{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:25:45Z","timestamp":1752549945321},"reference-count":106,"publisher":"Informa UK Limited","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[1995,1]]},"DOI":"10.3109\/07853899509019250","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T01:26:09Z","timestamp":1195694769000},"page":"641-651","source":"Crossref","is-referenced-by-count":6,"title":["Pathogenesis, Clinical Picture and Treatment of von Willebrand's Disease"],"prefix":"10.1080","volume":"27","author":[{"given":"Stefan R.","family":"Lethagen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"CIT0001","first-page":"88","volume":"67","author":"von Willebrand E A","year":"1926","journal-title":"Finska L\u00e4k-S\u00e4llsk Handl"},{"key":"CIT0002","first-page":"551","volume":"32","author":"Alexander B","year":"1953","journal-title":"J Clin Invest"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1542\/peds.18.3.347","volume":"18","author":"Schulman L","year":"1956","journal-title":"Pediatrics"},{"key":"CIT0004","first-page":"1654","volume":"56","author":"Nilsson I M","year":"1956","journal-title":"Nord Med"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.0954-6820.1959.tb00189.x","volume":"164","author":"Nilsson I M","year":"1959","journal-title":"Acta Med Scand"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.0954-6820.1957.tb00123.x","volume":"159","author":"Nilsson I M","year":"1957","journal-title":"Acta Med Scand"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/324270a0","volume":"324","author":"Bonthron D T","year":"1986","journal-title":"Nature"},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1172\/JCI112129","volume":"76","author":"Fowler W E","year":"1985","journal-title":"J Clin Invest"},{"key":"CIT0009","first-page":"27","volume":"69","author":"Wagner D D","year":"1987","journal-title":"Stood"},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1055\/s-0038-1649724","volume":"70","author":"Journet A M","year":"1993","journal-title":"Thromb Haemost"},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1073\/pnas.88.7.2946","volume":"88","author":"Ware J","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1126\/science.3486471","volume":"232","author":"Fay P J","year":"1986","journal-title":"Science"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1002\/j.1460-2075.1987.tb02591.x","volume":"6","author":"Verweij C L","year":"1987","journal-title":"EMBO J"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/j.1460-2075.1993.tb05709.x","volume":"12","author":"Voorberg J","year":"1993","journal-title":"EMBO J"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1182\/blood.V69.5.1531.1531","volume":"69","author":"Sporn L A","year":"1987","journal-title":"Blood"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/279636a0","volume":"279","author":"Sakariassen K S","year":"1979","journal-title":"Nature"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1083\/jcb.99.6.2123","volume":"99","author":"Wagner D D","year":"1984","journal-title":"J Cell Biol"},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1084\/jem.141.5.1101","volume":"141","author":"Nachman R L","year":"1975","journal-title":"J Exp Med"},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0049-3848(74)90218-7","volume":"4","author":"Howard M A","year":"1974","journal-title":"Thromb Res"},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1182\/blood.V60.5.1132.1132","volume":"60","author":"Lopez Fernandez M F","year":"1982","journal-title":"Blood"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI110946","volume":"72","author":"Ruggeri Z M","year":"1983","journal-title":"J Clin Invest"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1182\/blood.V77.11.2305.2305","volume":"77","author":"Colombatti A","year":"1991","journal-title":"Blood"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"13835","DOI":"10.1016\/S0021-9258(19)76501-6","volume":"262","author":"Pareti Fl","year":"1987","journal-title":"J Biol Chem"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"17901","DOI":"10.1016\/S0021-9258(19)81299-1","volume":"263","author":"Mohri H","year":"1988","journal-title":"J Biol Chem"},{"key":"CIT0025","doi-asserted-by":"crossref","first-page":"11144","DOI":"10.1021\/bi00160a027","volume":"31","author":"Berndt M C","year":"1992","journal-title":"Biochemistry"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"8057","DOI":"10.1073\/pnas.82.23.8057","volume":"82","author":"Plow E