{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:42:14Z","timestamp":1791348134593,"version":"4.3.1"},"reference-count":401,"publisher":"Informa UK Limited","issue":"5","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2015,9,3]]},"DOI":"10.3109\/14756366.2014.966704","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T14:03:17Z","timestamp":1414418597000},"page":"689-721","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":98,"title":["Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium"],"prefix":"10.1080","volume":"30","author":[{"given":"Erik O.","family":"Pettersen","sequence":"first","affiliation":[{"name":"Department of Physics, University of Oslo, Oslo, Norway,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ebbesen","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Oslo, Oslo, Norway,"},{"name":"Laboratory for Stem Cell Research, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roben G.","family":"Gieling","sequence":"additional","affiliation":[{"name":"Manchester Pharmacy School, University of Manchester, Manchester, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaye J.","family":"Williams","sequence":"additional","affiliation":[{"name":"Manchester Pharmacy School, University of Manchester, Manchester, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Dubois","sequence":"additional","affiliation":[{"name":"Manchester Pharmacy School, University of Manchester, Manchester, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lambin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (MaastRO), GROW \u2013 School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Ward","sequence":"additional","affiliation":[{"name":"Western General Hospital, University of Edinburgh, Edinburgh, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Meehan","sequence":"additional","affiliation":[{"name":"Western General Hospital, University of Edinburgh, Edinburgh, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Kunkler","sequence":"additional","affiliation":[{"name":"Western General Hospital, University of Edinburgh, Edinburgh, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P.","family":"Langdon","sequence":"additional","affiliation":[{"name":"Western General Hospital, University of Edinburgh, Edinburgh, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne H.","family":"Ree","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Institute for Cancer Research, Oslo, Norway,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjersti","family":"Flatmark","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Institute for Cancer Research, Oslo, Norway,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Lyng","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Institute for Cancer Research, Oslo, Norway,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Calzada","sequence":"additional","affiliation":[{"name":"Hospital University Princesa, Madrid, Spain,"},{"name":"Department of Medicine, Catedratico de Immunologica, Universidad Autonoma Madrid, Madrid, Spain,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis del","family":"Peso","sequence":"additional","affiliation":[{"name":"Hospital University Princesa, Madrid, Spain,"},{"name":"Department of Medicine, Catedratico de Immunologica, Universidad Autonoma Madrid, Madrid, Spain,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel O.","family":"Landazuri","sequence":"additional","affiliation":[{"name":"Hospital University Princesa, Madrid, Spain,"},{"name":"Department of Medicine, Catedratico de Immunologica, Universidad Autonoma Madrid, Madrid, Spain,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"G\u00f6rlach","sequence":"additional","affiliation":[{"name":"German Heart Center, Technical University Munich, Munich, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Flamm","sequence":"additional","affiliation":[{"name":"Department of Microsystems Engineering, IMTEK, University of Freiburg, Freiburg, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Kieninger","sequence":"additional","affiliation":[{"name":"Department of Microsystems Engineering, IMTEK, University of Freiburg, Freiburg, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Microsystems Engineering, IMTEK, University of Freiburg, Freiburg, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Weltin","sequence":"additional","affiliation":[{"name":"Department of Microsystems Engineering, IMTEK, University of Freiburg, Freiburg, Germany,"},{"name":"Jobst Technologies GmbH, Freiburg, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean C.","family":"Singleton","sequence":"additional","affiliation":[{"name":"CRUK Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Haider","sequence":"additional","affiliation":[{"name":"CRUK Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca M.","family":"Buffa","sequence":"additional","affiliation":[{"name":"CRUK Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian L.","family":"Harris","sequence":"additional","affiliation":[{"name":"CRUK Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[{"name":"Laboratorio di Chimica Bioinorganica, Polo Scientifico, Universit\u00e0 degli Studi di Firenze, Sesto Fiorentino, Florence, Italy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Universit\u00e0 degli Studi di Firenze, Sesto Fiorentino, Florence, Italy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Moser","sequence":"additional","affiliation":[{"name":"Jobst Technologies GmbH, Freiburg, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Jobst","sequence":"additional","affiliation":[{"name":"Jobst Technologies GmbH, Freiburg, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Busk","sequence":"additional","affiliation":[{"name":"Department of Experimental