{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T22:13:13Z","timestamp":1774995193148,"version":"3.50.1"},"reference-count":146,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Metabolism Reviews"],"published-print":{"date-parts":[[1995,1]]},"DOI":"10.3109\/03602539508998329","type":"journal-article","created":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T14:25:54Z","timestamp":1195223154000},"page":"397-417","source":"Crossref","is-referenced-by-count":198,"title":["Clinical Importance of Hepatic Cytochrome P450 in Drug Metabolism"],"prefix":"10.1080","volume":"27","author":[{"given":"M.","family":"Spatzenegger","sequence":"first","affiliation":[]},{"given":"W.","family":"Jaeger","sequence":"additional","affiliation":[]}],"member":"301","published-online":{"date-parts":[[2008,9,22]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1989.tb03556.x"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040480"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3188-7"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1993.12.1"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1991.tb04708.x"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1002\/cpt19741519"},{"key":"CIT0007","first-page":"7","volume-title":"Human Drug Metabolism","author":"Guengerich F. P.","year":"1992"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90170-N"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(83)90090-9"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90119-P"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199204000-00004"},{"key":"CIT0012","first-page":"332","volume":"3","author":"Kroemer H. K.","year":"1993","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CIT0013","first-page":"1385","volume":"255","author":"Imaoka S.","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0014","first-page":"120","volume":"43","author":"Botsch S.","year":"1993","journal-title":"Mol. Pharmaco."},{"key":"CIT0015","first-page":"153","volume":"45","author":"Ryan D. E.","year":"1990","journal-title":"Pharmac. Rev."},{"key":"CIT0016","first-page":"645","volume":"21","author":"Mani C.","year":"1993","journal-title":"Drug Metab. Dispos."},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/13.5.799"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1021\/tx00036a015"},{"key":"CIT0019","first-page":"939","volume":"21","author":"Jayyosi Z.","year":"1993","journal-title":"Drug Metab. Dispos."},{"key":"CIT0020","first-page":"504","volume":"20","author":"Groen K.","year":"1992","journal-title":"Drug Metab. Dispos."},{"key":"CIT0021","first-page":"131","volume":"18","author":"Juedes M. J.","year":"1990","journal-title":"Drug Metab. Dispos."},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90596-O"},{"key":"CIT0023","first-page":"366","volume":"265","author":"Berson A.","year":"1993","journal-title":"Pharmacol. Exp. Ther."},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1021\/tx00034a019"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1988.tb03393.x"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(89)90151-3"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1002\/chir.530060503"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"7813","DOI":"10.1016\/S0021-9258(17)34443-5","volume":"253","author":"Fasco M. J.","year":"1978","journal-title":"J. Biol. Chem."},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1042\/bj2670365"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"17995","DOI":"10.1016\/S0021-9258(19)81314-5","volume":"263","author":"Motsunaga T.","year":"1988","journal-title":"J. Biol. Chem."},{"key":"CIT0031","first-page":"5629","volume":"53","author":"Chang T. K. H.","year":"1993","journal-title":"Cancer Res."},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1021\/bi00266a045"},{"key":"CIT0033","first-page":"1210","volume":"55","author":"Faibushevich A. A.","year":"1990","journal-title":"Biokhimiy."},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1016\/S0021-9258(19)41552-4","volume":"250","author":"Hangen D. A.","year":"1975","journal-title":"J. Biol. Chem."},{"key":"CIT0035","first-page":"96","volume":"20","author":"Boelsterli U. A.","year":"1992","journal-title":"Drug Metab. Dispos."},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90239-2"},{"key":"CIT0037","first-page":"797","volume":"20","author":"Corcos L","year":"1992","journal-title":"Drug Metab. Dispos."},{"key":"CIT0038","first-page":"595","volume":"18","author":"Pichard L.","year":"1990","journal-title":"Drug Metab. Dispos."},{"key":"CIT0039","first-page":"A11","volume":"265","author":"Murray M.","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0040","first-page":"852","volume":"15","author":"Ciaccio P. J.","year":"1987","journal-title":"Drug Metab. Dispos."},{"key":"CIT0041","first-page":"736","volume":"35","author":"Reidy G. F.","year":"1989","journal-title":"Mol. Pharmacol."},{"key":"CIT0042","first-page":"10","volume":"35","author":"Lunetta J. M.","year":"1989","journal-title":"Mol. Pharmacol."},{"key":"CIT0043","first-page":"1267","volume":"44","author":"Goeptar A. R.","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"CIT0044","first-page":"2344","volume":"49","author":"Clarke L.","year":"1989","journal-title":"Cancer Res."