{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:35:02Z","timestamp":1793579702737,"version":"4.5.0"},"reference-count":76,"publisher":"Informa UK Limited","issue":"6","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Free Radical Research"],"published-print":{"date-parts":[[2014,6,1]]},"DOI":"10.3109\/10715762.2014.898842","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T11:26:51Z","timestamp":1393846011000},"page":"659-669","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":27,"title":["Disruption of redox homeostasis and brain damage caused in vivo by methylmalonic acid and ammonia in cerebral cortex and striatum of developing rats"],"prefix":"10.1080","volume":"48","author":[{"given":"C. M.","family":"Viegas","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, UFRGS, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2.","family":"Zanatta","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, UFRGS, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Grings","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, UFRGS, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. H.","family":"Hickmann","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, UFRGS, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. O.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, UFRGS, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. E.","family":"Soares","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, UFRGS, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2.","family":"Sitta","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Gen\u00e9tica M\u00e9dica, Hospital de Cl\u00ednicas de Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Leipnitz","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, UFRGS, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. H.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Patologia, Hospital de Cl\u00ednicas de Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wajner","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, UFRGS, Porto Alegre, RS, Brazil"},{"name":"Servi\u00e7o de Gen\u00e9tica M\u00e9dica, Hospital de Cl\u00ednicas de Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"CIT0001","volume-title":"The metabolic and molecular bases of inherited disease","author":"Fenton WA","year":"2001"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35387"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1007\/BF01957698"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1715"},{"key":"CIT0005","first-page":"1459","volume":"15","author":"Brismar J","year":"1994","journal-title":"AJNR Am J Neuroradiol"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1007\/BF00711749"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1007\/BF00710054"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1572-3"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1177\/088307389501000104"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30090"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243167"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1273720"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.10.003"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00117-5"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00275-3"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.42902.x"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2005.08.005"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00978-8"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.11.038"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.12.017"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.07.012"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-011-9675-4"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.08.075"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-011-9324-0"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(99)00127-6"},{"key":"CIT0026","first-page":"1143","volume":"42","author":"de Mello CF","year":"1997","journal-title":"Biochem Mol Biol Int"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70080-X"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83434-1"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1021\/pr050481r"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21107"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2010.01.002"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-011-9736-8"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9084-8"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1007\/BF01805805"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-121848"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200002280-00023"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2011.02.002"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9545-3"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.1998.0263"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2005.11.016"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.09.026"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010395724012"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9426-1"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1977.tb07623.x"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-012-9327-5"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.10.112"},{"key":"CIT0047","volume-title":"The rat brain in stereotaxic coordinates","author":"Paxinos G","year":"1986"},{"key":"CIT0048","first-page":"143","volume-title":"Techniques in Diagnostic Human Biochemical Genetics: A Laboratory Manual","author":"Sweetman L","year":"1991","edition":"1"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.10.007"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2292"},{"key":"CIT0051","first-page":"347","volume":"108","author":"Browne RW","year":"1998","journal-title":"Methods Mol Biol"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01636-6"},{"key":"CIT0053","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/clinchem\/44.3.679","volume":"44","author":"Navarro-Gonz\u00e1lvez JA","year":"1998","journal-title":"Clin Chem"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1021\/tx00026a012"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"CIT0056","first-page":"243","volume-title":"Handbook for Oxygen Radical Research","author":"Marklund S","year":"1985","edition":"1"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(81)77046-0"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(85)13062-4"},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"Lowry OH","year":"1951","journal-title":"J Biol Chem"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02034.x"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1080\/08860220701460426"},{"key":"CIT0062","first-page":"268","volume-title":"Free Radicals in Biology and Medicine","author":"Halliwell B","year":"2007"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812149106"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1261"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07576.x"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03069-4"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005631230455"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200997200"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9546-2"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2008.11.005"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2006.10.009"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)91457-3"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00019-9"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1986.tb00768.x"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02785-2"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2010.07.008"}],"container-title":["Free Radical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/10715762.2014.898842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T04:58:24Z","timestamp":1648443504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.3109\/10715762.2014.898842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":76,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,4,1]]},"published-print":{"date-parts":[[2014,6,1]]}},"alternative-id":["10.3109\/10715762.2014.898842"],"URL":"https:\/\/doi.org\/10.3109\/10715762.2014.898842","relation":{},"ISSN":["1071-5762","1029-2470"],"issn-type":[{"value":"1071-5762","type":"print"},{"value":"1029-2470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,25]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifra20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifra20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2013-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}