{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:33:17Z","timestamp":1791657197595,"version":"4.3.4"},"reference-count":34,"publisher":"Informa UK Limited","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutical Biology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.3109\/13880209.2012.738332","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T09:13:13Z","timestamp":1358845993000},"page":"433-440","source":"Crossref","is-referenced-by-count":49,"title":["Icariin delays homocysteine-induced endothelial cellular senescence involving activation of the PI3K\/AKT-eNOS signaling pathway"],"prefix":"10.1080","volume":"51","author":[{"given":"Duan","family":"Xiao-Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chang-Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Jian-Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Wen-Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Bing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2013,1,22]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00109-008-0358-7","volume":"86","author":"Andreassi MG","year":"2008","journal-title":"J Mol Med"},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1038\/sj.cdd.4401451","volume":"11","author":"Austin RC","year":"2004","journal-title":"Cell Death Differ"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-5793(01)02272-4","volume":"493","author":"Breitschopf K","year":"2001","journal-title":"FEBS Lett"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","volume":"410","author":"Chang L","year":"2001","journal-title":"Nature"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"H1729","DOI":"10.1152\/ajpheart.01103.2005","volume":"290","author":"Chen J","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbrc.2008.09.001","volume":"376","author":"Chung BH","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1056\/NEJM199104253241701","volume":"324","author":"Clarke R","year":"1991","journal-title":"N Engl J Med"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2001"},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1152\/japplphysiol.91353.2008","volume":"106","author":"Erusalimsky JD","year":"2009","journal-title":"J Appl Physiol"},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1139\/Y08-082","volume":"86","author":"Farhat N","year":"2008","journal-title":"Can J Physiol Pharmacol"},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/01.ATV.21.2.220","volume":"21","author":"Fenton M","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.exger.2003.09.005","volume":"38","author":"Foreman KE","year":"2003","journal-title":"Exp Gerontol"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MOH.0b013e32832a07bd","volume":"16","author":"Goligorsky MS","year":"2009","journal-title":"Curr Opin Hematol"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1128\/MCB.23.13.4598-4610.2003","volume":"23","author":"Haendeler J","year":"2003","journal-title":"Mol Cell Biol"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pharmthera.2008.09.002","volume":"120","author":"Hayashi T","year":"2008","journal-title":"Pharmacol Ther"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1091\/mbc.E05-04-0301","volume":"16","author":"Hu Y","year":"2005","journal-title":"Mol Biol Cell"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-59745-361-5_3","volume":"371","author":"Itahana K","year":"2007","journal-title":"Methods Mol Biol"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01097"},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1016\/j.yexcr.2008.01.011","volume":"314","author":"Lu T","year":"2008","journal-title":"Exp Cell Res"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1161\/01.CIR.0000013836.85741.17","volume":"105","author":"Minamino T","year":"2002","journal-title":"Circulation"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.bbrc.2005.10.053","volume":"338","author":"Perez-de-Arce K","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1080\/10715760701297354","volume":"41","author":"Peshavariya HM","year":"2007","journal-title":"Free Radic Res"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/cbf.1467","volume":"26","author":"Shan H","year":"2008","journal-title":"Cell Biochem Funct"},{"key":"CIT0025","first-page":"117","volume":"21","author":"Song YH","year":"2008","journal-title":"Int J Mol Med"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1161\/01.RES.87.7.540","volume":"87","author":"Vasa M","year":"2000","journal-title":"Circ Res"},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s00109-009-0509-5","volume":"87","author":"von Figura G","year":"2009","journal-title":"J Mol Med"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.phrs.2005.02.023","volume":"52","author":"Wang YK","year":"2005","journal-title":"Pharmacol Res"},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0014-5793(00)01278-3","volume":"470","author":"Xu D","year":"2000","journal-title":"FEBS Lett"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/FJC.0b013e3180325abe","volume":"49","author":"Xu HB","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jep.2007.05.029","volume":"113","author":"Yap SP","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0047-6374(02)00095-7","volume":"123","author":"Yoon SO","year":"2002","journal-title":"Mech Ageing Dev"},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.bone.2006.10.026","volume":"40","author":"Zhang G","year":"2007","journal-title":"Bone"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"11303","DOI":"10.1074\/jbc.M412072200","volume":"280","author":"Zhou H","year":"2005","journal-title":"J Biol Chem"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.yjmcc.2006.01.011","volume":"40","author":"Zhu JH","year":"2006","journal-title":"J Mol Cell Cardiol"}],"container-title":["Pharmaceutical Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/13880209.2012.738332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T02:03:55Z","timestamp":1498010635000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.3109\/13880209.2012.738332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,22]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,1,22]]},"published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.3109\/13880209.2012.738332"],"URL":"https:\/\/doi.org\/10.3109\/13880209.2012.738332","relation":{},"ISSN":["1388-0209","1744-5116"],"issn-type":[{"value":"1388-0209","type":"print"},{"value":"1744-5116","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,22]]}}}