Clinical Oncology, Aarhus University Hospital (AUH), Aarhus, Denmark,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Toustrup","sequence":"additional","affiliation":[{"name":"Department of Experimental Clinical Oncology, Aarhus University Hospital (AUH), Aarhus, Denmark,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Department of Experimental Clinical Oncology, Aarhus University Hospital (AUH), Aarhus, Denmark,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Alsner","sequence":"additional","affiliation":[{"name":"Department of Experimental Clinical Oncology, Aarhus University Hospital (AUH), Aarhus, Denmark,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Pouyssegur","sequence":"additional","affiliation":[{"name":"CNRS, IRCAN, University of Nice, Nice, France,"},{"name":"Centre Scientifique de Monaco, MC, Monaco,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Chiche","sequence":"additional","affiliation":[{"name":"CNRS, IRCAN, University of Nice, Nice, France,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Mazure","sequence":"additional","affiliation":[{"name":"CNRS, IRCAN, University of Nice, Nice, France,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibtissam","family":"Marchiq","sequence":"additional","affiliation":[{"name":"CNRS, IRCAN, University of Nice, Nice, France,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Parks","sequence":"additional","affiliation":[{"name":"CNRS, IRCAN, University of Nice, Nice, France,"},{"name":"Centre Scientifique de Monaco, MC, Monaco,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshan","family":"Ahmed","sequence":"additional","affiliation":[{"name":"The Rayne Instutute, University College London, London, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Ashcroft","sequence":"additional","affiliation":[{"name":"The Rayne Instutute, University College London, London, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pastorekova","sequence":"additional","affiliation":[{"name":"Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihai","family":"Cao","sequence":"additional","affiliation":[{"name":"Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper M.","family":"Rouschop","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (MaastRO), GROW \u2013 School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad G.","family":"Wouters","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (MaastRO), GROW \u2013 School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands,"},{"name":"Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Koritzinsky","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (MaastRO), GROW \u2013 School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands,"},{"name":"Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Mujcic","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Cojocari","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,10,27]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.24.9533"},{"key":"CIT0002","first-page":"5031","volume":"50","author":"Young SD","year":"1990","journal-title":"Cancer Res"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1967"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"20130676","DOI":"10.1259\/bjr.20130676","volume":"87","author":"McKeown SR","year":"2014","journal-title":"Br J Radiol"},{"key":"CIT0005","first-page":"833","volume":"68","author":"Connett RJ","year":"1990","journal-title":"J Appl Physiol (Bethesda, MD)"},{"key":"CIT0006","first-page":"8903","volume":"61","author":"Cairns RA","year":"2001","journal-title":"Cancer Res"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"C1172","DOI":"10.1152\/ajpcell.1996.271.4.C1172","volume":"271","author":"Jiang BH","year":"1996","journal-title":"Am J Physiol"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-9-105-606"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-26-312-638"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1955.55"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(63)90318-8"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9055-1"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1158\/1078-0432.CCR-10-1360","volume":"16","author":"Lu X","year":"2010","journal-title":"Clin Cancer Res"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1205"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386503-8.00001-6"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1002\/embr.201337642"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.200"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.3.768"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1038\/srep00788"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.17.6624"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.640319"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.06159.x"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.07.015"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"e45708","DOI":"10.1371\/journal.pone.0045708","volume":"7","author":"Villar D","year":"2012","journal-title":"PLoS One"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr842"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7359-2_11"},{"key":"CIT0027","first-page":"7075","volume":"60","author":"Wykoff CC","year":"2000","journal-title":"Cancer Res"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-2520"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00400"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.286062"},{"key":"CIT0031","first-page":"271","volume":"4","author":"Csaderova L","year":"2013","journal-title":"Frontier Physiol"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.2174\/138161210793429832"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.2174\/187152009788680028"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.05.045"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4261"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-358"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.047"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.10.008"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.07.015"},{"key":"CIT0040","unstructured":"Balsa E, Acosta-Iborra B, Tello D, et al. HIF-dependent vs. independent mechanisms that regulate Complex IV and oxygen consumption in hypoxia. 