{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:00:19Z","timestamp":1787025619289,"version":"build-2736575974"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foot Ankle Int."],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    Chondral damage from the impact of injury may contribute to the high incidence of post-traumatic arthritis after calcaneal fractures, but this has yet to be proven. We sought to study the effect of intra-articular calcaneal fractures on chondrocyte viability and to correlate these effects with injury severity, time from injury to surgery, and patient age and co-morbidities.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    Irreducible osteochondral fragments from 12 patients undergoing operative treatment for intra-articular calcaneal fractures were analyzed. Control cartilage was obtained from four tissue donors who died of unrelated causes. The cartilage was assessed for chondrocyte viability through the full thickness of tissue using a Live\/Dead assay followed by laser scanning confocal microscopy. Patient demographics including injury classification and severity, time from injury to surgery, and patient age were recorded.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    Chondrocyte viability from fracture patients averaged 72.8% \u00b1 12.9% (range 53% to 95%), which was significantly lower than the 94.8% \u00b1 1.5% viability observed in the control specimens (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.005). Chondrocyte viability declined with higher energy injuries (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.13), time from injury to surgery (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.07), and increasing patient age (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.07). However, none of these factors reached a level of statistical significance.\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    A significant decline in chondrocyte viability occurs after intra-articular fractures of the calcaneus. This may contribute to the development of post-traumatic arthritis.\n                  <\/jats:p>","DOI":"10.3113\/fai.2007.0665","type":"journal-article","created":{"date-parts":[[2007,6,25]],"date-time":"2007-06-25T21:41:17Z","timestamp":1182807677000},"page":"665-668","source":"Crossref","is-referenced-by-count":47,"title":["Chondrocyte Viability After Intra-articular Calcaneal Fractures in Humans"],"prefix":"10.1177","volume":"28","author":[{"given":"Scott T.","family":"Ball","sequence":"first","affiliation":[{"name":"San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Jadin","sequence":"additional","affiliation":[{"name":"San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Todd","family":"Allen","sequence":"additional","affiliation":[{"name":"San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra K.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Sah","sequence":"additional","affiliation":[{"name":"San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Brage","sequence":"additional","affiliation":[{"name":"San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,6]]},"reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200401000-00043"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000131638.81519.de"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000131233.83640.91"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199509040-00001"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0828"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0006355X2004041003004017"},{"key":"e_1_3_1_8_1","first-page":"1","article-title":"Roles of articular cartilage aging and chondrocyte senescence in the pathogenesis of osteoarthritis","volume":"21","author":"Martin JA","year":"2001","unstructured":"7 Martin JA, Buckwalter JA: Roles of articular cartilage aging and chondrocyte senescence in the pathogenesis of osteoarthritis. Iowa Orthop. J. 21:1\u20137, 2001.","journal-title":"Iowa Orthop. J."},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100150403"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000051934.96670.37"},{"key":"e_1_3_1_11_1","first-page":"87","article-title":"Operative treatment in 120 displaced intraarticular calcaneal fractures","volume":"290","author":"Sanders R","year":"1993","unstructured":"10 Sanders R, Fortin P, DiPasquale T, Walling A: Operative treatment in 120 displaced intraarticular calcaneal fractures. Results using a prognostic computed tomography scan classification. Clin. Orthop. 290:87\u201395, 1993.","journal-title":"Results using a prognostic computed tomography scan classification. Clin. Orthop."},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070402501007"},{"key":"e_1_3_1_13_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.72B4.2380219"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016470410004148"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200311000-00008"}],"container-title":["Foot &amp; Ankle International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3113\/FAI.2007.0665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3113\/FAI.2007.0665","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3113\/FAI.2007.0665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:07:19Z","timestamp":1767679639000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3113\/FAI.2007.0665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.3113\/FAI.2007.0665"],"URL":"https:\/\/doi.org\/10.3113\/fai.2007.0665","relation":{},"ISSN":["1071-1007","1944-7876"],"issn-type":[{"value":"1071-1007","type":"print"},{"value":"1944-7876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}