{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T07:15:50Z","timestamp":1776064550211,"version":"3.50.1"},"reference-count":43,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrial DNA Part A"],"published-print":{"date-parts":[[2017,5,4]]},"DOI":"10.3109\/19401736.2015.1136304","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T12:43:51Z","timestamp":1453466631000},"page":"434-441","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":9,"title":["Mitochondrial haplogroup D4j specific variant m.11696G\u2009&gt;\u2009a(\n            <i>MT-ND4<\/i>\n            ) may increase the penetrance and expressivity of the LHON-associated m.11778G\u2009&gt;\u2009a mutation in Chinese pedigrees"],"prefix":"10.3109","volume":"28","author":[{"given":"Shipeng","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Xingtai Eye Hospital, Xingtai, Hebei, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China;"},{"name":"School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiji","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minglian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Xingtai Eye Hospital, Xingtai, Hebei, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China;"},{"name":"Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical University, Wenzhou, Zhejiang, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Ping","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dongfang Hospital, Beijing University of Chinese Medicine and Pharmacology, Beijing, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangtian","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China;"},{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchun","family":"Ji","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Xin","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Xingtai Eye Hospital, Xingtai, Hebei, China;"},{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China;"},{"name":"Division of Pathology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2016,1,22]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/13779"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90300-7"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/515488"},{"key":"e_1_3_2_5_1","first-page":"134","article-title":"Spectrum of mitochondrial DNA mutations in Leber's hereditary optic neuropathy.","volume":"2","author":"Brown MD","year":"1994","unstructured":"Brown MD, Wallace DC. (1994). Spectrum of mitochondrial DNA mutations in Leber's hereditary optic neuropathy. Clin Neurosci 2:134\u201345.","journal-title":"Clin Neurosci"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1673-8527(08)60086-7"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.02.024"},{"key":"e_1_3_2_8_1","first-page":"703","article-title":"Genetic and biochemical impairment of mitochondrial complex I activity in a family with Leber hereditary optic neuropathy and hereditary spastic dystonia.","volume":"58","author":"De Vries DD","year":"1996","unstructured":"De Vries DD, Went LN, Bruyn GW, Scholte HR, Hofstra RM, Bolhuis PA, van Oost BA. (1996). Genetic and biochemical impairment of mitochondrial complex I activity in a family with Leber hereditary optic neuropathy and hereditary spastic dystonia. Am J Hum Genet 58:703\u201311.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02602930"},{"key":"e_1_3_2_10_1","first-page":"77","article-title":"Pedigree analysis in Leber hereditary optic neuropathy families with a pathogenic mtDNA mutation.","volume":"57","author":"Harding AE","year":"1995","unstructured":"Harding AE, Sweeney MG, Govan GG, Riordan-Eva P. (1995). Pedigree analysis in Leber hereditary optic neuropathy families with a pathogenic mtDNA mutation. Am J Hum Genet 57:77\u201386.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000072041"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/519394"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.11.002"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-006-0032-2"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16158"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl130"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2006.02.014"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.08.034"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0123s44"},{"key":"e_1_3_2_20_1","first-page":"481","article-title":"Primary pathogenic mtDNA mutations in multigeneration pedigrees with Leber hereditary optic neuropathy.","volume":"59","author":"Mackey DA","year":"1996","unstructured":"Mackey DA, Oostra RJ, Rosenberg T, Nikoskelainen E, Bronte-Stewart J, Poulton J, Harding AE, et\u00a0al. (1996). Primary pathogenic mtDNA mutations in multigeneration pedigrees with Leber hereditary optic neuropathy. Am J Hum Genet 59:481\u20135.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76784-4"},{"key":"e_1_3_2_22_1","first-page":"115","article-title":"Clinical pictures of LHON.","volume":"2","author":"Nikoskelainen EK.","year":"1994","unstructured":"Nikoskelainen EK. (1994). Clinical pictures of LHON. Clin Neurosci 2:115\u201320.","journal-title":"Clin Neurosci"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30665-9"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-010-0821-8"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.05.003"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0665"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2006.11.015"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5027"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.10.022"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.01.062"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.4.967"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.2.319"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)39303-1"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(03)00240-2"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2286304"},{"key":"e_1_3_2_36_1","first-page":"1107","article-title":"Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484.","volume":"60","author":"Torroni A","year":"1997","unstructured":"Torroni A, Petrozzi M, D'Urbano L, Sellitto D, Zeviani M, Carrara F, Carducci C, et\u00a0al. (1997). Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484. Am J Hum Genet 60:1107\u201321.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201231"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.227202. Article published online before print in May 2002"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15311"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.054270"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.07.135"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2010.07.014"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.11.150"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2010.04.013"}],"container-title":["Mitochondrial DNA Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.3109\/19401736.2015.1136304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T12:38:48Z","timestamp":1716295128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.3109\/19401736.2015.1136304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,22]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5,4]]}},"alternative-id":["10.3109\/19401736.2015.1136304"],"URL":"https:\/\/doi.org\/10.3109\/19401736.2015.1136304","relation":{},"ISSN":["2470-1394","2470-1408"],"issn-type":[{"value":"2470-1394","type":"print"},{"value":"2470-1408","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,22]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=imdn21","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=imdn21","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2015-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}