{"key":"CIT0163","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2007.00850.x"},{"key":"CIT0164","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.157"},{"key":"CIT0165","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2010.42"},{"key":"CIT0166","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0090-9556(24)15346-9","volume":"28","author":"Lian-Qing G","year":"2000","journal-title":"Drug Metab Dispos"},{"key":"CIT0167","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/ajhp\/57.17.1579","volume":"57","author":"Lill J","year":"2000","journal-title":"Am J Health Syst Pharm"},{"key":"CIT0168","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2011.1596"},{"key":"CIT0169","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.1.162"},{"key":"CIT0170","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1990.tb03677.x"},{"key":"CIT0171","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.156"},{"key":"CIT0172","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.42.4.370-a"},{"key":"CIT0173","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(97)00027-6"},{"key":"CIT0174","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0702-z"},{"key":"CIT0175","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3931"},{"key":"CIT0176","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119439"},{"key":"CIT0177","doi-asserted-by":"publisher","DOI":"10.1007\/BF00192360"},{"key":"CIT0178","doi-asserted-by":"publisher","DOI":"10.2165\/11318000-000000000-00000"},{"key":"CIT0179","doi-asserted-by":"publisher","DOI":"10.1046\/j.1397-3142.2000.00000.x"},{"key":"CIT0180","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.21018.x"},{"key":"CIT0181","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.07.004"},{"key":"CIT0182","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg002"},{"key":"CIT0183","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011971303880"},{"key":"CIT0184","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90848-P"},{"key":"CIT0185","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.113183"},{"key":"CIT0186","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199457120-00027"},{"key":"CIT0187","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00235-8"},{"key":"CIT0188","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000280"},{"key":"CIT0189","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.11.1500"},{"key":"CIT0190","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199802000-00019"},{"key":"CIT0191","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1399-0012.1996.tb00467.x","volume":"10","author":"Marterre WF","year":"1996","journal-title":"Clin Transplant"},{"key":"CIT0192","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/mol.58.3.624","volume":"58","author":"Martin C","year":"2000","journal-title":"Mol Pharmacol"},{"key":"CIT0193","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200104270-00011"},{"key":"CIT0194","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.110215"},{"key":"CIT0195","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199306000-00022"},{"key":"CIT0196","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1988.tb03348.x"},{"key":"CIT0197","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702053"},{"key":"CIT0198","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200003150-00037"},{"key":"CIT0199","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31811f319b"},{"key":"CIT0200","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0395-0"},{"key":"CIT0201","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0721-9"},{"key":"CIT0202","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0090-9556(24)15298-1","volume":"27","author":"M\u00f6ller A","year":"1999","journal-title":"Drug Metab Dispos"},{"key":"CIT0203","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012030260"},{"key":"CIT0204","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026183200740"},{"key":"CIT0205","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018922517162"},{"key":"CIT0206","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009020192"},{"key":"CIT0207","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1994.tb03752.x"},{"key":"CIT0208","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.3.391"},{"key":"CIT0209","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1471-2"},{"key":"CIT0210","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318277438f"},{"key":"CIT0211","doi-asserted-by":"publisher","DOI":"10.1177\/0091270011413588"},{"key":"CIT0212","first-page":"515","volume":"65","author":"Neylan JF.","year":"1998","journal-title":"FK506 Kidney Transplant Study Group. Transplantation"},{"key":"CIT0213","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31826bc400"},{"key":"CIT0214","first-page":"447","volume":"36","author":"Nishioka T","year":"1990","journal-title":"Hinyokika Kiyo"},{"key":"CIT0215","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.127.209"},{"key":"CIT0216","unstructured":"Novartis. (2015). Cyclosporine (Neoral\u00ae): Prescribing information, Available from: https:\/\/www.pharma.us.novartis.com\/product\/pi\/pdf\/neoral.pdf [last accessed 1 Nov 2015]."