{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:16:48Z","timestamp":1761823008783},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T00:00:00Z","timestamp":1300924800000},"content-version":"vor","delay-in-days":7175,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Lang &amp; Comm Disor"],"published-print":{"date-parts":[[1991,8]]},"abstract":"<jats:title>ABSTRACTS<\/jats:title><jats:p>The purpose of this study was to define more completely the speech disorders that can occur in systemic amyloidosis. Fifty\u2010nine patients with histologically established primary systemic amyloidosis were studied. Of this group, 81% had abnormal voice quality, 43% had abnormal pitch, 7% had abnormal resonation and 15% had abnormal articulation. Twenty\u2010two patients also had abnormal findings at laryngeal examination, consisting of bowing, oedema, thickening, dry irritation and polypoid changes of the vocal folds. Macroglossia was found in 17% of the patients and submandibular swelling in 10%. These results support previous studies which showed that abnormal phonation is a sign of systemic amyloidosis and that abnormal voice is by far the most common abnormal speech sign. The relationship between amyloid deposit and dysphonia was not clear. In 23 patients who had laryngeal examinations, no evidence of actual amyloid deposits was documented.<\/jats:p><jats:p>Le but de cette \u00e9tude \u00e9tait de d\u00e9finir plus compl\u00e8tement les troubles de la parole qui apparaissent pour les amyloses syst\u00e9miques. Cinquante neuf patients, avec des amyloses syst\u00e9miques confirm\u00e9es \u00e0 l'histologie ont \u00e9t\u00e9 \u00e9tudi\u00e9s. Dans ce groupe, 81% avaient une qualit\u00e9 de voix anormale; 43% avaient un pitch anormal; 7% avaient des r\u00e9sonnances anormales; et 15% une articulation anormale. Vingt deux patients avaient aussi des examens laryng\u00e9s anormaux, avec glotte ovalaire, oed\u00e8mati\u00e9e, \u00e9paissie, inflammatoire (s\u00e9cheresse), ou polypo\u00efde. Une macroglossie existait chez 17% des patients et des oed\u00e8mes sousmandibulaires existaient chez 10%. Ces r\u00e9sultats corroborent des \u00e9tudes ant\u00e9rieures qui montraient qu'une phonation anormale est un signe de l'amylose syst\u00e9mique et qu'une voix anormale est de loin le signe le plus courant d'une parole anormale. La relation entre les d\u00e9p\u00f4ts amyloides et la dysphonie n'\u00e9tait pas claire. Chez 23 patients qui avaient subit un examen laryng\u00e9, aucune \u00e9vidence de d\u00e9p\u00f4ts (amyloides) n'a \u00e9t\u00e9 trouv\u00e9e.<\/jats:p><jats:p>Das Ziel dieser Studie war es, die Sprechst\u00f6rungen genauer zu beschreiben, die bei der allgemeinen Amyloidose auftreten. Wir haben 59 Patienten mit histologisch nachweisbarer prim\u00e4rer Amyloidose untersucht. Von diesen Patienten zeigten 81% eine abnorme Stimmqualit\u00e4t; 43% eine abnorme Tonh\u00f6he; 7% eine abnorme Resonation; und 15% abnormale Artikulation. Auch 22 Patienten hatten bei der Kehlkopfuntersuchung einen anormalen Befund \u2010 darunter Biegung, \u00f6dem, Verdickung, trockener Reiz, und polypartige \u00c4nderungen der Stimmfalten. Bei 17% stellten wir eine Makroglossie fest und bei weiteren 10% eine Schwellung unter dem Unterkiefer. Die Ergebnisse fr\u00fcherer Studien werdeun best\u00e4tigt, die gezeigt haben, dass die abnorme Phonation ein Zeichen der allgemeinen Amyloidose sei, und dass eine anorme Stimme die am h\u00e4ufigsten gefundene Sprechst\u00f6rung sei. Die Beziehung zwischen der amyloiden Ablagerung und der Dysphonie war nicht klar. Bei 23 Patienten, die eine largyngale Untersuchung bekamen, konnten wir keine amyloidische Ablagerung beweisen.<\/jats:p>","DOI":"10.3109\/13682829109012003","type":"journal-article","created":{"date-parts":[[2007,11,18]],"date-time":"2007-11-18T01:19:57Z","timestamp":1195348797000},"page":"201-206","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Speech disorders in systemic amyloidosis"],"prefix":"10.1111","volume":"26","author":[{"given":"Elizabeth I.","family":"Burroughs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold E.","family":"Aronson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R.","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Kyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947708600624"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100093658"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510009736X"},{"key":"e_1_2_1_5_1","first-page":"32","article-title":"Diffuse amyloidosis of the larynx","volume":"66","author":"HARDINGHAM M.","year":"1987","journal-title":"Ear, Nose and Throat Journal"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1968.00760060415015"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197507000-00001"},{"key":"e_1_2_1_8_1","first-page":"665","article-title":"Amyloidosis (AL): clinical and laboratory features in 229 cases","volume":"58","author":"KYLE R. A.","year":"1983","journal-title":"Mayo Clinic Proceedings"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100062113"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948409300418"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1984.tb01465.x"}],"container-title":["International Journal of Language &amp; Communication Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F13682829109012003","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/13682829109012003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T03:47:04Z","timestamp":1698032824000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.3109\/13682829109012003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,8]]}},"alternative-id":["10.3109\/13682829109012003"],"URL":"https:\/\/doi.org\/10.3109\/13682829109012003","archive":["Portico"],"relation":{},"ISSN":["1368-2822","1460-6984"],"issn-type":[{"value":"1368-2822","type":"print"},{"value":"1460-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,8]]},"assertion":[{"value":"2011-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}