{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T06:03:33Z","timestamp":1671689013981},"reference-count":12,"publisher":"Czech Society of Ophthalmology of the CzMA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CSO"],"published-print":{"date-parts":[[2022,12,5]]},"abstract":"<jats:p>In this case report, we describe the case of a\u00a050-year-old woman referred by her general practitioner to a\u00a0pulmonologist in order to investigate persistent fever and elevation of C-reactive protein despite antibiotic treatment following a\u00a0respiratory infection. The patient was examined extensively, during which rheumatology, gastroenterology, nephrology, ophthalmology, laboratory and imaging tests were performed. Due to a\u00a0rapid progression of renal insufficiency with active urinary sediment, the patient was referred for a\u00a0renal biopsy, which confirmed tubulointerstitial nephritis, followed by a\u00a0diagnosis of bilateral anterior uveitis two months later - genetic testing was also conducted, which confirmed the diagnosis of tubulointerstitial nephritis with uveitis syndrome. Steroid treatment brought about a\u00a0gradual reduction of proteinuria and a\u00a0stabilisation of renal function.<\/jats:p>","DOI":"10.31348\/2022\/31","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T18:07:13Z","timestamp":1671646033000},"page":"315-318","source":"Crossref","is-referenced-by-count":0,"title":["Tubulointerstitial Nephritis With Uveitis (Tinu Syndrome). A Case Report"],"prefix":"10.31348","volume":"78","author":[{"given":"Ester","family":"Kura\u0161ov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"Ors\u00e1g","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Klementa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Krej\u010d\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16213","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Regusci A, Lava SAG, Milani GP, Bianchetti MG, Simonetti GD, Vanoni F. Tubulointerstitial nephritis and uveitis syndrome: a systematic review. 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Modified C-reactive protein might be a target autoantigen of TINU syndrome. Clin J Am Soc Nephrol. 2011 Jan;6(1):93-100.","DOI":"10.2215\/cjn.09051209"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Wu Y, Potempa LA, El Kebir D, Filep JG. C-reactive protein and inflammation: conformational changes affect function. Biol Chem. 2015 Nov; 396(11):1181-97.","DOI":"10.1515\/hsz-2015-0149"},{"key":"ref6","unstructured":"Mirchi PT, Bedn\u00e1\u0159ov\u00e1 V, Hru\u0161kov\u00e1 Z. Syndrom TINU \u2013 tubulointerstici\u00e1ln\u00ed nefritida s uveitidou. Postgradu\u00e1ln\u00ed nefrologie. 2022; 20 (1), 29-31."},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Rueda-Rueda T, S\u00e1nchez-Vicente JL, Moruno-Rodr\u00edguez A et al. Tubulointerstitial nephritis and uveitis syndrome (TINU). Treatment with immunosuppressive therapy. Arch Soc Esp Oftalmol (Engl Ed). 2018 Jan;93(1):47-51.","DOI":"10.1016\/j.oftale.2017.09.003"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Clive DM, Vanguri VK. The Syndrome of Tubulointerstitial Nephritis With Uveitis (TINU). Am J Kidney Dis. 2018 Jul;72(1):118-128.","DOI":"10.1053\/j.ajkd.2017.11.013"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Praga M, Gonz\u00e1lez E. Acute interstitial nephritis. Kidney Int. 2010;77(11):956-961.","DOI":"10.1038\/ki.2010.89"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Derakhshan A, Derakhshan D. Acute tubulointerstitial nephritis in two sisters with simultaneous uveitis in one. Saudi J Kidney Dis Transpl. 2021 Mar-Apr;32(2):554-558.","DOI":"10.4103\/1319-2442.335470"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Raissian Y, Nasr SH, Larsen CP, et al. Diagnosis of IgG4-related tubulointerstitial nephritis. 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