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Bacteriol."},{"key":"CIT0080","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/318191a0","volume":"318","author":"Samson Belagaje S. M.","year":"1985","journal-title":"Cephalosporium acremonium, Nature (London)"},{"key":"CIT0081","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/nbt1187-1207","volume":"5","author":"Samson Dotzlaf S. M.","year":"1987","journal-title":"Biotechnology"},{"key":"CIT0082","first-page":"257","volume":"48","author":"Carr Skatrud L. G.","year":"1986","journal-title":"Penicillium chrysogenum, Gene"},{"key":"CIT0083","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/BF00259395","volume":"221","author":"Montenegro Barredo E.","year":"1990","journal-title":"Mol. Gen. Genet."},{"key":"CIT0084","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1128\/jb.176.8.2473-2475.1994","volume":"176","author":"Tsukamoto Fujii N.","year":"1994","journal-title":"Streptomyces galilaeus, J. Bacteriol."},{"key":"CIT0085","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.7164\/antibiotics.45.1286","volume":"45","author":"Tsukamoto Fujii N.","year":"1992","journal-title":"Streptomyces galilaeus, J. Antibiot."},{"key":"CIT0087","first-page":"1351","volume":"140","author":"Niemi Ylihonko J.","year":"1994","journal-title":"Streptomyces galilaeus, Microbiology"},{"key":"CIT0088","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1128\/jb.175.12.3876-3886.1993","volume":"175","author":"Decker Motamedi H.H.","year":"1993","journal-title":"J. Bacteriol."},{"key":"CIT0089","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1128\/jb.174.11.3651-3658.1992","volume":"174","author":"Guilfoile P.","year":"1992","journal-title":"J. Bacteriol."},{"key":"CIT0090","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1128\/jb.174.11.3659-3666.1992","volume":"174","author":"Guilfoile P.","year":"1991","journal-title":"J. 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Microbiol."},{"key":"CIT0097","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/BF00334395","volume":"216","author":"Smith Bull D. J.","year":"1989","journal-title":"Mol. Gen. Genet."},{"key":"CIT0098","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1002\/j.1460-2075.1990.tb07461.x","volume":"9","author":"Smith Earl D. J.A. J.","year":"1990","journal-title":"EMBO J."},{"key":"CIT0099","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1128\/jb.173.19.6223-6229.1991","volume":"173","author":"Tobin Kovacevic M. B.","year":"1991","journal-title":"J. Bacteriol."},{"key":"CIT0100","first-page":"291","volume":"83","author":"Barredo VanSolingen J. L.","year":"1989","journal-title":"Penicillium chrysogenum, Gene"},{"key":"CIT0101","first-page":"A2","volume":"378","author":"Malshman N. J.","year":"1991","journal-title":"EP 0437"},{"key":"CIT0102","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/325818a0","volume":"325","author":"Malpartida Halam F.","year":"1987","journal-title":"Nature, (London)"},{"key":"CIT0103","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1002\/j.1460-2075.1989.tb08414.x","volume":"8","author":"Bibb Biro M. J.","year":"1989","journal-title":"EMBO J."},{"key":"CIT0104","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/348176a0","volume":"348","author":"Cortes Haydock J.","year":"1990","journal-title":"Saccharopolyspora erythraea, Nature (London)"},{"key":"CIT0105","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1126\/science.2024119","volume":"252","author":"Donadio Staver S.","year":"1991","journal-title":"Science"},{"key":"CIT0106","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0168-9525(93)90067-R","volume":"9","author":"Reeves P","year":"1993","journal-title":"Trends Genet."},{"key":"CIT0107","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1574-6968.1992.tb05149.x","volume":"90","author":"Stockmann M.","year":"1992","journal-title":"FEMS Microbiol. Lett."},{"key":"CIT0108","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0378-1119(89)90421-6","volume":"85","author":"Epp Huber J. 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