},{"key":"CIT0217","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/j.1875-9114.1998.tb03160.x","volume":"18","author":"Olyaei AJ","year":"1998","journal-title":"Pharmacotherapy"},{"key":"CIT0218","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21387"},{"key":"CIT0219","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2007.00504.x"},{"key":"CIT0220","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199604270-00026"},{"key":"CIT0221","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S0022-3565(24)37149-6","volume":"283","author":"Paine MF","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0222","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)90162-9"},{"key":"CIT0223","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/ajcn\/83.5.1097","volume":"83","author":"Paine MF","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"CIT0224","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/ajcn\/87.4.863","volume":"87","author":"Paine MF","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"CIT0225","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04039.x"},{"key":"CIT0226","doi-asserted-by":"publisher","DOI":"10.1002\/jps.1108"},{"key":"CIT0227","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-006-0357-8"},{"key":"CIT0228","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1177\/135965350801300516","volume":"13","author":"Pea F","year":"2008","journal-title":"Antivir Ther"},{"key":"CIT0229","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1681\/ASN.V76831","volume":"7","author":"Pesavento TE","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"CIT0230","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0090-9556(25)07474-4","volume":"21","author":"Piekoszewski W","year":"1993","journal-title":"Drug Metab Dispos"},{"key":"CIT0231","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.1998.tb01131.x"},{"key":"CIT0232","first-page":"107","volume":"96","author":"Prasad TNV","year":"1997","journal-title":"Res Commun Mol Pathol Pharmacol"},{"key":"CIT0233","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702588"},{"key":"CIT0234","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.053892"},{"key":"CIT0235","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2808"},{"key":"CIT0236","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00368.x"},{"key":"CIT0237","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0022-3565(24)29202-8","volume":"299","author":"Rae JM","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0238","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.020065"},{"key":"CIT0239","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1177\/106002808802200710","volume":"22","author":"Roberts R","year":"1988","journal-title":"Drug Intell Clin Pharm"},{"key":"CIT0240","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.105.003822"},{"key":"CIT0241","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1016\/S0021-9258(18)53221-X","volume":"268","author":"Saeki T","year":"1993","journal-title":"J Biol Chem"},{"key":"CIT0242","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.27.1480"},{"key":"CIT0243","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90601-7"},{"key":"CIT0244","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.6.825"},{"key":"CIT0245","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.002337"},{"key":"CIT0246","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118214"},{"key":"CIT0247","first-page":"1228","volume":"25","author":"Schmiedlin-Ren P","year":"1997","journal-title":"Drug Metab. Dispos"},{"key":"CIT0248","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00352.x"},{"key":"CIT0249","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2510252.x"},{"key":"CIT0250","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(00)00177-9"},{"key":"CIT0251","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199907270-00027"},{"key":"CIT0252","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2002.6359"},{"key":"CIT0253","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23653"},{"key":"CIT0254","doi-asserted-by":"publisher","DOI":"10.1177\/0897190010377804"},{"key":"CIT0255","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000114594.21317.A5"},{"key":"CIT0256","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2008.00980.x"},{"key":"CIT0257","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(00)00191-3"},{"key":"CIT0258","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1365-8"},{"key":"CIT0259","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.32.6.587"},{"key":"CIT0260","doi-asserted-by":"publisher","DOI":"10.2165\/11317350-000000000-00000"},{"key":"CIT0261","doi-asserted-by":"publisher","DOI":"10.2165\/11317550-000000000-00000"},{"key":"CIT0262","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443100-00001"},{"key":"CIT0263","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522070-00001"},{"key":"CIT0264","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50023"},{"key":"CIT0265","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.129304"},{"key":"CIT0266","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12361"},{"key":"CIT0267","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1584-7"},{"key":"CIT0268","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1150-0"},{"key":"CIT0269","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(96)71594-3"},{"key":"CIT0270","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.05.007"},{"key":"CIT0271","doi-asserted-by":"publisher","DOI":"10.1007\/BF02471566"},{"key":"CIT0272","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0022-3565(25)10423-0","volume":"263","author":"Tanigawara