2014; submitted for publication"},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nrc2501","volume":"8","author":"Wouters BG","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600998"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.06.036"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600777"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00105-9"},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1083\/jcb.201307185","volume":"203","author":"Koritzinsky M","year":"2013","journal-title":"J Cell Biol"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-062209-093836"},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S1097-2765(02)00696-2","volume":"10","author":"Tu BP","year":"2002","journal-title":"Mol Cell"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40027"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800102200"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1038\/cdd.2008.84","volume":"15","author":"Papandreou I","year":"2008","journal-title":"Cell Death Differ"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5338"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070188"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505801102"},{"key":"CIT0056","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1038\/onc.2010.191","volume":"29","author":"Rzymski T","year":"2010","journal-title":"Oncogene"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.06.015"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20120972"},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.radonc.2009.06.029","volume":"92","author":"Rouschop KMA","year":"2009","journal-title":"Radiother Oncol"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.304576"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210633110"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.3.680"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3196"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0526"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.08.017"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1038\/nature05610"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1038\/nature11412"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1606"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.06.005"},{"key":"CIT0070","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1158\/0008-5472.CAN-12-3109","volume":"73","author":"Atkins C","year":"2013","journal-title":"Cancer Res"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2010.01048.x"},{"key":"CIT0072","doi-asserted-by":"crossref","first-page":"E869","DOI":"10.1073\/pnas.1115623109","volume":"109","author":"Cross BC","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1177\/1087057111414893"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-303099"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1038\/nature07661"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1094"},{"key":"CIT0077","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1021\/jm300713s","volume":"55","author":"Axten JM","year":"2012","journal-title":"J Med Chem"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00498"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E06-09-0830"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210269200"},{"key":"CIT0081","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0076-6879(07)35022-2","volume":"435","author":"Gorlach A","year":"2007","journal-title":"Methods Enzymol"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2011.10.006"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.03.034"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04691.x"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2005"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.10.054"},{"key":"CIT0087","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.freeradbiomed.2007.03.028","volume":"43","author":"Lambeth JD","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3026"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2005"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.50.32253"},{"key":"CIT0091","first-page":"5089","volume":"62","author":"Welsh SJ","year":"2002","journal-title":"Cancer Res"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400265101"},{"key":"CIT0093","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.1038\/sj.onc.1208986","volume":"24","author":"Wang M","year":"2005","journal-title":"Oncogene"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2004.019"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000258979.92828.bc"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3014"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1161\/hh1301.092678"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001914200"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1693"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh227"},{"key":"CIT0101","doi-asserted-by":"crossref","first-page":"26765","DOI":"10.1016\/S0021-9258(19)61441-9","volume":"275","author":"Richard DE","year":"2000","journal-title":"J Biol Chem"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.094060"},{"key":"CIT0103","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-5793(02)02247-0","volume":"512","author":"Stiehl