{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:23:23Z","timestamp":1792697003983,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foot Ankle Int."],"published-print":{"date-parts":[[2009,9]]},"abstract":"\n Background:<\/jats:title>\n Articular cartilage is limited in its ability to repair itself. Matrix-induced Autologous Chondrocyte Implantation (MACI) is an established treatment method for such articular cartilage defects in the knee. Recently the technique has been used in the ankle. We present a series of patients treated with MACI for osteochondral defects of the ankle, and assess the functional and clinical results.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n From August 2003 to February 2006, 20 patients underwent MACI grafting for osteochondral defects in the ankle. Age ranged from 19 to 61 (mean, 36) years. Mean followup was 21.1 months. Clinical and functional evaluations were conducted using the AOFAS scoring system.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean size was 233 mm\n 2<\/jats:sup>\n . There was a significant improvement in mean AOFAS score from 60 (range, 25 to 87) to 87 (range, 41 to 100) (\n p<\/jats:italic>\n < 0.0001). Overall improvement in pain scores was also significant (\n p<\/jats:italic>\n < 0.0001). All osteotomies healed. Four patients required hardware removal and two underwent arthroscopic debridement for anterior impingement. There were two failures which are awaiting subsequent procedures.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n We believe MACI is a reliable treatment method for talar osteochondral defects. The method usually requires an intra-articular osteotomy, although this proved to be a reasonably simple aspect of the procedure for the treatment of cartilage defects of the talus.<\/jats:p>\n Level of Evidence: IV, Case Series<\/jats:p>\n <\/jats:sec>","DOI":"10.3113\/fai.2009.0810","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T12:25:48Z","timestamp":1253017548000},"page":"810-814","source":"Crossref","is-referenced-by-count":96,"title":["Matrix-Induced Autologous Chondrocyte Implantation (MACI) Grafting for Osteochondral Lesions of the Talus"],"prefix":"10.1177","volume":"30","author":[{"given":"Timothy E.","family":"Schneider","sequence":"first","affiliation":[{"name":"Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Karaikudi","sequence":"additional","affiliation":[{"name":"Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,9]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070202300502"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-8063(86)80017-2"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-7515(03)00016-0"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B5.15905"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.69B1.3818743"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(96)00117-2"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200005000-00005"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-196603000-00007"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/230949900301100104"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-197508000-00011"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5919(20)30618-9"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198971010-00005"},{"issue":"10","key":"e_1_3_2_14_1","first-page":"628","article-title":"Treatment of osteochondritis disseuse of the mosaicplasty technique\u2014Acans of the Ttalus","volume":"18","author":"Hangody L","year":"1997","unstructured":"13 Hangody L, Kish G, Krp\u00e1ti Z, Szerb I, Eberhardt R: Treatment of osteochondritis disseuse of the mosaicplasty technique\u2014Acans of the Ttalus. U\u00e1a Int. 18(10): 628\u2013634, 1997. preliminary report. Foot Ankle.","journal-title":"U\u00e1a Int."},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070102200704"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110079401500701"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200202000-00021"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199909000-00004"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070302401102"},{"key":"e_1_3_2_20_1","volume-title":"Statistical Methods for Anaesthesia and Intensive Care","author":"Myles P","year":"2000","unstructured":"19 Myles P, Gin T: Statistical Methods for Anaesthesia and Intensive Care. First Edition, Butterworth Heinemann Oxford, 2000."},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.85B7.13959"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199603000-00018"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110079902000802"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/036354658401200611"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070002100205"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B2.15376"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0218957703001125"},{"issue":"5","key":"e_1_3_2_28_1","first-page":"623","article-title":"Molecular characterisation of chondrocytes in autologous chondrocyte implantation","volume":"13","author":"Zheng MH","year":"2004","unstructured":"27 Zheng MH, King E, Kirilak Y, : Molecular characterisation of chondrocytes in autologous chondrocyte implantation. 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