F","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1172\/JCI113721","volume":"82","author":"Koedam J A","year":"1988","journal-title":"J Clin Invest"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"8443","DOI":"10.1016\/S0021-9258(18)47430-3","volume":"262","author":"Foster P A","year":"1987","journal-title":"J Biol Chem"},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/bj2820129","volume":"282","author":"Layet S","year":"1992","journal-title":"Biochem J"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1182\/blood.V82.2.663.663","volume":"82","author":"Matsui T","year":"1993","journal-title":"Blood"},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1182\/blood.V69.6.1691.1691","volume":"69","author":"Gill J C","year":"1987","journal-title":"Blood"},{"key":"CIT0032","first-page":"296","volume":"83","author":"Tschopp T B","year":"1974","journal-title":"J Clin Lab Med"},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1182\/blood.V51.2.267.267","volume":"51","author":"Weiss H J","year":"1978","journal-title":"Blood"},{"key":"CIT0034","first-page":"750","volume":"92","author":"Weiss H J","year":"1979","journal-title":"J Clin Lab Med"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1182\/blood.V63.1.128.128","volume":"63","author":"Sixma J J","year":"1984","journal-title":"Blood"},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1749-6632.1987.tb30989.x","volume":"509","author":"Meyer D","year":"1987","journal-title":"Ann NY Acad Sci"},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"7424","DOI":"10.1073\/pnas.82.21.7424","volume":"82","author":"De Marco L","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"CIT0038","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI111673","volume":"75","author":"Gralnlck H R","year":"1985","journal-title":"J Clin Invest"},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1182\/blood.V68.1.58.58","volume":"68","author":"Gralnlck H R","year":"1986","journal-title":"Blood"},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1126\/science.2821619","volume":"238","author":"Rousiahti E","year":"1987","journal-title":"Science"},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1182\/blood.V66.4.796.796","volume":"66","author":"Mannucci P M","year":"1985","journal-title":"Blood"},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1182\/blood.V67.2.322.322","volume":"67","author":"Weiss H J","year":"1986","journal-title":"Blood"},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1055\/s-0038-1646014","volume":"58","author":"Parker Rl","year":"1987","journal-title":"Thromb Haemost"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1038\/312337a0"},{"key":"CIT0045","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/312342a0","volume":"312","author":"Toole J J","year":"1984","journal-title":"Nature"},{"key":"CIT0046","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0167-4838(86)90208-6","volume":"871","author":"Fay P J","year":"1986","journal-title":"Biochim Biophys Acta"},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1172\/JCI113721","volume":"82","author":"Koedam J A","year":"1988","journal-title":"J Clin Invest"},{"key":"CIT0048","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1172\/JCI108146","volume":"56","author":"Cooper H A","year":"1975","journal-title":"J Clin Invest"},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2141.1982.tb03888.x","volume":"52","author":"Tuddenham E GO","year":"1982","journal-title":"Br J Haematol"},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1016\/S0021-9258(18)68793-9","volume":"263","author":"Kaufman R J","year":"1988","journal-title":"J Biol Chem"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1600-0609.1992.tb00584.x","volume":"48","author":"Holmberg L","year":"1992","journal-title":"Eur J Haematol"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood.V69.2.454.454","volume":"69","author":"Rodeghlero F","year":"1987","journal-title":"Blood"},{"key":"CIT0053","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0022-3476(05)80384-1","volume":"123","author":"Werner E J","year":"1993","journal-title":"J Pediatr"},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1055\/s-0038-1649634","volume":"70","author":"Lethagen S","year":"1993","journal-title":"Thromb Haemost"},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1172\/JCI109795","volume":"65","author":"Ruggeri Z M","year":"1980","journal-title":"J Clin Invest"},{"key":"CIT0056","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1182\/blood.V57.6.1140.1140","volume":"57","author":"Ruggeri