DP","year":"2002","journal-title":"FEBS Lett"},{"key":"CIT0104","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0014-5793(01)02833-2","volume":"505","author":"Haddad JJ","year":"2001","journal-title":"FEBS Lett"},{"key":"CIT0105","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1160\/TH08-07-0473","volume":"100","author":"Diebold I","year":"2008","journal-title":"Thromb Haemost"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-04-0277"},{"key":"CIT0107","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1161\/CIRCRESAHA.109.196592","volume":"104","author":"Diebold I","year":"2009","journal-title":"Circ Res"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3339"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006646107"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.02.071"},{"key":"CIT0111","doi-asserted-by":"crossref","first-page":"10823","DOI":"10.1158\/0008-5472.CAN-07-0783","volume":"67","author":"Xia C","year":"2007","journal-title":"Cancer Res"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611569200"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2105"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090606"},{"key":"CIT0115","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.cell.2004.08.025","volume":"118","author":"Gerald D","year":"2004","journal-title":"Cell"},{"key":"CIT0116","first-page":"1764","volume":"63","author":"Knowles HJ","year":"2003","journal-title":"Cancer Res"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00507-4"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E07-06-0612"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20091609"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2009.06.029"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-307637"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.2174\/138161209789649420"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1038\/nature06905"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080476"},{"key":"CIT0125","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1042\/BJ20080920","volume":"412","author":"Gorlach A","year":"2008","journal-title":"Biochem J"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-04-0391"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5286"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3013"},{"key":"CIT0129","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1182\/blood-2010-08-303669","volume":"117","author":"Fatrai S","year":"2011","journal-title":"Blood"},{"key":"CIT0130","first-page":"1541","volume":"60","author":"Zhong H","year":"2000","journal-title":"Cancer Res"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.12.3995-4004.2001"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.09.036"},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22788"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209114200"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1437"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.333"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000261657.76299.ff"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2005.10.008"},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-012-0963-3"},{"key":"CIT0140","doi-asserted-by":"crossref","first-page":"e19847","DOI":"10.1371\/journal.pone.0019847","volume":"6","author":"Nair D","year":"2011","journal-title":"PLoS One"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.03.008"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.06.009"},{"key":"CIT0143","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1048"},{"key":"CIT0144","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2011"},{"key":"CIT0145","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000154279.98244.eb"},{"key":"CIT0146","doi-asserted-by":"crossref","first-page":"L2","DOI":"10.1152\/ajplung.00135.2005","volume":"290","author":"Liu JQ","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"CIT0147","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0337OC"},{"key":"CIT0148","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E09-12-1003"},{"key":"CIT0149","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.148015"},{"key":"CIT0150","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1057"},{"key":"CIT0151","doi-asserted-by":"crossref","unstructured":"Kieninger J DA, Aravindalochanan K, Jobst G, et al. Amperometric oxygen sensor array with novel chronoamperometric protocols for hypoxic tumor cell cultures. TRANSDUCERS and EUROSENSORS \u201807 \u2013 4th International Conference on Solid-State Sensors, Actuators and Microsystems 4300531; Lyon; pp. 1907\u201310","DOI":"10.1109\/SENSOR.2007.4300531"},{"key":"CIT0152","doi-asserted-by":"publisher","DOI":"10.1080\/14756360902784425"},{"key":"CIT0153","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2013.12089.x"},{"key":"CIT0154","doi-asserted-by":"publisher","DOI":"10.1021\/ac950630x"},{"key":"CIT0155","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh204"},{"key":"CIT0156","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3137"},{"key":"CIT0157","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061131"},{"key":"CIT0158","doi-asserted-by":"publisher","DOI":"10.1126\/science.201025"},{"key":"CIT0159","doi-asserted-by":"publisher","DOI":"10.1126\/science.3375810"},{"key":"CIT0160","doi-asserted-by":"publisher","DOI":"10.1016\/0956-5663(92)87004-9"},{"key":"CIT0161","doi-asserted-by":"publisher","DOI":"10.1016\/S0956-5663(00)00069-5"},{"key":"CIT0162","doi-asserted-by":"publisher","DOI":"10.1021\/ac034641z"},{"key":"CIT0163","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelechem.2005.11.024"},{"key":"CIT0164","doi-asserted-by":"publisher","DOI":"10.1016\/0956-5663(96)89087-7"},{"key":"CIT0165","doi-asserted