{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:34:17Z","timestamp":1791182057927,"version":"4.1.0"},"reference-count":90,"publisher":"Informa UK Limited","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia & Lymphoma"],"published-print":{"date-parts":[[1999,1]]},"DOI":"10.3109\/10428199909058472","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T20:40:13Z","timestamp":1455568813000},"page":"451-461","source":"Crossref","is-referenced-by-count":28,"title":["Effects of Mutant c-Kit in Early Myeloid Cells"],"prefix":"10.3109","volume":"34","author":[{"given":"Leonie K.","family":"Ashman","sequence":"first","affiliation":[{"name":"Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petranel","family":"Ferrao","sequence":"additional","affiliation":[{"name":"Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Cole","sequence":"additional","affiliation":[{"name":"Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony C.","family":"Cambareri","sequence":"additional","affiliation":[{"name":"Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2009,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.1.30.30"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.6.1403.1403"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.2.365.365"},{"key":"e_1_2_1_5_1","first-page":"157","article-title":"c\u2010kit is expressed by primitive human hematopoietic cells that give rise to colony\u2010forming cells in stroma\u2010dependent or cytokine\u2010supplemented culture","volume":"22","author":"Simmons P. J.","year":"1994","unstructured":"Simmons P. J., Aylett G. W., Niutta S., To L. B., Juttner C. A., Ashman L. K. c\u2010kit is expressed by primitive human hematopoietic cells that give rise to colony\u2010forming cells in stroma\u2010dependent or cytokine\u2010supplemented culture. Exper. Hematol. 1994; 22: 157\u2013165","journal-title":"Exper. Hematol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2513"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.150420"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2660(08)60549-0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60508-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.5.1185.1185"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.1.63"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.7.2281"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90116-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.3.1079"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31864-1"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.3887.bloodjournal88103887"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1987.27"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.12.3009.3009"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.9.2237.2237"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.8.2145.2145"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/373347a0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.3.771.771"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.3.3.349"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.3.641.bloodjournal853641"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.4.1345"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.4.1101"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(85)90119-5"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/320415a0"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02655.x"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(88)90021-5"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/335088a0"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90020-7"},{"key":"e_1_2_1_33_1","first-page":"726","volume-title":"Leucocyte Qping III White Cell Differentiation Antigens","author":"Ashman L. K.","year":"1987","unstructured":"Ashman L. K., Gadd S. J., Mayrhofer G., Spargo L. D. J., Cole S. R. A murine monoclonal antibody to an acute myeloid leukaemia\u2010associated cell surface antigen identifies tissue mast cells. Leucocyte Qping III White Cell Differentiation Antigens, A. J. McMichael, et al. Oxford University Press, Oxford 1987; 726\u2013728"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.9.1876.1876"},{"key":"e_1_2_1_35_1","first-page":"854","article-title":"The product of the proto\u2010oncogene c\u2010kit (P145c\u2010kit) is a human bone marrow surface antigen of hemopoietic precursor cells which is expressed on a subset of acute non\u2010lymphoblastic leukemic cells","volume":"5","author":"Buhring H. J.","year":"1991","unstructured":"Buhring H. J., Ullrich A., Schaudt K., Muller C. A., Busch F. W. The product of the proto\u2010oncogene c\u2010kit (P145c\u2010kit) is a human bone marrow surface antigen of hemopoietic precursor cells which is expressed on a subset of acute non\u2010lymphoblastic leukemic cells. Leukemia 1991; 5: 854\u2013860","journal-title":"Leukemia"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.1.60.60"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.11.2962.2962"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.3.750.750"},{"key":"e_1_2_1_39_1","first-page":"288","article-title":"Increased expression of c\u2010Kit or its ligand Steel Factor is not a common feature of adult acute myeloid leukaemia","volume":"10","author":"Cole S. R.","year":"1996","unstructured":"Cole S. R., Aylett G. W., Casey G., Harvey N. L., Cambareri A. C., Ashman L. K. Increased expression of c\u2010Kit or its ligand Steel Factor is not a common feature of adult acute myeloid leukaemia. Leukemia 1996; 10: 288\u2013296","journal-title":"Leukemia"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199409049699"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199509049769"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(88)90020-3"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.3.847.847"},{"key":"e_1_2_1_44_1","first-page":"258","article-title":"AML: immunophenotypic heterogeneity and prognostic significance of c\u2010kit expression","volume":"8","author":"Reuss\u2010Borst M. A.","year":"1994","unstructured":"Reuss\u2010Borst M. A., Buhring H. J., Schmidt H., Muller C. A. AML: immunophenotypic heterogeneity and prognostic significance of c\u2010kit expression. Leukemia 1994; 8: 258\u2013263","journal-title":"Leukemia"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400823"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90141-K"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.2.596"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199809057558"},{"key":"e_1_2_1_49_1","first-page":"1046","article-title":"Synergistic action of interleukin\u20102 and Steel factor (SLF) on a human T lympho\u2010blastoid cell line","volume":"9","author":"Kees U. R.","year":"1995","unstructured":"Kees U. R., Ashman L. K. Synergistic action of