{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:40:27Z","timestamp":1787240427881,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foot Ankle Int."],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>\n                    Background: The potential benefit of hyaluronans in alleviating pain associated with osteoarthritis (OA) in joints other than the knee is of increasing interest. This double-blind, randomized, controlled study examined the safety and efficacy of intra-articular sodium hyaluronate (Hyalgan\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ) in the treatment of pain associated with ankle OA. Materials and Methods: Thirty consecutive patients with ankle OA documented by X-ray were randomized to treatment with five weekly injections of either sodium hyaluronate 2 mL (HYL) or phosphate-buffered saline 2 mL (control) in the tibiotalar joint. The primary endpoint was pain on movement and weightbearing using the Ankle Osteoarthritis Scale (AOS) 3 months after injection (a 100-mm visual analog scale [VAS]). Additional measures included the Western Ontario and McMaster Universities (WOMAC) OA Index and patient global assessment through 6 months; the Short Form-12 (SF-12) Health Survey at 3 months and 6 months; and all reported adverse events (AEs). Results: The study groups differed only in age, baseline WOMAC pain, and AOS total scores; 80% of the HYL and 73% of the control patients completed the study. At Month 3, the primary endpoint of the study, the HYL group demonstrated a significantly greater improvement from baseline in AOS total score than did the control group (HYL: \u221217.4 \u00b1 5.0 mm; Control: \u22125.1 \u00b1 4.0 mm; p = 0.0407). The incidence of AEs was low, with no significant differences between the groups. There were no post-injection flares. Conclusion: Our study suggests that sodium hyaluronate may be a safe and effective option for pain associated with ankle OA, although larger studies are needed.\n                  <\/jats:p>","DOI":"10.3113\/fai.2008.0657","type":"journal-article","created":{"date-parts":[[2008,7,22]],"date-time":"2008-07-22T15:42:50Z","timestamp":1216741370000},"page":"657-663","source":"Crossref","is-referenced-by-count":86,"title":["Safety and Efficacy of Intra-articular Sodium Hyaluronate (Hyalgan\n                    <sup>\u00ae<\/sup>\n                    ) in a Randomized, Double-Blind Study for Osteoarthritis of the Ankle"],"prefix":"10.1177","volume":"29","author":[{"given":"Michael M.","family":"Cohen","sequence":"first","affiliation":[{"name":"Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy D.","family":"Altman","sequence":"additional","affiliation":[{"name":"Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hollstrom","sequence":"additional","affiliation":[{"name":"Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hollstrom","sequence":"additional","affiliation":[{"name":"Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Sun","sequence":"additional","affiliation":[{"name":"Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Gipson","sequence":"additional","affiliation":[{"name":"Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"bibr1-FAI.2008.0657","first-page":"9","volume":"15","author":"Abatangelo G","year":"1995","journal-title":"Eur. 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