{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:02:56Z","timestamp":1757703776672},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"vor","delay-in-days":4895,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Objective<\/jats:bold>: Previous work in our laboratory has shown that retinal vein pressure is significantly greater than intraocular pressure in the cat. Our purpose here is to evaluate the potential of an active mechanism being responsible for the control of vein pressure in the cat retina.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: A double\u2010lumen, concentric barrel micropipette assembly designed for operation within the eye of a spontaneously breathing anesthetized cat was developed. The micropipette, initially filled with hypertonic saline for use with a servonull pressure measuring system, was used to determine intravascular pressure. With the tip of the micropipette still situated in the lumen of the vessel the solution in the micropipette was exchanged for papaverine, a potent smooth muscle dilator. Following vasodilation in the distal portion of a major retinal vein, the papaverine was exchanged for hypertonic saline and intravascular pressures were measured in the dilated vessel.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: Microinjection of papaverine caused visible dilation of the major retinal vein downstream from the site of microinjection. This indicates a relaxation of the smooth muscle yet papaverine caused no change in measured retinal vein pressure.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold>: Vein pressure in the cat retina is maintained above intraocular pressure by mechanisms other than active control. A passive high\u2010resistance segment resides somewhere within the optic nerve possibly within the lamina cribosa or prelaminar region.<\/jats:p>","DOI":"10.3109\/10739689609148300","type":"journal-article","created":{"date-parts":[[2008,4,24]],"date-time":"2008-04-24T22:33:44Z","timestamp":1209076424000},"page":"263-270","source":"Crossref","is-referenced-by-count":2,"title":["Control Mechanisms of Retinal Vein Pressure: Evaluation in the Cat Using an <i>In Situ<\/i> Infusion Micropipette"],"prefix":"10.1111","volume":"3","author":[{"given":"R.","family":"Attariwala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Glucksberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1972.tb06611.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1972.tb05177.x"},{"key":"e_1_2_1_4_1","first-page":"1019","article-title":"The influence of elevated intraocular pressure on vascular pressures in the cat retina","volume":"35","author":"Attariwala R.","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_5_1","first-page":"1401","article-title":"A new technique to measure retinal blood velocity in the cat","volume":"35","author":"Attariwala R.","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.64.1.167"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(64)80034-8"},{"key":"e_1_2_1_8_1","first-page":"1001","volume-title":"The Handbook of Physiology: Cardiovascular System IV","author":"Bill A.","year":"1986"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1990.43"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(92)90067-S"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76847-3"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1139\/y94-049"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0026-2862(68)90012-5","article-title":"Retinal vasculature","volume":"1","author":"Cogan and Kuwabara Friedman","year":"1968","journal-title":"Microvasc Res"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/mvre.1993.1014","article-title":"A micropipette which allows in situ perfusion of arterioles and capillaries","volume":"45","author":"Damon DN","year":"1993","journal-title":"Microvasc Res"},{"key":"e_1_2_1_15_1","first-page":"H965","article-title":"Double\u2010barrel pipette system for microinjection","volume":"253","author":"Davis MJ","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(68)91520-1"},{"key":"e_1_2_1_17_1","first-page":"58","article-title":"Blood flow in the normal human retina","volume":"30","author":"Feke GT","year":"1989","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1136\/bjo.57.12.910","article-title":"Effects of papaverine on the retinal microcirculation","volume":"57","author":"Ffytche TJ","year":"1973","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_1_19_1","first-page":"427","article-title":"Retinal vascular response to breathing increased carbon dioxide and oxygen concentrations","volume":"3","author":"Frayser R.","year":"1964","journal-title":"Invest Ophthal"},{"key":"e_1_2_1_20_1","first-page":"1030","article-title":"Effects of raised intraocular pressure on retinal, prelaminar, laminar, and retrolaminar optic nerve blood flow in monkeys","volume":"18","author":"Geijer C.","year":"1979","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1993.1015"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00919649"},{"key":"e_1_2_1_23_1","first-page":"27","article-title":"Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases","volume":"1","author":"Green WR","year":"1981","journal-title":"Retina"},{"key":"e_1_2_1_24_1","first-page":"2300","article-title":"Quantitative analysis of retinal hemodynamics using targeted dye delivery","volume":"31","author":"Guran T.","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853899309147290"},{"key":"e_1_2_1_26_1","first-page":"194","article-title":"On the mechanism of papaverine inhibition of the voltage dependent Ca++ current in isolated smooth muscle cells from the guinea pig trachea","volume":"263","author":"Iguchi M.","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_27_1","first-page":"204","article-title":"Robotic micromanipulator for ophthalmic surgery","volume":"2","author":"Jensen PS","year":"1994","journal-title":"Proc First Intl Symp Med Robotic Comp Assist Surg"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1139\/y87-354"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32609-X"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.77.8.515"},{"key":"e_1_2_1_31_1","first-page":"1163","article-title":"The influence of cerebrospinal fluid pressure on the lamina cribrosa tissue pressure gradient","volume":"36","author":"Morgan WH","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF00370599","article-title":"A simple method for multiple fluid exchange","volume":"415","author":"Ritter M.","year":"1989","journal-title":"Pfl\u00fcgers Arch"},{"key":"e_1_2_1_33_1","first-page":"1124","article-title":"Blood velocity and volumetric flow rate in human retinal vessels","volume":"26","author":"Riva CE","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_34_1","first-page":"2661","article-title":"Retinal vein occlusion","volume":"45","author":"Robinson MK","year":"1992","journal-title":"Am Fam Physician"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90072-P"},{"key":"e_1_2_1_36_1","first-page":"320","article-title":"Morphometric assessment of the central retinal artery and vein in the optic nerve head","volume":"28","author":"Taylor AW","year":"1993","journal-title":"Can J Ophthalmol"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018678"}],"container-title":["Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F10739689609148300","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/10739689609148300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T02:30:07Z","timestamp":1698373807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.3109\/10739689609148300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,9]]}},"alternative-id":["10.3109\/10739689609148300"],"URL":"https:\/\/doi.org\/10.3109\/10739689609148300","archive":["Portico"],"relation":{},"ISSN":["1073-9688","1549-8719"],"issn-type":[{"value":"1073-9688","type":"print"},{"value":"1549-8719","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,9]]}}}