-by":"publisher","DOI":"10.1016\/S0956-5663(00)00065-8"},{"key":"CIT0166","doi-asserted-by":"publisher","DOI":"10.1016\/S0956-5663(01)00123-3"},{"key":"CIT0167","doi-asserted-by":"publisher","DOI":"10.1016\/s0956-5663(97)00136-x"},{"key":"CIT0168","doi-asserted-by":"publisher","DOI":"10.1039\/b308888j"},{"key":"CIT0169","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.12.027"},{"key":"CIT0170","doi-asserted-by":"publisher","DOI":"10.1517\/17460440903018840"},{"key":"CIT0171","doi-asserted-by":"publisher","DOI":"10.1039\/C3LC50759A"},{"key":"CIT0172","doi-asserted-by":"publisher","DOI":"10.1016\/j.jala.2008.01.004"},{"key":"CIT0173","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-5535(04)00183-2"},{"key":"CIT0174","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-5535(03)00018-2"},{"key":"CIT0175","doi-asserted-by":"publisher","DOI":"10.1016\/j.jala.2007.12.003"},{"key":"CIT0176","doi-asserted-by":"publisher","DOI":"10.1016\/j.jala.2011.01.002"},{"key":"CIT0177","doi-asserted-by":"publisher","DOI":"10.1177\/1087057111413920"},{"key":"CIT0178","doi-asserted-by":"publisher","DOI":"10.1089\/gen.33.01.20"},{"key":"CIT0179","doi-asserted-by":"publisher","DOI":"10.1016\/j.jala.2008.02.002"},{"key":"CIT0180","doi-asserted-by":"publisher","DOI":"10.1021\/ac3027228"},{"key":"CIT0181","doi-asserted-by":"publisher","DOI":"10.1263\/jbb.100.502"},{"key":"CIT0182","first-page":"8","author":"Yeo D","year":"2013","journal-title":"PLoS ONE"},{"key":"CIT0183","first-page":"s4","volume":"24","author":"Adams T","year":"2011","journal-title":"BioPharm Int"},{"key":"CIT0184","volume-title":"Application note 29-0051-80 AA and 28-9606-57 AC","author":"Sciences GEHL","year":"2012"},{"key":"CIT0185","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-011-9336-y"},{"key":"CIT0186","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/AEM.57.4.918-923.1991","volume":"57","author":"Kleman GL","year":"1991","journal-title":"Appl Environ Microbiol"},{"key":"CIT0187","doi-asserted-by":"publisher","DOI":"10.1016\/S0956-5663(01)00298-6"},{"key":"CIT0188","doi-asserted-by":"publisher","DOI":"10.1002\/cite.201200129"},{"key":"CIT0189","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399409001173"},{"key":"CIT0190","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40283"},{"key":"CIT0191","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4453"},{"key":"CIT0192","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0274"},{"key":"CIT0193","doi-asserted-by":"publisher","DOI":"10.1021\/jm301847z"},{"key":"CIT0194","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.06.009"},{"key":"CIT0195","doi-asserted-by":"publisher","DOI":"10.1021\/ja402993u"},{"key":"CIT0196","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.131"},{"key":"CIT0197","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4738"},{"key":"CIT0198","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC48189A"},{"key":"CIT0199","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1128\/MCB.00959-08","volume":"29","author":"Yang J","year":"2009","journal-title":"Mol Cell Biol"},{"key":"CIT0200","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.42"},{"key":"CIT0201","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.10.8326"},{"key":"CIT0202","doi-asserted-by":"publisher","DOI":"10.1038\/nrc864"},{"key":"CIT0203","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.7.2905-2914.2004"},{"key":"CIT0204","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1158\/1535-7163.MCT-07-0442","volume":"7","author":"Supiot S","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"CIT0205","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.11.002"},{"key":"CIT0206","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092472"},{"key":"CIT0207","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.RES.0000253975.76198.ff","volume":"100","author":"Secchiero P","year":"2007","journal-title":"Circ Res"},{"key":"CIT0208","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1158\/0008-5472.CAN-06-2710","volume":"67","author":"LaRusch GA","year":"2007","journal-title":"Cancer Res"},{"key":"CIT0209","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.42"},{"key":"CIT0210","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.395"},{"key":"CIT0211","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24232"},{"key":"CIT0212","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2012.06.001"},{"key":"CIT0213","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.molcel.2006.04.006","volume":"22","author":"Roe JS","year":"2006","journal-title":"Mol Cell"},{"key":"CIT0214","doi-asserted-by":"publisher","DOI":"10.1038\/20459"},{"key":"CIT0215","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209597"},{"key":"CIT0216","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.5.7.3024"},{"key":"CIT0217","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/cam4.112","volume":"2","author":"Ellinghaus P","year":"2013","journal-title":"Cancer