Z M","year":"1981","journal-title":"Blood"},{"key":"CIT0057","first-page":"75","volume":"54","author":"Chow R","year":"1985","journal-title":"Thromb Haemost"},{"key":"CIT0058","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1055\/s-0038-1651343","volume":"34","author":"Macfarlane D E","year":"1975","journal-title":"Thrombos Diathes Haemorrh"},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/0049-3848(78)90268-2","volume":"12","author":"Zuzel M","year":"1978","journal-title":"Thromb Res"},{"key":"CIT0060","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1056\/NEJM198005083021902","volume":"302","author":"Ruggeri Z M","year":"1980","journal-title":"N Engl J Med"},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1055\/s-0038-1642471","volume":"71","author":"Sadler J E","year":"1994","journal-title":"Thromb Haemost"},{"key":"CIT0062","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/0140-6736(93)91070-3","volume":"341","author":"Eikenboom J CJ","year":"1993","journal-title":"Lancet"},{"key":"CIT0063","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1365-2141.1983.tb02165.x","volume":"55","author":"Hoyer L W","year":"1983","journal-title":"Br J Haematol"},{"key":"CIT0064","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1182\/blood.V66.6.1423.1423","volume":"66","author":"Ciavarella G","year":"1985","journal-title":"Blood"},{"key":"CIT0065","first-page":"215","volume-title":"Coagulation and Bleeding Disorders","author":"Berkowitz S D","year":"1989"},{"key":"CIT0066","first-page":"102","volume-title":"Factor VIII - von Willebrand Factor. Clinical Aspects of Deficiency States","author":"Nilsson I M","year":"1989"},{"key":"CIT0067","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1172\/JCI116735","volume":"923","author":"Murata M","year":"1993","journal-title":"J Clin Invest"},{"key":"CIT0068","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1056\/NEJM198310063091402","volume":"309","author":"Holmberg L","year":"1983","journal-title":"N Engl J Med"},{"key":"CIT0069","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1182\/blood.V68.3.668.668","volume":"68","author":"Holmberg L","year":"1986","journal-title":"Blood"},{"key":"CIT0070","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1182\/blood.V68.1.149.149","volume":"68","author":"Weiss H J","year":"1986","journal-title":"Blood"},{"key":"CIT0071","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1056\/NEJM198202113060603","volume":"306","author":"Weiss H J","year":"1982","journal-title":"N Engl J Med"},{"key":"CIT0072","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1182\/blood.V60.3.790.790","volume":"60","author":"Miller J L","year":"1982","journal-title":"Blood"},{"key":"CIT0073","first-page":"172","volume":"76","author":"Mazurler C","year":"1990","journal-title":"Br J Haematol"},{"key":"CIT0074","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-0038-1651577","volume":"69","author":"Sadler J E","year":"1993","journal-title":"Thromb Haemost"},{"key":"CIT0075","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1055\/s-0038-1651576","volume":"69","author":"Ginsburg D","year":"1993","journal-title":"Thromb Haemost"},{"key":"CIT0076","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/BF00206958","volume":"94","author":"Schneppenheim R","year":"1994","journal-title":"Hum Genet"},{"key":"CIT0077","doi-asserted-by":"crossref","first-page":"22777","DOI":"10.1016\/S0021-9258(18)54418-5","volume":"34","author":"Sadler E","year":"1991","journal-title":"J Biol Chem"},{"key":"CIT0078","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1182\/blood.V79.10.2507.bloodjournal79102507","volume":"79","author":"Ginsburg D","year":"1992","journal-title":"Blood"},{"key":"CIT0079","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1073\/pnas.91.6.2221","volume":"91","author":"Eikenboom J CJ","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"CIT0080","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1172\/JCI116443","volume":"91","author":"Holmberg L","year":"1993","journal-title":"J Clin Invest"},{"key":"CIT0081","doi-asserted-by":"crossref","first-page":"6377","DOI":"10.1073\/pnas.88.14.6377","volume":"88","author":"Tuley E A","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"CIT0082","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1365-2141.1991.tb04480.x","volume":"78","author":"Gaucher C","year":"1991","journal-title":"Br J