{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:54:32Z","timestamp":1740160472463,"version":"3.37.3"},"reference-count":0,"publisher":"Nepal Journals Online (JOL)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nep J Oph"],"abstract":"<jats:p>Background: We describe a case o f a recurrent ocular surface squamous neoplasia (OSSN) in a 37-year-old male with a mass at the infero-temporal quadrant along with an isolated primary lesion at the upper nasal quadrant for the last five months with a past history of surgical excision 7 years ago for a nodular mass in the same eye. The mass showed delayed response to Mitomycin C (MMC) therapy and finally developed limbal stem cell deficiency. Case report: A 37-year-old male presented with a five-month history of foreign body sensation and localized conjunctival hyperemia and two progressively enlarging bumps over the limbus in the left eye. The past history stated a surgical excision, done 7 years ago, for a nodular mass in the same eye. A clinical diagnosis of recurrent OSSN was made, and confirmed by impression cytology. The patient received initial treatment with 0.02 % MMC, but did not show any improvement even after 3 cycles, but later showed marked chemoreduction with 0.04 % MMC on two cycles and a complete resolution of the neoplasia after two more cycles. Impression cytology at six months revealed no abnormality. But at the 10-month follow-up, limbal stem cell deficiency was observed. Conclusion: While examining, managing and follow-up of a case of OSSN, one needs to know the atypical nature and response of the tumour. Long-term follow-up in these cases is mandatory.DOI: http:\/\/dx.doi.org\/10.3126\/nepjoph.v3i2.5297 Nepal J Ophthalmol 2011; 3(2): 199-201\u00a0<\/jats:p>","DOI":"10.3126\/nepjoph.v3i2.5297","type":"journal-article","created":{"date-parts":[[2011,8,24]],"date-time":"2011-08-24T04:01:57Z","timestamp":1314158517000},"page":"199-201","source":"Crossref","is-referenced-by-count":0,"title":["Ocular surface squamous neoplasia in a young adult - its nature and unusual course"],"prefix":"10.3126","volume":"3","author":[{"given":"A","family":"Panda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NK","family":"Sasikala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1670","published-online":{"date-parts":[[1970,1,1]]},"container-title":["Nepalese Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.nepjol.info\/index.php\/NEPJOPH\/article\/download\/5297\/4396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nepjol.info\/index.php\/NEPJOPH\/article\/download\/5297\/4396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T12:01:23Z","timestamp":1545998483000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nepjol.info\/index.php\/NEPJOPH\/article\/view\/5297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,1,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,8,18]]}},"URL":"https:\/\/doi.org\/10.3126\/nepjoph.v3i2.5297","relation":{},"ISSN":["2091-0320","2072-6805"],"issn-type":[{"type":"electronic","value":"2091-0320"},{"type":"print","value":"2072-6805"}],"subject":[],"published":{"date-parts":[[1970,1,1]]}}}