Med"},{"key":"CIT0218","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58780"},{"key":"CIT0219","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.001"},{"key":"CIT0220","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9024293"},{"key":"CIT0221","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.736979"},{"key":"CIT0222","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600936"},{"key":"CIT0223","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3554"},{"key":"CIT0224","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.10.043"},{"key":"CIT0225","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.04.018"},{"key":"CIT0226","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.06.019"},{"key":"CIT0227","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.06.022"},{"key":"CIT0228","doi-asserted-by":"publisher","DOI":"10.1021\/cb1003477"},{"key":"CIT0229","doi-asserted-by":"publisher","DOI":"10.1021\/jm300529u"},{"key":"CIT0230","doi-asserted-by":"publisher","DOI":"10.1021\/jm4009532"},{"key":"CIT0231","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.06.018"},{"key":"CIT0232","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(97)00220-X"},{"key":"CIT0233","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2820"},{"key":"CIT0234","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3579"},{"key":"CIT0235","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2470"},{"key":"CIT0236","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.455"},{"key":"CIT0237","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1470-6"},{"key":"CIT0238","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2012.00199"},{"key":"CIT0239","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2034"},{"key":"CIT0240","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106123108"},{"key":"CIT0241","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio744"},{"key":"CIT0242","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2270"},{"key":"CIT0243","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/ijc.26125","volume":"130","author":"Chiche J","year":"2012","journal-title":"Int J Cancer"},{"key":"CIT0244","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-0767"},{"key":"CIT0245","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130008"},{"key":"CIT0246","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1795"},{"key":"CIT0247","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.05.006"},{"key":"CIT0248","doi-asserted-by":"publisher","DOI":"10.3109\/14756369909030328"},{"key":"CIT0249","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.04.005"},{"key":"CIT0250","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.07.087"},{"key":"CIT0251","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.04.056"},{"key":"CIT0252","doi-asserted-by":"publisher","DOI":"10.1021\/jm101541x"},{"key":"CIT0253","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc02707c"},{"key":"CIT0254","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.422"},{"key":"CIT0255","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc16395k"},{"key":"CIT0256","doi-asserted-by":"publisher","DOI":"10.1021\/jm300031j"},{"key":"CIT0257","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.641015"},{"key":"CIT0258","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.12.033"},{"key":"CIT0259","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mrrev.2012.08.001","volume":"752","author":"Kramer N","year":"2013","journal-title":"Mutat Res"},{"key":"CIT0260","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3001"},{"key":"CIT0261","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-0905"},{"key":"CIT0262","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047995"},{"key":"CIT0263","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.040554897"},{"key":"CIT0264","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.09.062"},{"key":"CIT0265","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.05.083"},{"key":"CIT0266","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2008.03.006"},{"key":"CIT0267","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-08-0251"},{"key":"CIT0268","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909228106"},{"key":"CIT0269","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.150"},{"key":"CIT0270","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208324109"},{"key":"CIT0271","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ccr.2004.08.034","volume":"6","author":"Cao R","year":"2004","journal-title":"Cancer Cell"},{"key":"CIT0272","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.359"},{"key":"CIT0273","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2938"},{"key":"CIT0274","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-8-61"},{"key":"CIT0275","first-page":"36","volume":"231","author":"Meehan J WC","year":"2013","journal-title":"J Pathol"},{"key":"CIT0276","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.11.004"},{"key":"CIT0277","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1158\/0008-5472.CAN-08-4210","volume":"69","author":"Daniel VC","year":"2009","journal-title":"Cancer Res"},{"key":"CIT0278","first-page":"133","volume":"88","author":"Langdon SP","year":"2004","journal-title":"Method Mol Med"},{"key":"CIT0279","doi-asserted-by":"publisher","DOI":"10.1038\/nature09807"},{"key":"CIT0280","first-page":"4373","volume":"49","author":"Tannock IF","year":"1989","journal-title":"Cancer Res"},{"key":"CIT0281","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0620-8_4"},{"key":"CIT0282","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1695"},{"key":"CIT0283","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2008.03.013"},{"key":"CIT0284","doi-asserted-by":"crossref","first-page":"18708","DOI":"10.1073\/pnas.1111840108","volume":"108","author":"Gillet JP","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"CIT0285","first-page":"1295","volume":"27","author":"Mehta JP","year":"2007","journal-title":"Anticancer Res"},{"key":"CIT0286","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014594825502"},{"key":"CIT0287","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.006"},{"key":"CIT0288","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2236"},{"key":"CIT0289","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00503"},{"key":"CIT0290","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-008-2245-2"},{"key":"CIT0291","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1858"},{"key":"CIT0292","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2010.01.012"},{"key":"CIT0293","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200700228"},{"key":"CIT0294","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-6-11"},{"key":"CIT0295","doi-asserted-by":"publisher","DOI":"10.1038\/ng1060"},{"key":"CIT0296","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/09553000701727531","volume":"83","author":"Friedrich