interleukin\u20102 and Steel factor (SLF) on a human T lympho\u2010blastoid cell line. Leukemia 1995; 9: 1046\u20131050","journal-title":"Leukemia"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1996.tb08993.x"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.3.785.785"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.5.1199.1199"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2461"},{"key":"e_1_2_1_54_1","first-page":"1436","article-title":"c\u2010kit ligand stimulates tyrosine phosphorylation of the c\u2010Cbl protein in human hematopoietic cells","volume":"10","author":"Wisniewski D.","year":"1996","unstructured":"Wisniewski D., Strife A., Clarkson B. c\u2010kit ligand stimulates tyrosine phosphorylation of the c\u2010Cbl protein in human hematopoietic cells. Leukemia 1996; 10: 1436\u20131442","journal-title":"Leukemia"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.6102053.x"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116761"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(88)90050-1"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.9.2619.2619"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236870"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.1.273.273"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.8.3117.bloodjournal8783117"},{"key":"e_1_2_1_62_1","first-page":"189","article-title":"Transforming and differentiation\u2010inducing potential of constitutively activated C\u2010kit mutant genes in the IC\u20102 murine interleukin\u20103\u2010epen\u2010dent mast cell line","volume":"148","author":"Hashimoto K.","year":"1996","unstructured":"Hashimoto K., Tsujimura T., Moriyama Y., Yamatodani A., Kimura M., Tohya K., Morimoto M., Kitayama H., Kanakura Y., Kitamura Y. Transforming and differentiation\u2010inducing potential of constitutively activated C\u2010kit mutant genes in the IC\u20102 murine interleukin\u20103\u2010epen\u2010dent mast cell line. Am. J. Path. 1996; 148: 189\u2013200","journal-title":"Am. J. Path."},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0396-312"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.23.10560"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050439"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.d01-2042.x"},{"key":"e_1_2_1_67_1","first-page":"498","article-title":"Absence of point mutations in a functionally important part of the extracellular domain of the c\u2010kit proto\u2010oncogene in a series of patients with acute myeloid leukemia (AML)","volume":"8","author":"Arland M.","year":"1994","unstructured":"Arland M., Fiedler W., Samalecos A., Hossfeld D. K. Absence of point mutations in a functionally important part of the extracellular domain of the c\u2010kit proto\u2010oncogene in a series of patients with acute myeloid leukemia (AML). Leukemia 1994; 8: 498\u2013501","journal-title":"Leukemia"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05364.x"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199709114167"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.1998.0191"},{"key":"e_1_2_1_71_1","first-page":"107","volume-title":"Cancer Cytogenetics","author":"Heim S.","year":"1995","unstructured":"Heim S., Mitelman F. Cancer Cytogenetics. Wiley Liss Inc., New York 1995; 107"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.2.701"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.11.4539"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90301-T"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201494"},{"key":"e_1_2_1_76_1","first-page":"1631","article-title":"Enforced expression of full length c\u2010Myb leads to density\u2010dependent transformation of murine haemopoietic cells","volume":"11","author":"Ferrao P.","year":"1995","unstructured":"Ferrao P., Macmillan E. M., Ashman L. K., Gonda T. J. Enforced expression of full length c\u2010Myb leads to density\u2010dependent transformation of murine haemopoietic cells. Oncogene 1995; 11: 1631\u20131638","journal-title":"Oncogene"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14665"},{"key":"e_1_2_1_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.12.6573"},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.3.790.bloodjournal853790"},{"issue":"3","key":"e_1_2_1_80_1","first-page":"396","article-title":"Mechanisms of constitutive activation of c\u2010kit receptor tyrosine kinase","volume":"11","author":"Tsujimura T.","year":"1997","unstructured":"Tsujimura T., Kanakura Y., Kitamura Y. Mechanisms of constitutive activation of c\u2010kit receptor tyrosine kinase. Leukemia 1997; 11(Supplement 3)396\u2013398","journal-title":"Leukemia"},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.7.3347"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7824936"},{"key":"e_1_2_1_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.6.3350-3358.1993"},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0796-309"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.1111"},{"key":"e_1_2_1_86_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.12.7577-7586.1993"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90351-8"},{"key":"e_1_2_1_88_1","first-page":"2291","article-title":"Coexpression of the stem cell factor and the c\u2010kit genes in small\u2010cell lung cancer","volume":"6","author":"Hibi K.","year":"1991","unstructured":"Hibi K., Takahashi T., Sekido Y., Ueda R., Hida T., Ariy\u2010oshi Y., Takagi H. Coexpression of the stem cell factor and the c\u2010kit genes in small\u2010cell lung cancer. Oncogene 1991; 6: 2291\u20132296","journal-title":"Oncogene"},{"key":"e_1_2_1_89_1","first-page":"370","article-title":"Autocrine growth of small cell lung cancer mediated by coexpression of c\u2010kit and stem cell factor","volume":"56","author":"Krystal G. W.","year":"1996","unstructured":"Krystal G. W., Hines S. J., Organ C. P. Autocrine growth of small cell lung cancer mediated by coexpression of c\u2010kit and stem cell factor. Cancer Res. 1996; 56: 370\u2013376","journal-title":"Cancer Res."},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.577"},{"key":"e_1_2_1_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.3.995.995"}],"container-title":["Leukemia & Lymphoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/10428199909058472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:53:38Z","timestamp":1770893618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.3109\/10428199909058472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":90,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.3109\/10428199909058472"],"URL":"https:\/\/doi.org\/10.3109\/10428199909058472","relation":{},"ISSN":["1042-8194","1029-2403"],"issn-type":[{"value":"1042-8194","type":"print"},{"value":"1029-2403","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}