{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:27:17Z","timestamp":1793604437944,"version":"4.5.0"},"reference-count":0,"publisher":"Nepal Journals Online (JOL)","issue":"2","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nep J Oph"],"abstract":"<jats:p>Introduction: Dacryocystorhinostomy (DCR) is the commonest surgery for\u00a0nasolacrimal duct obstruction. Inhibition of the scarring process within the anastomosis\u00a0and rhinostomy site which has been attributed to the failure of this procedure, might\u00a0improve the success rate of DCR. The objective of this study was to evaluate the\u00a0outcomes of DCR with Mitomycin-C (MMC) and to compare the results of DCR with\u00a0and without MMC.\r\nMaterials and methods: A hospital based, prospective study was conducted in patients\u00a0with primary acquired nasolacrimal duct obstruction. Standard conventional DCR was\u00a0performed upto the level of creation of flaps. Application of MMC 0.2 mg\/ml in and\u00a0around the ostium and underneath the created flaps for two minutes was effected with\u00a0cotton pledgets. The area was thoroughly washed with normal saline after removal of\u00a0the pledgets. Rest of the surgery was completed as usual. The patients were followed\u00a0up on the first postoperative day, one month and three months post surgery.\r\nResults: A total of 60 cases, 30 in each group were allocated. The success rate of DCR\u00a0with MMC was found to be 96.7% compared to 86.7% (p=0.35) in the DCR group at\u00a0the end of three months duration.\r\nConclusions: Intraoperative application of MMC during conventional DCR surgery\u00a0provides a comparatively higher success rate than DCR without MMC without posing\u00a0any extra financial burden and adverse drug reaction to the patient.<\/jats:p>","DOI":"10.3126\/nepjoph.v12i2.25655","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T13:59:10Z","timestamp":1601992750000},"page":"209-215","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of Conventional External Dacryocystorhinostomy with and without Mitomycin C: Experience from Eastern Nepal"],"prefix":"10.3126","volume":"12","author":[{"given":"Simanta","family":"Khadka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purushottam","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prava","family":"Subedi Basnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandni","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1670","published-online":{"date-parts":[[2020,10,5]]},"container-title":["Nepalese Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.nepjol.info\/index.php\/NEPJOPH\/article\/download\/25655\/25113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nepjol.info\/index.php\/NEPJOPH\/article\/download\/25655\/25113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T06:48:15Z","timestamp":1793602095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nepjol.info\/index.php\/NEPJOPH\/article\/view\/25655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,5]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,10,6]]}},"URL":"https:\/\/doi.org\/10.3126\/nepjoph.v12i2.25655","relation":{},"ISSN":["2091-0320","2072-6805"],"issn-type":[{"value":"2091-0320","type":"electronic"},{"value":"2072-6805","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,5]]}}}