J","year":"2007","journal-title":"Int J Radiat Biol"},{"key":"CIT0297","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1893"},{"key":"CIT0298","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.006478"},{"key":"CIT0299","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1877"},{"key":"CIT0300","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrd1635","volume":"4","author":"Kamb A","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"CIT0301","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.240"},{"key":"CIT0302","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2193"},{"key":"CIT0303","doi-asserted-by":"publisher","DOI":"10.4161\/cc.21195"},{"key":"CIT0304","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3627"},{"key":"CIT0305","doi-asserted-by":"publisher","DOI":"10.1593\/neo.121038"},{"key":"CIT0306","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1200\/JCO.2010.30.8304","volume":"29","author":"Politi K","year":"2011","journal-title":"J Clin Oncol"},{"key":"CIT0307","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2110"},{"key":"CIT0308","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171362"},{"key":"CIT0309","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1158\/1078-0432.CCR-10-1206","volume":"16","author":"Graves EE","year":"2010","journal-title":"Clin Cancer Res"},{"key":"CIT0310","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2004"},{"key":"CIT0311","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1640"},{"key":"CIT0312","doi-asserted-by":"publisher","DOI":"10.1038\/nature10937"},{"key":"CIT0313","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4003"},{"key":"CIT0314","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1745"},{"key":"CIT0315","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3573"},{"key":"CIT0316","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2454"},{"key":"CIT0317","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0610"},{"key":"CIT0318","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos061"},{"key":"CIT0319","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/bcr3095","volume":"14","author":"Reyal F","year":"2012","journal-title":"Breast Cancer Res"},{"key":"CIT0320","doi-asserted-by":"publisher","DOI":"10.1038\/nature08989"},{"key":"CIT0321","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-1069"},{"key":"CIT0322","doi-asserted-by":"crossref","first-page":"608","DOI":"10.18632\/oncotarget.520","volume":"3","author":"Katz E","year":"2012","journal-title":"Oncotarget"},{"key":"CIT0323","first-page":"24","volume":"231","author":"Ward C MJ","year":"2013","journal-title":"J Pathol"},{"key":"CIT0324","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-86"},{"key":"CIT0325","doi-asserted-by":"publisher","DOI":"10.1038\/nm1469"},{"key":"CIT0326","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10156"},{"key":"CIT0327","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.61"},{"key":"CIT0328","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2286"},{"key":"CIT0329","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0061"},{"key":"CIT0330","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2010.07.001"},{"key":"CIT0331","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.11.061"},{"key":"CIT0332","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2012.04.003"},{"key":"CIT0333","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.09.015"},{"key":"CIT0334","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.815797"},{"key":"CIT0335","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102526108"},{"key":"CIT0336","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1437-x"},{"key":"CIT0337","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1097\/MNM.0b013e3283407950","volume":"31","author":"Doss M","year":"2010","journal-title":"Nucl Med Commun"},{"key":"CIT0338","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.08.031"},{"key":"CIT0339","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.171"},{"key":"CIT0340","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.07.028"},{"key":"CIT0341","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3322"},{"key":"CIT0342","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605450"},{"key":"CIT0343","doi-asserted-by":"publisher","DOI":"10.1038\/nature10983"},{"key":"CIT0344","doi-asserted-by":"publisher","DOI":"10.1038\/nature11412"},{"key":"CIT0345","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00944.x"},{"key":"CIT0346","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0542"},{"key":"CIT0347","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1704"},{"key":"CIT0348","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1158\/1078-0432.CCR-07-1755","volume":"14","author":"Camps C","year":"2008","journal-title":"Clin Cancer Res"},{"key":"CIT0349","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.56"},{"key":"CIT0350","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.08.015"},{"key":"CIT0351","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010345"},{"key":"CIT0352","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-0489"},{"key":"CIT0353","doi-asserted-by":"crossref","first-page":"e20980","DOI":"10.1371\/journal.pone.0020980","volume":"6","author":"Rothe