{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:09:17Z","timestamp":1782727757805,"version":"3.54.5"},"reference-count":45,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T00:00:00Z","timestamp":1458086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Amyloid"],"published-print":{"date-parts":[[2016,4,2]]},"DOI":"10.3109\/13506129.2016.1148025","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T13:33:53Z","timestamp":1458135233000},"page":"86-97","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":81,"title":["Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin"],"prefix":"10.3109","volume":"23","author":[{"given":"Jeffrey N.","family":"Higaki","sequence":"first","affiliation":[{"name":"Prothena Biosciences Inc, South San Francisco, CA, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi","family":"Chakrabartty","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J.","family":"Galant","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Hadley","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Hammerson","sequence":"additional","affiliation":[{"name":"Seattle Genetics, Bothell, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarlochan","family":"Nijjar","sequence":"additional","affiliation":[{"name":"Prothena Biosciences Inc, South San Francisco, CA, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Torres","sequence":"additional","affiliation":[{"name":"Prothena Biosciences Inc, South San Francisco, CA, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R.","family":"Tapia","sequence":"additional","affiliation":[{"name":"Prothena Biosciences Inc, South San Francisco, CA, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Salmans","sequence":"additional","affiliation":[{"name":"Prothena Biosciences Inc, South San Francisco, CA, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Barbour","sequence":"additional","affiliation":[{"name":"Prothena Biosciences Inc, South San Francisco, CA, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Tam","sequence":"additional","affiliation":[{"name":"Prothena Biosciences Inc, South San Francisco, CA, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Prothena Biosciences Inc, South San Francisco, CA, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner","family":"Zago","sequence":"additional","affiliation":[{"name":"Prothena Biosciences Inc, South San Francisco, CA, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene G.","family":"Kinney","sequence":"additional","affiliation":[{"name":"Prothena Biosciences Inc, South San Francisco, CA, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.2271"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1186\/2047-9158-3-19"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308724"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"E2403","DOI":"10.1002\/humu.22619","volume":"35","author":"Rowczenio DM","year":"2014","journal-title":"Hum Mutat"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.3109\/13506120308998998"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-31"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.7.2843"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-014-1499-0"},{"key":"CIT0009","volume-title":"A physician's guide to transthyretin amyloidosis","author":"Coehlo T","year":"2008"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)93127-M"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121005109"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182661eb1"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.283815"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208760"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2012.673140"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.2174\/092986712800269281"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105889"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.261419998"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(96)80089-3"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2014.08.016"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"e52686","DOI":"10.1371\/journal.pone.0052686","volume":"7","author":"Wall JS","year":"2012","journal-title":"PLoS One"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.02.002"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.557231"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700365"},{"key":"CIT0025","first-page":"1301","volume":"144","author":"Gustavsson \u00c5","year":"1994","journal-title":"Am J Pathol"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1042\/bj3480167"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2013.1524"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2012.674075"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.3108"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4220"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1021\/bi800636q"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1021\/bi011194d"},{"key":"CIT0033","first-page":"503","volume":"147","author":"Schmidt ML","year":"1995","journal-title":"Am J Pathol"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1021\/bi500617x"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2381-04.2005"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711664105"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.4109"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.659912"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1038\/78682"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64639-1"},{"key":"CIT0041","first-page":"284","volume":"38","author":"Pepys MB","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12024"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.018"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.6530"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.078915"}],"container-title":["Amyloid"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/13506129.2016.1148025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/13506129.2016.1148025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T01:40:55Z","timestamp":1599356455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.3109\/13506129.2016.1148025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,16]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4,2]]}},"alternative-id":["10.3109\/13506129.2016.1148025"],"URL":"https:\/\/doi.org\/10.3109\/13506129.2016.1148025","relation":{},"ISSN":["1350-6129","1744-2818"],"issn-type":[{"value":"1350-6129","type":"print"},{"value":"1744-2818","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,16]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iamy20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iamy20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2015-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-25","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}