},{"key":"CIT0045","first-page":"121","volume":"45","author":"Bachmann K.","year":"1992","journal-title":"Pharmacolog."},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.15369\/sujms1989.4.7"},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0889-8553(21)00046-7","volume":"21","author":"Watkins P. B","year":"1992","journal-title":"Gastroenterol. Clin. N."},{"key":"CIT0048","first-page":"89","volume":"264","author":"Yasumori T.","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1021\/bi00418a039"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90333-E"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1007\/BF00548400"},{"key":"CIT0052","first-page":"386","volume":"54","author":"Cresteil Th.","year":"1994","journal-title":"Cancer Res."},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.39"},{"key":"CIT0054","first-page":"1450","volume":"260","author":"Chang T.","year":"1992","journal-title":"J. Pharmacol. Exp. Tlier."},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90293-E"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1994.65"},{"key":"CIT0057","first-page":"2344","volume":"49","author":"Lynn C.","year":"1989","journal-title":"Cancer Res."},{"key":"CIT0058","first-page":"572","volume":"22","author":"Vage C.","year":"1994","journal-title":"Drug Metab. Dispos."},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1016\/S0021-9258(19)89213-X","volume":"261","author":"Guengerich F. P.","year":"1986","journal-title":"J. Biol. Chem."},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1977225part1573"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1991.tb05499.x"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90226-F"},{"key":"CIT0063","doi-asserted-by":"crossref","first-page":"9315","DOI":"10.1016\/S0021-9258(18)34071-7","volume":"257","author":"Dieter H. H.","year":"1982","journal-title":"J. Biol. Chem."},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.55"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1021\/bi00337a023"},{"key":"CIT0066","first-page":"379","volume":"20","author":"Jaruratanasirikul S.","year":"1992","journal-title":"Drug Met-ab. Dispos."},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.3109\/03602539109029764"},{"key":"CIT0068","author":"Tucker G. T","year":"1994","journal-title":"J. Pharm. Pharmacol., 46, All"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90362-9"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90333-Z"},{"key":"CIT0071","first-page":"789","volume":"259","author":"Turgeon J.","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.23"},{"key":"CIT0073","first-page":"111","volume":"82","author":"Bolaji O. O.","year":"1993","journal-title":"Res. Commun. Chem. Pathol."},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1991.tb03902.x"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1991.tb05588.x"},{"key":"CIT0076","first-page":"1355","volume":"260","author":"Fischer V.","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0077","first-page":"658","volume":"32","author":"Crewe H. K.","year":"1991","journal-title":"Br. J. Clin. Pharmacol."},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1986.56"},{"key":"CIT0079","first-page":"343","author":"Feifel N.","year":"1991","journal-title":"Naunyn-Schmiedebergs Arch. Pharmacol."},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(94)90156-2"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1007\/BF00610381"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1994.tb04293.x"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.3109\/00498259109039472"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.3109\/00498259209053134"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1994.tb04294.x"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.109"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.3109\/00498259109044400"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316110"},{"key":"CIT0089","doi-asserted-by":"crossref","first-page":"8472","DOI":"10.1016\/S0021-9258(18)34356-4","volume":"237","author":"Koop D. R.","year":"1982","journal-title":"J. Biol. Chem."},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1139\/y91-081"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1021\/bi00370a001"},{"key":"CIT0092","first-page":"148","volume":"33","author":"Brady J. F.","year":"1988","journal-title":"Mol. Pharmaco."},{"key":"CIT0093","first-page":"454","volume":"246","author":"Gruenke L. D.","year":"1988","journal-title":"J. Pharmacol Exp. Ther."},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199310000-00023"},{"key":"CIT0095","first-page":"37","volume":"20","author":"Sarkar M. A.","year":"1992","journal-title":"Drug Metab. Dispos."},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(91)90125-X"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2215"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1021\/tx00016a015"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1989.tb03516.x"},{"key":"CIT0100","first-page":"1047","volume":"41","author":"Pichard L.","year":"1992","journal-title":"Mol. Pharmaco."},{"key":"CIT0101","first-page":"352","volume":"45","author":"Relling M. V.","year":"1994","journal-title":"Mol. Pharmaco."