F","year":"2011","journal-title":"PLoS One"},{"key":"CIT0354","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1085"},{"key":"CIT0355","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2711"},{"key":"CIT0356","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.07.023"},{"key":"CIT0357","first-page":"2416","volume":"9","author":"Mabjeesh NJ","year":"2003","journal-title":"Clin Cancer Res"},{"key":"CIT0358","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-06-0226"},{"key":"CIT0359","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70292-8"},{"key":"CIT0360","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.2878"},{"key":"CIT0361","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1182"},{"key":"CIT0362","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.09.010"},{"key":"CIT0363","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.06.011"},{"key":"CIT0364","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.818247"},{"key":"CIT0365","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2540"},{"key":"CIT0366","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.121"},{"key":"CIT0367","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.164"},{"key":"CIT0368","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.04.036"},{"key":"CIT0369","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-011-9231-3"},{"key":"CIT0370","doi-asserted-by":"crossref","first-page":"e50806","DOI":"10.1371\/journal.pone.0050806","volume":"7","author":"Ree AH","year":"2012","journal-title":"PLoS One"},{"key":"CIT0371","doi-asserted-by":"crossref","first-page":"e63723","DOI":"10.1371\/journal.pone.0063723","volume":"8","author":"Roe K","year":"2013","journal-title":"PLoS One"},{"key":"CIT0372","doi-asserted-by":"crossref","first-page":"e72692","DOI":"10.1371\/journal.pone.0072692","volume":"8","author":"Tahiri A","year":"2013","journal-title":"PLoS One"},{"key":"CIT0373","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.12.003"},{"key":"CIT0374","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.09.008"},{"key":"CIT0375","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.07.026"},{"key":"CIT0376","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-6-80"},{"key":"CIT0377","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2011.43.2.75"},{"key":"CIT0378","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31824166a5"},{"key":"CIT0379","doi-asserted-by":"crossref","first-page":"e385","DOI":"10.1016\/j.ijrobp.2012.04.045","volume":"84","author":"Higginson DS","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"CIT0380","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2009.10.018"},{"key":"CIT0381","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.08.036"},{"key":"CIT0382","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70510-7"},{"key":"CIT0383","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318262caf6"},{"key":"CIT0384","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrclinonc.2011.83","volume":"8","author":"De Bock K","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"CIT0385","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2537"},{"key":"CIT0386","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ccr.2011.11.024","volume":"21","author":"Cooke VG","year":"2012","journal-title":"Cancer Cell"},{"key":"CIT0387","first-page":"CD004078","volume":"3","author":"Petersen SH","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"CIT0388","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70599-0"},{"key":"CIT0389","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2008.04.001"},{"key":"CIT0390","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nrd3025","volume":"8","author":"Orloff J","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"CIT0391","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.40.1919"},{"key":"CIT0392","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.07.007"},{"key":"CIT0393","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20135"},{"key":"CIT0394","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113205"},{"key":"CIT0395","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0357"},{"key":"CIT0396","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.06.015"},{"key":"CIT0397","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980615)82:12<2418::AID-CNCR16>3.0.CO;2-S"},{"key":"CIT0398","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.196"},{"key":"#cr-split#-CIT0399.1","doi-asserted-by":"crossref","unstructured":"(a) Supuran CT. Inhibition of carbonic anhydrase IX as a novel anticancer mechanism. World J Clin Oncol 2012;3:98-103.","DOI":"10.5306\/wjco.v3.i7.98"},{"key":"#cr-split#-CIT0399.2","doi-asserted-by":"crossref","unstructured":"(b) Supuran CT. Structure-based drug discovery of carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem 2012;27;759-72","DOI":"10.3109\/14756366.2012.672983"},{"key":"CIT0400","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2013.761876"}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/14756366.2014.966704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T15:42:15Z","timestamp":1746459735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.3109\/14756366.2014.966704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,27]]},"references-count":401,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9,3]]}},"alternative-id":["10.3109\/14756366.2014.966704"],"URL":"https:\/\/doi.org\/10.3109\/14756366.2014.966704","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"value":"1475-6366","type":"print"},{"value":"1475-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,27]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2014-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}