Y","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0273","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0000000000000063"},{"key":"CIT0274","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2015.12"},{"key":"CIT0275","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283557c74"},{"key":"CIT0276","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.61.05.0002"},{"key":"CIT0277","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500040502"},{"key":"CIT0278","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02389.x"},{"key":"CIT0279","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)90177-0"},{"key":"CIT0280","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.38.1.389"},{"key":"CIT0281","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199007000-00004"},{"key":"CIT0282","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.31346"},{"key":"CIT0283","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1995.tb05722.x"},{"key":"CIT0284","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.02.021"},{"key":"CIT0285","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(01)70992-7"},{"key":"CIT0286","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00234-6"},{"key":"CIT0287","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210515"},{"key":"CIT0288","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(00)02553-7"},{"key":"CIT0289","doi-asserted-by":"publisher","DOI":"10.1007\/s00147-003-0615-1"},{"key":"CIT0290","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1288"},{"key":"CIT0291","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e318244a7fd"},{"key":"CIT0292","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199608270-00006"},{"key":"CIT0293","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2003.10.008"},{"key":"CIT0294","doi-asserted-by":"publisher","DOI":"10.1097\/01.ftd.0000151186.91464.7c"},{"key":"CIT0295","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v31.pm9469504"},{"key":"CIT0296","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199529060-00003"},{"key":"CIT0297","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.9.3091-3093.2002"},{"key":"CIT0298","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.01.009"},{"key":"CIT0299","doi-asserted-by":"publisher","DOI":"10.5414\/CPP45524"},{"key":"CIT0300","first-page":"3944","volume":"59","author":"Wandel C","year":"1999","journal-title":"Cancer Res"},{"key":"CIT0301","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/FPC.0b013e32833ea085","volume":"21","author":"Wehland M","year":"2011","journal-title":"Pharmacogenet Genomics"},{"key":"CIT0302","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20709"},{"key":"CIT0303","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.166R011"},{"key":"CIT0304","doi-asserted-by":"publisher","DOI":"10.1038\/nrd753"},{"key":"CIT0305","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1093\/clinchem\/40.12.2247","volume":"40","author":"Winkler M","year":"1994","journal-title":"Clin Chem"},{"key":"CIT0306","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02794.x"},{"key":"CIT0307","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2004.00256.x"},{"key":"CIT0308","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198815050-00002"},{"key":"CIT0309","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(98)00036-9"},{"key":"CIT0310","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.017004"},{"key":"CIT0311","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.105.004358"},{"key":"CIT0312","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-005-0952-3"},{"key":"CIT0313","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1075-7"},{"key":"CIT0314","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022254617664"},{"key":"CIT0315","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200208270-00024"},{"key":"CIT0316","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03656.x"},{"key":"CIT0317","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2009.01181.x"},{"key":"CIT0318","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.64"},{"key":"CIT0319","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.04.008"},{"key":"CIT0320","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90700-9"},{"key":"CIT0321","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018993312773"},{"key":"CIT0322","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.03.009"},{"key":"CIT0323","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.02008.x"},{"key":"CIT0324","doi-asserted-by":"publisher","DOI":"10.1097\/01.ftd.0000170029.36573.a0"},{"key":"CIT0325","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0090-9556(24)15229-4","volume":"27","author":"Zhang QY","year":"1999","journal-title":"Drug Metab Dispos"},{"key":"CIT0326","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.011072"},{"key":"CIT0327","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12122"},{"key":"CIT0328","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3182708edf"},{"key":"CIT0329","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31827e6ad9"},{"key":"CIT0330","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.175"},{"key":"CIT0331","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31815c16f5"},{"key":"CIT0332","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2015.1021733"},{"key":"CIT0333","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200112000-00009"}],"container-title":["Drug Metabolism Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/03602532.2016.1151037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T10:24:42Z","timestamp":1748773482000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.3109\/03602532.2016.1151037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,2]]},"references-count":333,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,2,26]]},"published-print":{"date-parts":[[2016,1,2]]}},"alternative-id":["10.3109\/03602532.2016.1151037"],"URL":"https:\/\/doi.org\/10.3109\/03602532.2016.1151037","relation":{},"ISSN":["0360-2532","1097-9883"],"issn-type":[{"value":"0360-2532","type":"print"},{"value":"1097-9883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idmr20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idmr20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}