{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:08:12Z","timestamp":1770916092161,"version":"3.50.1"},"reference-count":37,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Free Radical Research"],"published-print":{"date-parts":[[1997,1]]},"DOI":"10.3109\/10715769709097800","type":"journal-article","created":{"date-parts":[[2008,3,11]],"date-time":"2008-03-11T13:10:16Z","timestamp":1205241016000},"page":"201-208","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Photofrin\u00ae Photodynamic Action on Mitochondrial Respiration and Superoxide Radical Generation"],"prefix":"10.1080","volume":"26","author":[{"given":"Christian","family":"Salet","sequence":"first","affiliation":[{"name":"Laboratoires de Biophysique et de Photobiologie, INSERM U 201 et CNRS URA 481, Mus\u00e9um National d'Histoire Naturelle, 43 rue Cuvier, 75231, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana","family":"Moreno","sequence":"additional","affiliation":[{"name":"Laboratoires de Biophysique et de Photobiologie, INSERM U 201 et CNRS URA 481, Mus\u00e9um National d'Histoire Naturelle, 43 rue Cuvier, 75231, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Ricchelli","sequence":"additional","affiliation":[{"name":"Centro C.N.R. Metalloproteine, Dipartimento di Biologica, Universit\u00e0 di Padova, Via Trieste 75, 35121, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2009,7,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1993.tb04990.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(94)90248-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1986.tb04697.x"},{"key":"e_1_2_1_5_1","first-page":"211","article-title":"Relationship of mitochondrial function and cellular adenosine triphosphate levels of hematoporphyrin derivative-induced photosensitization in R3230AC mammary tumors","volume":"46","author":"Hilf R.","year":"1986","unstructured":"Hilf R., Murant R. S., Narayanan U., Gibson S. L. Relationship of mitochondrial function and cellular adenosine triphosphate levels of hematoporphyrin derivative-induced photosensitization in R3230AC mammary tumors. Cancer Research 1986; 46: 211\u2013217","journal-title":"Cancer Research"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)91086-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(87)80006-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1751-1097.1994.tb05043.x","article-title":"Hematoporphyrin derivative-induced photodynamic inhibition of Na+\/K+-ATPase in L929 fibroblasts, Chinese hamster ovary cells and T24 human bladder transitional carcinoma cells","volume":"59","author":"Penning L. C.","year":"1994","unstructured":"Penning L. C., Tijssen K., van Stevenick J., Dubbelman T. M. A. R. Hematoporphyrin derivative-induced photodynamic inhibition of Na+\/K+-ATPase in L929 fibroblasts, Chinese hamster ovary cells and T24 human bladder transitional carcinoma cells. Photochemistry and Photobiology 1994; 59: 336\u2013341","journal-title":"Photochemistry and Photobiology"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1994.tb05117.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/rab.47.4.383"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(90)80002-F"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553009514550551"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1982.tb04377.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05060-6"},{"key":"e_1_2_1_15_1","first-page":"311","article-title":"A simple ultraviolet spectrophotometric method for the determination of protein","volume":"48","author":"Waddel W. J.","year":"1956","unstructured":"Waddel W. J., Hill C. A simple ultraviolet spectrophotometric method for the determination of protein. Journal of Laboratory and Clinical Medicine 1956; 48: 311\u2013314","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)45228-9"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1751-1097.1990.tb01701.x","article-title":"Uptake and photodynamic efficiency of hematoporphyrin, hydroxyethylvinyldeuteroporphyrin and hematoporphyrin derivative (Photofrin II): a study with isolated mitochondria","volume":"51","author":"Dellinger M.","year":"1990","unstructured":"Dellinger M., Vever-Bizet C., Brault D., Moreno G., Salet C. Uptake and photodynamic efficiency of hematoporphyrin, hydroxyethylvinyldeuteroporphyrin and hematoporphyrin derivative (Photofrin II): a study with isolated mitochondria. Photochemistry and Photobiology 1990; 51: 185\u2013189","journal-title":"Photochemistry and Photobiology"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41019-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(79)90289-3"},{"key":"e_1_2_1_20_1","first-page":"65","article-title":"The respiratory chain and oxidative phosphorylation","volume":"17","author":"Chance B.","year":"1956","unstructured":"Chance B., Williams G. The respiratory chain and oxidative phosphorylation. Advances in Enzymology 1956; 17: 65\u2013134","journal-title":"Advances in Enzymology"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/266271a0","article-title":"Proton pump coupled to cytochrome c oxidase in mitochondria","volume":"266","author":"Wikstrom M. K","year":"1977","unstructured":"Wikstrom M. K. Proton pump coupled to cytochrome c oxidase in mitochondria. Nature 1977; 266: 271\u2013273","journal-title":"Nature"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(80)90056-0"},{"key":"e_1_2_1_23_1","first-page":"227","article-title":"Photodynamic effects of hematoporphyrin on respiration and calcium uptake in isolated mitochondria","volume":"39","author":"Salet C.","year":"1981","unstructured":"Salet C., Moreno G. Photodynamic effects of hematoporphyrin on respiration and calcium uptake in isolated mitochondria. International Journal of Radiation Biology 1981; 39: 227\u2013230","journal-title":"International Journal of Radiation Biology"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1978.tb06957.x"},{"key":"e_1_2_1_25_1","first-page":"2326","article-title":"Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor","volume":"36","author":"Weishaupt K. R.","year":"1976","unstructured":"Weishaupt K. R., Comer D. J., Dougherty T. J. Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor. Cancer Research 1976; 36: 2326\u20132329","journal-title":"Cancer Research"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1990.tb08676.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1021\/bi00215a033","article-title":"Hematoporphyrin-promoted photoinactixration of mitochondrial ubiquinolcytochrome c reductase: selective destruction of the histidine ligands of the iron-sulfur cluster and protective effect of ubiquinone","volume":"30","author":"Miki T.","year":"1991","unstructured":"Miki T., Yu L., Yu C.-A. Hematoporphyrin-promoted photoinactixration of mitochondrial ubiquinolcytochrome c reductase: selective destruction of the histidine ligands of the iron-sulfur cluster and protective effect of ubiquinone. Biochemistry 1991; 30: 230\u2013238","journal-title":"Biochemistry"},{"key":"e_1_2_1_28_1","first-page":"391","article-title":"Photosensitization of isolated mitochondria by hematoporphyrin derivative (Photofrin): effects on bioenergetics","volume":"53","author":"Salet C.","year":"1991","unstructured":"Salet C., Moreno G., Atlante A., Passarella S. Photosensitization of isolated mitochondria by hematoporphyrin derivative (Photofrin): effects on bioenergetics. Photochemistry and Photobiology 1991; 53: 391\u2013393","journal-title":"Photochemistry and Photobiology"},{"key":"e_1_2_1_29_1","first-page":"4191","article-title":"Photosensitization of mitochondrial cytochrome c oxidase by hematoporphyrin derivative and related porphyrins in vitro and","volume":"43","author":"Gibson S. L.","year":"1983","unstructured":"Gibson S. L., Hilf R. H. Photosensitization of mitochondrial cytochrome c oxidase by hematoporphyrin derivative and related porphyrins in vitro and. in vivo. Cancer Research 1983; 43: 4191\u20134197","journal-title":"in vivo. Cancer Research"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1989.tb04321.x"},{"key":"e_1_2_1_31_1","first-page":"621","article-title":"The use of tetrazolium salts to determine sites of damage to the mitochondrial electron transport chain in intact cells following in vitro photodynamic therapy with Photofrin II","volume":"59","author":"Musser D. A.","year":"1995","unstructured":"Musser D. A., Oseroff A. R. The use of tetrazolium salts to determine sites of damage to the mitochondrial electron transport chain in intact cells following in vitro photodynamic therapy with Photofrin II. Photochemistry and Photobiology 1995; 59: 621\u2013626","journal-title":"Photochemistry and Photobiology"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0006-3002(63)90513-4","article-title":"Studies on succinate-tetrazolium reductase systems. III. Points of coupling of four different tetrazolium salts","volume":"77","author":"Slater T. F.","year":"1963","unstructured":"Slater T. F., Sawyer B., Str\u00fcli U. Studies on succinate-tetrazolium reductase systems. III. Points of coupling of four different tetrazolium salts. Biochimica et Biophysica Acta 1963; 77: 283\u2013293","journal-title":"Biochimica et Biophysica Acta"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(90)90198-O"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)46227-2"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/bbrc.1994.2647","article-title":"Impairment of respiratory functions in mitochondria of rats with an inherited hyperproduction of free radicals","volume":"205","author":"Salganik R. I.","year":"1994","unstructured":"Salganik R. I., Shabalina I. G., Solovyova N. A., Kolosova N. G., Solovyor V. N., Kolpakov A. R. Impairment of respiratory functions in mitochondria of rats with an inherited hyperproduction of free radicals. Biochemical and Biophysical Research Communications 1994; 205: 180\u2013185","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1122"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1342"},{"key":"e_1_2_1_38_1","first-page":"1141","article-title":"Role of superoxide dismutase in cancer: a review","volume":"39","author":"Oberley L. W.","year":"1979","unstructured":"Oberley L. W., Buettner G. R. Role of superoxide dismutase in cancer: a review. Cancer Research 1979; 39: 1141\u20131149","journal-title":"Cancer Research"}],"container-title":["Free Radical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/10715769709097800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:07:17Z","timestamp":1770912437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.3109\/10715769709097800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.3109\/10715769709097800"],"URL":"https:\/\/doi.org\/10.3109\/10715769709097800","relation":{},"ISSN":["1071-5762","1029-2470"],"issn-type":[{"value":"1071-5762","type":"print"},{"value":"1029-2470","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]}}}