Haematol"},{"key":"CIT0083","doi-asserted-by":"crossref","first-page":"13499","DOI":"10.1016\/S0021-9258(18)92725-0","volume":"266","author":"Cacheris P M","year":"1991","journal-title":"J Biol Chem"},{"key":"CIT0084","doi-asserted-by":"crossref","first-page":"19146","DOI":"10.1016\/S0021-9258(18)54972-3","volume":"266","author":"Kroner P A","year":"1991","journal-title":"J Biol Chem"},{"key":"CIT0085","first-page":"363","volume":"27","author":"Cash J D","year":"1974","journal-title":"Br J Haematol"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1975.tb00521.x"},{"key":"CIT0087","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF02215950","volume":"69","author":"Lethagen S","year":"1994","journal-title":"Ann Hematol"},{"key":"CIT0088","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0609.1992.tb00906.x","volume":"49","author":"Lethagen S","year":"1992","journal-title":"Eur J Haematol"},{"key":"CIT0089","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-0038-1648407","volume":"67","author":"Lethagen S","year":"1992","journal-title":"Thromb Haemost"},{"key":"CIT0090","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(77)91197-7","volume":"1","author":"Mannuccl P M","year":"1977","journal-title":"Lancet"},{"key":"CIT0091","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2141.1981.tb02789.x","volume":"47","author":"Mannuccl P M","year":"1981","journal-title":"Br J Haematol"},{"key":"CIT0092","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1055\/s-0038-1646050","volume":"58","author":"Lethagen S","year":"1987","journal-title":"Thromb Haemost"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1007\/BF01720274"},{"key":"CIT0094","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2141.1992.tb04598.x","volume":"82","author":"Mannuccl P M","year":"1992","journal-title":"Br J Haematol"},{"key":"CIT0095","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1001\/jama.1976.03270250038023","volume":"236","author":"Blatt P M","year":"1976","journal-title":"JAMA"},{"key":"CIT0096","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1651-2227.1976.tb16525.x","volume":"65","author":"Nilsson I M","year":"1976","journal-title":"Acta Paediatr Scand"},{"key":"CIT0097","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF01836069","volume":"65","author":"Lethagen S","year":"1992","journal-title":"Ann Hematol"},{"key":"CIT0098","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0140-6736(66)92985-0","author":"Bennett E","year":"1966","journal-title":"Lancet"},{"key":"CIT0099","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1056\/NEJM198704093161505","volume":"316","author":"Schimpf K","year":"1987","journal-title":"N Engl J Med"},{"key":"CIT0100","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-0609.1988.tb00825.x","volume":"40","author":"Berntorp E","year":"1988","journal-title":"Eur J Haematol"},{"key":"CIT0101","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1423-0410.1989.tb02031.x","volume":"56","author":"Berntorp E","year":"1989","journal-title":"Vox Sang"},{"key":"CIT0102","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1365-2141.1990.tb02654.x","volume":"75","author":"Pasi K J","year":"1990","journal-title":"Br J Haematol"},{"key":"CIT0103","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1365-2141.1990.tb02655.x","volume":"75","author":"Cummlng A M","year":"1990","journal-title":"Br J Haematol"},{"key":"CIT0104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1423-0410.1991.tb00918.x","volume":"61","author":"Mazurler C","year":"1991","journal-title":"Vox Sang"},{"key":"CIT0105","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1365-2141.1992.tb08903.x","volume":"80","author":"Goudemand J","year":"1992","journal-title":"Br J Haematol"},{"key":"CIT0106","first-page":"3130","volume":"79","author":"Mannucci P M","year":"1992","journal-title":"Stood"}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/07853899509019250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T12:45:16Z","timestamp":1708346716000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.3109\/07853899509019250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":106,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,7,8]]},"published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.3109\/07853899509019250"],"URL":"https:\/\/doi.org\/10.3109\/07853899509019250","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"value":"0785-3890","type":"print"},{"value":"1365-2060","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}