},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90711-5"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.18.6310"},{"key":"CIT0104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9258(17)44323-7","volume":"258","author":"Waxman D. J.","year":"1983","journal-title":"J. Biol. Chem."},{"key":"CIT0105","first-page":"595","volume":"18","author":"Pichard L.","year":"1990","journal-title":"Drug Metab. Dispos."},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199209000-00011"},{"key":"CIT0107","first-page":"1845","volume":"6","author":"Ha H. A.","year":"1992","journal-title":"FASEB J."},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(93)90152-M"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90304-2"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90313-3"},{"key":"CIT0111","first-page":"1","volume":"266","author":"Cook C. S.","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90674-8"},{"key":"CIT0113","first-page":"187","volume":"51","author":"LeDue B.","year":"1992","journal-title":"Clin. Pharmacol. Ther."},{"key":"CIT0114","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1152\/ajpcell.1992.262.4.C927","volume":"262","author":"Watlington O.","year":"1992","journal-title":"Am. J. Physiol."},{"key":"CIT0115","first-page":"140","volume":"32","author":"Fleming C. M.","year":"1990","journal-title":"Pharmacolog."},{"key":"CIT0116","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000480616","volume":"18","author":"Jacqz-Aigrain E.","year":"1992","journal-title":"Dev. Pharmacol. Ther."},{"key":"CIT0117","first-page":"859","volume":"40","author":"Eberhart D. C.","year":"1991","journal-title":"Mol. Pharmacol."},{"key":"CIT0118","first-page":"711","volume":"18","author":"Pichard L.","year":"1990","journal-title":"Drug Metab. Dispos."},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90075-T"},{"key":"CIT0120","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1016\/S0021-9258(19)89213-X","volume":"261","author":"Guengerich F. P.","year":"1986","journal-title":"J. Biol. Chem."},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(93)90115-F"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(91)90551-S"},{"key":"CIT0123","first-page":"215","volume":"28","author":"Shimada T.","year":"1985","journal-title":"Mol. Pharmacol."},{"key":"CIT0124","first-page":"381","volume":"261","author":"Flinois J. P.","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1021\/tx00001a009"},{"key":"CIT0126","first-page":"287","volume":"30","author":"Guengerich F. P.","year":"1986","journal-title":"Mol. Pharmacol."},{"key":"CIT0127","first-page":"753","volume":"20","author":"Sattler M.","year":"1992","journal-title":"Drug Metab. Dispos."},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1255"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90654-F"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90131-N"},{"key":"CIT0131","first-page":"403","volume":"21","author":"Yun C. H.","year":"1993","journal-title":"Drug Metab. Dispos."},{"key":"CIT0132","first-page":"241","volume":"20","author":"Bornheim L. M.","year":"1992","journal-title":"Drug Metab. Dispos."},{"key":"CIT0133","first-page":"89","volume":"36","author":"Kronbach T.","year":"1989","journal-title":"Mol. Pharmaco."},{"key":"CIT0134","first-page":"124","volume":"343","author":"Kroemer H. K.","year":"1991","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CIT0135","first-page":"5121","volume":"53","author":"Zhou R.","year":"1993","journal-title":"Cancer Res."},{"key":"CIT0136","author":"Nakasa H.","year":"1993","journal-title":"Mol. Pharmacol., 44,216"},{"key":"CIT0137","first-page":"280","volume":"42","author":"Bourdi M.","year":"1992","journal-title":"Mol. Pharmacol."},{"key":"CIT0138","first-page":"348","volume":"270","author":"Nims R. W.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90015-O"},{"key":"CIT0140","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.2570070308"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90176-J"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.5.942"},{"key":"CIT0143","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.16.428"},{"key":"CIT0144","unstructured":"Strobl G., Heinrich B., Wolff T., Guengerich F. P. Cytochrome P-450: Biochemistry and Biophysics. Taylor and Francis, London 1989; 407"},{"key":"CIT0145","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(90)90741-G"},{"key":"CIT0146","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(91)90125-X"}],"container-title":["Drug Metabolism Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/03602539508998329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T01:03:54Z","timestamp":1630112634000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.3109\/03602539508998329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":146,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,9,22]]},"published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.3109\/03602539508998329"],"URL":"https:\/\/doi.org\/10.3109\/03602539508998329","relation":{},"ISSN":["0360-2532","1097-9883"],"issn-type":[{"value":"0360-2532","type":"print"},{"value":"1097-9883","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}