{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T11:11:08Z","timestamp":1688814668534},"reference-count":10,"publisher":"Czech Society of Ophthalmology of the CzMA","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CSO"],"published-print":{"date-parts":[[2023,2,20]]},"abstract":"<jats:p>Aim: We present a\u00a0case report of a\u00a0patient with dry form of age-related macular degeneration (AMD) in whom we monitored the effect of rheohemapheresis (RhF) treatment over 6 years.\nMethods: A\u00a067-year-old man was examined in April 2014 at the Department of Ophthalmology at the University Hospital in Hradec Kr\u00e1lov\u00e9 for metamorphopsia and decreased visual acuity of the left eye. The patient received general treatment for hypercholesterolemia with Lipfix 10 mg once a\u00a0day (atorvastatin 10 mg). The cholesterol level in the blood was 3.41 mmol\/l, the lipid profile was normal. The patient\u2019s\u00a0previous ocular medical history was unremarkable.\nThe patient reported ocular complaints over the course of the last year, the main symptom of which was image distortion on the Amsler grid on the left eye. Baseline best corrected visual acuity of the left eye was 6\/10. Visual acuity in the right eye was 6\/6. In both eyes, the findings on the anterior segment corresponded to the patient\u2019s\u00a0age, with the exception of incipient cortical cataract. On the fundus of both eyes, the border of the optic nerve was demarcated, in the macula of the left eye there were a\u00a0number of soft confluent drusen, in the central periphery there were no pathological changes. On the fundus of the right eye the finding was similar, but to a\u00a0lesser degree. Optical coherence tomography on the macula of the left eye showed drusoid ablation of the retinal pigment epithelium (RPE), with accumulation of hyperreflectivities below the RPE. Pattern-reversal electroretinography (pERG): showed a\u00a0slightly prolonged retention of the activity of the central region of the retina (p50 wave) and ganglion cells (N95 wave). Multifocal electroretinography (mfERG) in the central 30\u00b0 of the retina was within normal limits. Electroretinography (ERG) demonstrated physiological photopic and scotopic rod activity. The patient was treated with 8 RhF procedures, two per week, with a\u00a02-week interval, and the pulse was repeated 4 times.\nResults: We noted a\u00a0gradual resorption of soft drusen in the patient, with attachment to the RPE line according to OCT examination at the following six-monthly check-ups over the next 6 years. Visual acuity of both eyes was maintained at the baseline values at the last check-up in April 2020, the area of soft drusen was significantly reduced. The function of the rod, cone system and the central region of the retina mfERG fluctuated only to an insignificant degree during the entire follow-up period, with a\u00a0tendency towards a\u00a0slight increase in activity after RhF treatment.\nConclusion: We noted an improvement of the anatomical and functional findings in a\u00a0patient with dry form of AMD during a\u00a06-year follow-up period after RhF treatment. The visual acuity of the affected eye remained at the baseline values.<\/jats:p>","DOI":"10.31348\/2023\/5","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T10:42:56Z","timestamp":1688812976000},"page":"42-46","source":"Crossref","is-referenced-by-count":0,"title":["Rheohemapheresis in the Treatment of Dry Form of AMD. A Case Report"],"prefix":"10.31348","volume":"79","author":[{"given":"Alexandr","family":"St\u011bpanov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Langrov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Studni\u010dka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marya","family":"Burova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16213","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref0","unstructured":"Blaha M, Rencova E, Blaha V, et al. Significance of changes in microcirculation during hemorheopheretic therapy of age related macular degeneration \u2013 our experience. Vnit\u0159. L\u00e9k. 2006;52(11):1102."},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Bressler NM. Age-related macular degeneration is the leading cause of blindness. JAMA. 2004;291:1900-1901.","DOI":"10.1001\/jama.291.15.1900"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Figueroa M, Schocket LS, DuPont J, Metelitsina TI, Grunwald JE. Long-term effect of laser treatment for dry age-related macular degeneration on choroidal hemodynamics. Am J Ophthalmol. 2006;141(5):863-867.","DOI":"10.1016\/j.ajo.2005.11.049"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Friberg TR, Musch DC, Lim JI. PTAMD Study Group: Prophylactic fragment of age-related macular degeneration report number l: 810 nanometer laser to eyes with drusen. Unilaterally eligible patients. Ophthalmology. 2006;113(4):622.","DOI":"10.1016\/j.ophtha.2005.10.066"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Klein R, Klein, BEK, Kn\u00fcdtson MD, et al. Fifteen-year cumulative incidence of age-related macular degeneration. The Beaver Dam Eye Study. Ophthalmology. 2007;114:253-291.","DOI":"10.1136\/bjo.2006.103796"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Schwartz J, Padmanabhan A, Aqui N, et al. Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Seventh Special Issue. J Clin Apher. 2016;31(3):149-162.","DOI":"10.1002\/jca.21470"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Rencova E, Blaha M, Studnicka J, et al. Reduction in the drusenoid retinal pigment epithelium detachment area in the dry form of age-related macular degeneration 2.5 years after rheohemapheresis. Acta Ophthalmol. 2013;91(5):e406-8.","DOI":"10.1111\/j.1755-3768.2012.02503.x"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Nowak I, Gajewicz W, Stefanczyk L, Omulecki W. Przep\u0142yw krwi w naczyniach oka u chorych na posta\u0107 sucha i wysiekowa starczego zwyrodnienia plamki (AMD) badany metoda, kolorowej ultrasonografii dopplerowskiej (USG-CD) [Color Doppler imaging of the retrobulbar circulation in non-exudative and exudative age-related macular degeneration]. Klin Oczna. 2005;107(1-3):63-67.","DOI":"10.5114\/ko.2019.84560"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Klingel R, Fassbender C, Heibges A, et al. RheoNet registry analysis of rheopheresis for microcirculatory disorders with a focus on age-related macular degeneration. Ther Apher Dial. 2010;14(3):276-286.","DOI":"10.1111\/j.1744-9987.2010.00807.x"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Pulido JS, Winters JL, Boyer, D. Preliminary analysis of the final multicenter investigation of rheopheresis for age related macular degeneration (AMD) trial (MIRA-l) results. Trans. Am. Ophthalmol. Soc. 2006;104:221-231.","DOI":"10.1007\/978-3-7091-7985-7_18"}],"container-title":["Czech and Slovak Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T10:43:00Z","timestamp":1688812980000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.cs-ophthalmology.cz\/en\/journal\/articles\/269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,20]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,2,20]]},"published-print":{"date-parts":[[2023,2,20]]}},"URL":"https:\/\/doi.org\/10.31348\/2023\/5","relation":{},"ISSN":["1805-4447","1211-9059"],"issn-type":[{"value":"1805-4447","type":"electronic"},{"value":"1211-9059","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2,20]]}}}