{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:13:56Z","timestamp":1782753236946,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Ophthalmology"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.3129\/i06-061","type":"journal-article","created":{"date-parts":[[2007,4,10]],"date-time":"2007-04-10T20:34:55Z","timestamp":1176237295000},"page":"693-698","source":"Crossref","is-referenced-by-count":60,"title":["Topical 2% cyclosporine A in preservative-free artificial tears for the treatment of vernal keratoconjunctivitis"],"prefix":"10.1016","volume":"41","author":[{"given":"Adil","family":"Kili\u00e7","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"G\u00fcrler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3129\/i06-061_bib1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/eye.2001.10","article-title":"Topical cyclosporine A in the management of vernal conjunctivitis","volume":"15","author":"Gupta","year":"2001","journal-title":"Eye"},{"key":"10.3129\/i06-061_bib2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S1081-1206(10)61958-8","article-title":"Efficacy and safety of cyclosporine eyedrops in vernal keratoconjunctivitis","volume":"89","author":"Pucci","year":"2002","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.3129\/i06-061_bib3","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/S0161-6420(91)32069-4","article-title":"Topical cyclosporine in vernal keratoconjunctivitis","volume":"98","author":"Bleik","year":"1991","journal-title":"Ophthalmology"},{"key":"10.3129\/i06-061_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1600-0420.1999.tb01165.x","article-title":"Vernal keratoconjunctivitis","volume":"228","author":"Collum","year":"1999","journal-title":"Acta Ophthalmol Scand"},{"key":"10.3129\/i06-061_bib5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/sj.eye.6700675","article-title":"Vernal keratoconjunctivitis","volume":"18","author":"Bonini","year":"2004","journal-title":"Eye"},{"key":"10.3129\/i06-061_bib6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.ophtha.2003.05.035","article-title":"A Randomized trial of topical cyclosporine 0.05% in topical steroid-resistant atopic keratoconjunctivitis","volume":"111","author":"Akpek","year":"2004","journal-title":"Ophthalmology"},{"key":"10.3129\/i06-061_bib7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/09273949409057069","article-title":"Atopic keratoconjunctivitis","volume":"2","author":"Akova","year":"1994","journal-title":"Ocul Immunol Inflamm"},{"key":"10.3129\/i06-061_bib8","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4049\/jimmunol.146.4.1169","article-title":"Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis","volume":"146","author":"Maggi","year":"1991","journal-title":"J Immunol"},{"key":"10.3129\/i06-061_bib9","first-page":"3036","article-title":"Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry","volume":"40","author":"Leonardi","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.3129\/i06-061_bib10","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0091-6749(98)70310-0","article-title":"A flow cytometric study about the immunopathology of vernal keratoconjunctivitis","volume":"101","author":"Avunduk","year":"1998","journal-title":"J Allerg Clin Immunol"},{"key":"10.3129\/i06-061_bib11","first-page":"296","article-title":"Ig E and non-Ig E mechanisms in ocular allergy","volume":"71","author":"Bonini","year":"1993","journal-title":"Ann Allergy"},{"key":"10.3129\/i06-061_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1600-065X.1991.tb00604.x","article-title":"A role for CD4+ T cell subsets producing a selective pattern of lymphokines in the pathogenesis of human chronic inflammatory and allergic diseases","volume":"123","author":"Peltz","year":"1991","journal-title":"Immunol Rev"},{"key":"10.3129\/i06-061_bib13","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0091-6749(98)70023-5","article-title":"Eosinophil surface antigen expression and cytokine production vary in different ocular allergic diseases","volume":"102","author":"Hingorani","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.3129\/i06-061_bib14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1365-2222.2000.00699.x","article-title":"Tear levels of inter-feron-gamma, interleukin (IL)-2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic keratoconjunctivitis and allergic conjunctivitis","volume":"30","author":"Uchio","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.3129\/i06-061_bib15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1398-9995.1995.tb01209.x","article-title":"Eosinophil cationic protein in tears of normal subjects and patients affected by vernal keratoconjunctivitis","volume":"50","author":"Leonardi","year":"1995","journal-title":"Allergy"},{"key":"10.3129\/i06-061_bib16","first-page":"182","article-title":"Therapeutic use of topical cyclosporine","volume":"25","author":"Kaan","year":"1993","journal-title":"Ann Ophthalmol"},{"key":"10.3129\/i06-061_bib17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0161-6420(97)30223-1","article-title":"Efficacy of lodoxam-ide eye drops on mast cells and eosinophils after allergen challenge in allergic conjunctivitis","volume":"104","author":"Bonini","year":"1997","journal-title":"Ophthalmology"},{"key":"10.3129\/i06-061_bib18","first-page":"632","article-title":"Efficacy and safety of lodoxamide 0.1% versus cromolyn sodium 4% in patients with vernal ker-atoconjunctivitis","volume":"113","author":"Caldwell","year":"1992","journal-title":"Eye"},{"key":"10.3129\/i06-061_bib19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1755-3768.1991.tb02000.x","article-title":"Topical indomethacin for vernal