{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T21:56:37Z","timestamp":1726437397289},"reference-count":0,"publisher":"Nepal Journals Online (JOL)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kathmandu Univ. Med. J."],"abstract":"<jats:p>Background: Vernal keratoconjunctivitis (VKC) is recurrent chronic allergic conjunctivitis occurring in the prepubertal age-group with secondary involvement of the cornea and is self-limiting in character. The disease is prevalent worldwide but it shows predominance in the areas with dry and warm climate including the South Asia. VKC represents about 3% of the serious ophthalmic disease in some parts of the world where the prevalence is rate is high.Type I hypersensitivity reaction which is IgE-dependent and type IV hypersensitivity reaction have been implicated for the pathogenesis VKC.  Objective: To determine level of immunoglobulin E (IgE) in the tear film of patients with Vernal Keratoconjunctivitis (VKC) attending outpatient department of BP Koirala Lions Centre for Ophthalmic Studies (BPKLCOS).  Materials and methods: Thirty-four VKC patients and thirty-four controls were included in this study. Tear samples were collected using micro- capillary glass tube method and tear IgE levels were measured using an enzyme - linked immunosorbent assay (ELISA).  Results: There was high concentration of tear IgE level in VKC (95.09IU\/ml) than in controls (1.63IU\/ml) though the difference was not statistically significant (p=0.16). No statistically significant difference was observed in male and female gender within VKC group and when compared with control group (in male group, p=0.21 and in female group, p=0.26). There was no statistically significant difference observed in tear IgE level in different age groups within VKC group and when compared with control group (p=0.30). The result did not show any significant difference in tear IgE level with respect to the duration of the disease (p=0.23).There was no statistically significant difference in tear IgE level with different episodes of VKC (p=0.69). No statistically significant difference of IgE concentration in tear was seen among different types of VKC (p=0.53) and grades of tarsal and limbal papillae (p= 0.72).  Conclusion: There was high concentration of tear IgE level observed in VKC. Key words: Vernal keratoconjunctivitis; Tearfilm; IgE level; Type I hypersensitivity reaction; Type IV hypersensitivity reaction. DOI: 10.3126\/kumj.v7i2.2700 Kathmandu University Medical Journal (2009) Vol.7, No.2 Issue 26, 104-108<\/jats:p>","DOI":"10.3126\/kumj.v7i2.2700","type":"journal-article","created":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T09:32:27Z","timestamp":1266485547000},"page":"104-108","source":"Crossref","is-referenced-by-count":3,"title":["Tearfilm immunoglobulin E (IgE) level in vernal keratoconjunctivitis by ELISA"],"prefix":"10.3126","volume":"7","author":[{"given":"S","family":"Pokharel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DN","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SN","family":"Joshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Choudhary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1670","published-online":{"date-parts":[[1970,1,1]]},"container-title":["Kathmandu University Medical Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.nepjol.info\/index.php\/KUMJ\/article\/download\/2700\/2393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nepjol.info\/index.php\/KUMJ\/article\/download\/2700\/2393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T20:48:19Z","timestamp":1545770899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nepjol.info\/index.php\/KUMJ\/article\/view\/2700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,1,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,2,18]]}},"URL":"https:\/\/doi.org\/10.3126\/kumj.v7i2.2700","relation":{},"ISSN":["1812-2078","1812-2027"],"issn-type":[{"value":"1812-2078","type":"electronic"},{"value":"1812-2027","type":"print"}],"subject":[],"published":{"date-parts":[[1970,1,1]]}}}