{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:22:52Z","timestamp":1790281372428,"version":"4.1.0"},"reference-count":100,"publisher":"Informa UK Limited","issue":"sup2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia & Lymphoma"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.3109\/10428190903383427","type":"journal-article","created":{"date-parts":[[2010,6,18]],"date-time":"2010-06-18T15:34:13Z","timestamp":1276875253000},"page":"16-26","source":"Crossref","is-referenced-by-count":22,"title":["Advances in treatment of chronic myelogenous leukemia \u2013 new treatment options with tyrosine kinase inhibitors"],"prefix":"10.1080","volume":"50","author":[{"given":"Fabio P. S.","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Ravandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2009,12,17]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood.V96.10.3343","volume":"96","author":"Deininger MW","year":"2000","journal-title":"Blood"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907153410306"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-144790"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904293401706"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(89)90024-6"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.21.1616"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1182\/blood.V80.5.1352.1352","volume":"80","author":"Biggs JC","year":"1992","journal-title":"Blood"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3097"},{"key":"CIT0010","first-page":"4236","volume":"62","author":"Nagar B","year":"2002","journal-title":"Cancer Res"},{"key":"CIT0011","first-page":"100","volume":"56","author":"Buchdunger E","year":"1996","journal-title":"Cancer Res"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1182\/blood.V90.12.4947","volume":"90","author":"Carroll M","year":"1997","journal-title":"Blood"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1038\/nm0596-561"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-3565(24)38879-2","volume":"295","author":"Buchdunger E","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441402"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441401"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011573"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3530"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.6.1928"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022457"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21032"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-004325"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11831"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-158535"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70342-X"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20922"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-005686"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062538"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.531"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404318"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.9.3472"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.3.1014"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00096-X"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-066936"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-003-0741-6"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.03.050"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-036012"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116475"},{"key":"CIT0039","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V112.11.4255.4255","volume":"112","author":"Ault P","year":"2008","journal-title":"Blood"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4276"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0694"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-4687"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602402103"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000126200"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V101.2.690"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-1484"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402290200"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1021\/jm049486a"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4187"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099480"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0259"},{"key":"CIT0052","first-page":"159","volume":"46","author":"Lee FY","year":"2005","journal-title":"Proc Am Assoc Cancer Res"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2050"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055229"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.84"},{"key":"CIT0056","volume":"110","author":"Guilhot F","year":"2007","journal-title":"Blood"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.221"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-056028"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.9260"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.11.001"},{"key":"CIT0061","volume":"108","author":"Quintas-Cardama A","year":"2006","journal-title":"Blood"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.0329"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11410"},{"key":"CIT0064","volume":"110","author":"Quintas-Cardama A","year":"2007","journal-title":"Blood"},{"key":"CIT0065","volume":"110","author":"Quintas-Cardama A","year":"2007","journal-title":"Blood"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.01.007"},{"key":"CIT0067","first-page":"1408","volume":"46","author":"Manley PW","year":"2005","journal-title":"Proc Am Assoc Cancer Res"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055104"},{"key":"CIT0069","volume":"110","author":"Kantarjian HM","year":"2007","journal-title":"Blood"},{"key":"CIT0070","volume":"112","author":"Kantarjian HM","year":"2008","journal-title":"Blood"},{"key":"CIT0071","volume":"112","author":"le Coutre PD","year":"2008","journal-title":"Blood"},{"key":"CIT0072","volume":"110","author":"Giles FJ","year":"2007","journal-title":"Blood"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-073528"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404827"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.47"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0117"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1199"},{"key":"CIT0078","volume":"112","author":"Cortes J","year":"2008","journal-title":"Blood"},{"key":"CIT0079","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V112.11.1101.1101","volume":"112","author":"Passerini CG","year":"2008","journal-title":"Blood"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.8853"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2209"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-013250"},{"key":"CIT0083","volume":"110","author":"Kantarjian HM","year":"2007","journal-title":"Blood"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1245"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023789416385"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-025049"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-048421"},{"key":"CIT0088","volume":"110","author":"Shah NP","year":"2007","journal-title":"Blood"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-113175"},{"key":"CIT0090","volume":"112","author":"Cortes J","year":"2008","journal-title":"Blood"},{"key":"CIT0091","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V110.11.1030.1030","volume":"110","author":"Paquette RL","year":"2007","journal-title":"Blood"},{"key":"CIT0092","volume":"112","author":"Balabanov S","year":"2008","journal-title":"Blood"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.14.1095"},{"key":"CIT0094","first-page":"263","volume":"2","author":"Cephalotaxine esters in the treatment of acute leukemia","year":"1976","journal-title":"Chin Med J (Engl)"},{"key":"CIT0095","first-page":"319","volume":"3","author":"Harringtonine in Acute Leukemias","year":"1977","journal-title":"Chin Med J (Engl)"},{"key":"CIT0096","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1182\/blood.V86.9.3322.bloodjournal8693322","volume":"86","author":"O'Brien S","year":"1995","journal-title":"Blood"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-05-0164"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22398"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(99)00327-5"},{"key":"CIT0100","volume":"112","author":"Cortes J","year":"2008","journal-title":"Blood"}],"container-title":["Leukemia & Lymphoma"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/10428190903383427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T02:34:56Z","timestamp":1740191696000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.3109\/10428190903383427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":100,"journal-issue":{"issue":"sup2","published-online":{"date-parts":[[2009,12,17]]},"published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.3109\/10428190903383427"],"URL":"https:\/\/doi.org\/10.3109\/10428190903383427","relation":{},"ISSN":["1042-8194","1029-2403"],"issn-type":[{"value":"1042-8194","type":"print"},{"value":"1029-2403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}