keratoconjunctivitis","volume":"69","author":"Gupta","year":"1991","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.3129\/i06-061_bib20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00417-002-0612-6","article-title":"Preservative-free diclofenac sodium 0.1% for vernal keratoconjunctivitis","volume":"241","author":"D\u2019Angelo","year":"2003","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.3129\/i06-061_bib22","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0002-9394(14)77061-8","article-title":"Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis","volume":"110","author":"Secchi","year":"1990","journal-title":"Am J Ophthalmol"},{"key":"10.3129\/i06-061_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0039-6257(86)90035-4","article-title":"Cyclosporine: immunology, pharmacology and therapeutic uses","volume":"31","author":"Nussenblatt","year":"1986","journal-title":"Surv Ophthalmol"},{"key":"10.3129\/i06-061_bib24","first-page":"2686","article-title":"Topical cyclosporine inhibits mast cell-mediated conjunctivitis","volume":"37","author":"Whitcup","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.3129\/i06-061_bib25","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2165\/00003495-199345060-00007","article-title":"Cyclosporin A: a review of its pharmacodynamic and pharmacokinetic properties, and ther-apeutic use in immunoregulatory disorders","volume":"45","author":"Faulds","year":"1993","journal-title":"Drugs"},{"key":"10.3129\/i06-061_bib26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00003226-199309000-00008","article-title":"Topical cyclosporin A in the treatment of anterior segment inflammatory disease","volume":"12","author":"Holland","year":"1993","journal-title":"Cornea"},{"key":"10.3129\/i06-061_bib27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF02169821","article-title":"Topical treatment of severe corneal ulcers with cyclosporin A","volume":"227","author":"Zierhut","year":"1989","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.3129\/i06-061_bib28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1159\/000268041","article-title":"Topical cyclosporin as an adjunct to topical acyclovir treatment in herpetic stromal keratitis","volume":"29","author":"G\u00fcnd\u00fcz","year":"1997","journal-title":"Ophthalmic Res"},{"key":"10.3129\/i06-061_bib29_1","first-page":"81","article-title":"Topical cyclosporine stimulates neovascularization in resolving sterile rheumatoid central corneal ulcers","volume":"98","author":"Gottsch","year":"2000","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.3129\/i06-061_bib29_2","first-page":"87","article-title":"Topical cyclosporine stimulates neovascularization in resolving sterile rheumatoid central corneal ulcers","volume":"98","author":"Gottsch","year":"2000","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.3129\/i06-061_bib30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF02569059","article-title":"Effect of topical cyclosporine A on Tygeson's superficial punctate keratitis","volume":"93","author":"Del Castillo","year":"1996","journal-title":"Doc Ophthalmol"},{"key":"10.3129\/i06-061_bib31","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0161-6420(99)00176-1","article-title":"Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group","volume":"107","author":"Sall","year":"2000","journal-title":"Ophthalmology"},{"key":"10.3129\/i06-061_bib32","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0002-9394(86)90819-6","article-title":"Cyclosporine eye-drops for the treatment of severe vernal keratoconjunctivitis","volume":"101","author":"Ben Ezra","year":"1986","journal-title":"Am J Ophthalmol"},{"key":"10.3129\/i06-061_bib33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000050876","article-title":"Cyclosporine effects on clinical findings and impression cytology specimens in severe vernal keratoconjunctivitis","volume":"215","author":"Avunduk","year":"2001","journal-title":"Ophthalmologica"},{"key":"10.3129\/i06-061_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/eye.1997.14","article-title":"Topical cyclosporine A 2% in the treatment of vernal kerato-conjunctivitis","volume":"11","author":"Mendicute","year":"1997","journal-title":"Eye"},{"issue":"Suppl 2","key":"10.3129\/i06-061_bib35","first-page":"644","article-title":"Treatment of severe vernal keratoconjunctivitis with cyclosporine A eye drops","volume":"22","author":"Ben Ezra","year":"1988","journal-title":"Transplant Proc"},{"key":"10.3129\/i06-061_bib36","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0161-6420(98)99043-1","article-title":"A randomized, placebo-controlled trial of topical cyclosporine A in steroid-dependent atopic keratoconjunc-tivitis","volume":"105","author":"Hingorani","year":"1998","journal-title":"Ophthalmology"},{"key":"10.3129\/i06-061_bib37","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00003226-199311000-00008","article-title":"Effect of topical cyclosporine A on conjunctival T cells in patients with secondary Sj\u00f6gren's syndrome","volume":"12","author":"Power","year":"1993","journal-title":"Cornea"},{"key":"10.3129\/i06-061_bib38","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/S0161-6420(89)32756-4","article-title":"Topical cycylosporine in high-risk corneal transplants","volume":"96","author":"Belin","year":"1989","journal-title":"Ophthalmology"}],"container-title":["Canadian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418206800815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418206800815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T08:01:10Z","timestamp":1707811270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008418206800815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0008418206800815"],"URL":"https:\/\/doi.org\/10.3129\/i06-061","relation":{},"ISSN":["0008-4182"],"issn-type":[{"value":"0008-4182","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}