{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:31:29Z","timestamp":1769574689471,"version":"3.49.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foot Ankle Int."],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p> Background: Diabetic patients with Charcot arthropathy of the foot are at high risk for nonunion when undergoing arthrodesis. There is increasing evidence that cytokines identified in platelet rich concentrate and bone marrow aspirate may show equivalence to autologous bone graft in supporting arthrodesis. Materials and Methods: Prospectively, 44 high-risk diabetic patients with Charcot foot arthropathy underwent surgical correction of 46 feet through a limited surgical approach. The average age of the patients was 54.9 \u00b1 10.4 years. Their mean BMI was 38.0 \u00b1 9.7. Twenty-four were male and 20 were female. Twenty-eight had open wounds with chronic draining osteomyelitis. Surgical correction was maintained postoperatively with static circular ring fixation. At the time of wound closure, all of the patients had injection of autologous platelet rich concentrate and bone marrow aspirate. Results: Forty-two of the 46 feet had radiographic evidence of bony union at 26.2 \u00b1 12.2 months following surgery. One patient died of unrelated causes. Two underwent amputation for persistent infection. Six had recurrent ulcers which resolved with local treatment. One patient required a fifth ray resection for gangrene following surgery. There were three tibial stress fractures, with two requiring intramedullary nailing to achieve union. Conclusions: Platelet-rich concentrate, when combined with a small amount of autologous bone marrow aspirate, may well be as effective as autologous bone grafting when performing arthrodesis of high risk diabetic patients with Charcot foot arthropathy. <\/jats:p>","DOI":"10.3113\/fai-2009-0124","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T18:59:28Z","timestamp":1449255568000},"page":"124-127","source":"Crossref","is-referenced-by-count":29,"title":["Use of Platelet-Rich Concentrate and Bone Marrow Aspirate in High-Risk Patients with Charcot Arthropathy of the Foot"],"prefix":"10.1177","volume":"30","author":[{"given":"Michael S.","family":"Pinzur","sequence":"first","affiliation":[{"name":"Maywood, IL"},{"name":"No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. Some of the patiets in this investigation were included in a surgical technique paper noted in reference #19."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,2,1]]},"reference":[{"key":"bibr1-10.3113_FAI-2009-0124","first-page":"455","volume":"4","author":"Andrew JG","year":"1995","journal-title":"Bone"},{"key":"bibr2-10.3113_FAI-2009-0124","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00066-9"},{"key":"bibr3-10.3113_FAI-2009-0124","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2008.0568"},{"key":"bibr4-10.3113_FAI-2009-0124","first-page":"1","volume":"14","author":"Bibbo C","year":"2005","journal-title":"Journal of Surgical Orthopaedic Advances."},{"key":"bibr5-10.3113_FAI-2009-0124","doi-asserted-by":"publisher","DOI":"10.1038\/nm848"},{"key":"bibr6-10.3113_FAI-2009-0124","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200803000-00007"},{"key":"bibr7-10.3113_FAI-2009-0124","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200711000-00011"},{"key":"bibr8-10.3113_FAI-2009-0124","unstructured":"8. Gandhi A, Gebauer G, Berberian W, Lin SS: Reduction in Growth Factors in the Fracture Hematoma of Diabetic Patients. Paper presented at the Annual Meeting of the Orthopaedic Research Society, New Orleans. Feb 10-13, 2003."},{"key":"bibr9-10.3113_FAI-2009-0124","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcl.2006.06.009"},{"key":"bibr10-10.3113_FAI-2009-0124","unstructured":"10. Gandhi A, Van Gelderen J, Berberian WS. Platelet Releasate Enhances Healing in Patients with a nonunion. Paper presented at the Annual Meeting of the Orthopaedic Research Society. New Orleans, February 10-13, 2003."},{"key":"bibr11-10.3113_FAI-2009-0124","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112243"},{"key":"bibr12-10.3113_FAI-2009-0124","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.01231"},{"key":"bibr13-10.3113_FAI-2009-0124","first-page":"391","volume":"365","author":"Joyce ME","year":"1991","journal-title":"Prog Clin Biol Res."},{"key":"bibr14-10.3113_FAI-2009-0124","unstructured":"14. Koener J, Lin SS, Pinzur MS: The Role of PDGF AND VEGF in Promoting Arthrodesis of the Foot and Ankle in Patients with Charcot Foot Arthropathy. 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