{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T14:28:38Z","timestamp":1794580118224,"version":"4.9.1"},"reference-count":71,"publisher":"Informa UK Limited","issue":"1-2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Ophthalmology"],"published-print":{"date-parts":[[2016,3,3]]},"DOI":"10.3109\/08820538.2015.1115255","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T19:03:09Z","timestamp":1457550189000},"page":"85-90","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":19,"title":["Immunologic Mediators in Stevens\u2013Johnson Syndrome and Toxic Epidermal Necrolysis"],"prefix":"10.3109","volume":"31","author":[{"given":"Hajirah N.","family":"Saeed","sequence":"first","affiliation":[{"name":"Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Chodosh","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61112-X"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.06.004"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.136796"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31822b0f29"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01119.x"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311906"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1884"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680250078010"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.04.048"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1272\/jnms1923.64.459"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212188200"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5388.490"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.10-RAI-0261"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0198-031"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.2.677"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/428486a"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.06.003"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64284-8"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.013"},{"issue":"1","key":"e_1_3_2_21_1","first-page":"3","article-title":"Clinical significance of serum soluble Fas ligand in patients with acute self-limited and fulminant hepatitis","volume":"101","author":"Shiota G","year":"1998","unstructured":"Shiota G, Oyama K, Noguchi N, et al. Clinical significance of serum soluble Fas ligand in patients with acute self-limited and fulminant hepatitis. Research Communications in Molecular Pathology and Pharmacology 1998;101(1):3\u201312","journal-title":"Research Communications in Molecular Pathology and Pharmacology"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700648"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07211.x"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0294-8"},{"issue":"44","key":"e_1_3_2_25_1","first-page":"1656","article-title":"Fas-mediated cell death in toxic epidermal necrolysis and graft-versus-host disease: potential for therapeutic inhibition","volume":"130","author":"French LE","year":"2000","unstructured":"French LE, Tschopp J. Fas-mediated cell death in toxic epidermal necrolysis and graft-versus-host disease: potential for therapeutic inhibition. Schweizerische Medizinische Wochenschrift 2000;130(44):1656\u20131661","journal-title":"Schweizerische Medizinische Wochenschrift"},{"issue":"7","key":"e_1_3_2_26_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1742-1241.2003.tb10578.x","article-title":"Treatment of toxic epidermal necrolysis with intravenous immunoglobulin","volume":"57","author":"Sidwell RU","year":"2003","unstructured":"Sidwell RU, Swift S, Yan CL, et al. Treatment of toxic epidermal necrolysis with intravenous immunoglobulin. International Journal of Clinical Practice 2003;57(7):643\u2013645","journal-title":"International Journal of Clinical Practice"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.127249"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.26"},{"issue":"3","key":"e_1_3_2_29_1","first-page":"383","article-title":"[Use of intravenous immunoglobulin for the treatment of toxic epidermal necrolysis and Stevens\u2013Johnson\/toxic epidermal necrolysis overlap syndrome. Review of 15 cases]","volume":"137","author":"Molgo M","year":"2009","unstructured":"Molgo M, Carreno N, Hoyos-Bachiloglu R, et al. [Use of intravenous immunoglobulin for the treatment of toxic epidermal necrolysis and Stevens\u2013Johnson\/toxic epidermal necrolysis overlap syndrome. Review of 15 cases]. Revista Medica de Chile 2009;137(3):383\u2013389","journal-title":"Revista Medica de Chile"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12423"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12702"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.03.024"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.33"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000105096.93526.27"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701653"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.039"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04166.x"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.08.013"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2013.27.5.331"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins6010194"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01622.x"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.120563"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.07.047"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/377446a0"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.0059"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.09.029"},{"issue":"1","key":"e_1_3_2_47_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.5070\/D397D8T291","article-title":"Treatment of severe drug reactions: Stevens\u2013Johnson syndrome, toxic epidermal necrolysis and hypersensitivity syndrome","volume":"8","author":"Ghislain PD","year":"2002","unstructured":"Ghislain PD, Roujeau JC. Treatment of severe drug reactions: Stevens\u2013Johnson syndrome, toxic epidermal necrolysis and hypersensitivity syndrome. Dermatology Online Journal 2002;8(1):5","journal-title":"Dermatology Online Journal"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051063"},{"issue":"1","key":"e_1_3_2_49_1","first-page":"61","article-title":"Toxic epidermal necrolysis successfully treated with infliximab","volume":"23","author":"Zarate-Correa LC","year":"2013","unstructured":"Zarate-Correa LC, Carrillo-Gomez DC, Ramirez-Escobar AF, Serrano-Reyes C. Toxic epidermal necrolysis successfully treated with infliximab. Journal of Investigational Allergology & Clinical Immunology 2013;23(1):61\u201363","journal-title":"Journal of Investigational Allergology & Clinical Immunology"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06721.x"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018112"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.07.016"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014560012"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.040"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690180043007"},{"issue":"5","key":"e_1_3_2_56_1","first-page":"537","article-title":"[Analysis of treatments and deceased cases of severe adverse drug reactions: analysis of 46 cases of Stevens\u2013Johnson syndrome and toxic epidermal necrolysis]","volume":"58","author":"Yamane Y","year":"2009","unstructured":"Yamane Y, Aihara M, Tatewaki S, et al. [Analysis of treatments and deceased cases of severe adverse drug reactions: analysis of 46 cases of Stevens\u2013Johnson syndrome and toxic epidermal necrolysis]. Arerugi = [Allergy]. 2009;58(5):537\u2013547","journal-title":"Arerugi = [Allergy]"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0214"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.2500\/108854100778250914"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.510"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198611000-00001"},{"issue":"3","key":"e_1_3_2_61_1","first-page":"273","article-title":"Burn center care for patients with toxic epidermal necrolysis","volume":"180","author":"Kelemen JJ","year":"1995","unstructured":"Kelemen JJ 3rd, Cioffi WG, McManus WF, et al. Burn center care for patients with toxic epidermal necrolysis. Journal of the American College of Surgeons 1995;180(3):273\u2013278","journal-title":"Journal of the American College of Surgeons"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00816.x"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-004-0506-z"},{"issue":"4","key":"e_1_3_2_64_1","first-page":"1758","article-title":"Granulysin-induced apoptosis","volume":"161","author":"Gamen S","year":"1998","unstructured":"Gamen S, Hanson DA, Kaspar A, et al. Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways. Journal of Immunology 1998;161(4):1758\u20131764","journal-title":"I. Involvement of at least two distinct pathways. Journal of Immunology"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00970.x"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)01234-2"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003409"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.9.5243"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2010.02.001"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.7439\/ijbr.v4i9.305"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1155"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2556"}],"container-title":["Seminars in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/08820538.2015.1115255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T12:17:47Z","timestamp":1753100267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.3109\/08820538.2015.1115255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,3]]},"references-count":71,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2016,3,3]]}},"alternative-id":["10.3109\/08820538.2015.1115255"],"URL":"https:\/\/doi.org\/10.3109\/08820538.2015.1115255","relation":{},"ISSN":["0882-0538","1744-5205"],"issn-type":[{"value":"0882-0538","type":"print"},{"value":"1744-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=isio20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=isio20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2015-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}