{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:11:20Z","timestamp":1778663480384,"version":"3.51.4"},"reference-count":0,"publisher":"Czech Society of Ophthalmology of the CzMA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cesk Slov Oftalmol"],"published-print":{"date-parts":[[2026,1,29]]},"abstract":"<jats:p>Aim: To evaluate RNFL (Retinal Nerve Fiber Layer) and GCC (Ganglion Cell Complex) thickness, using SD-OCT in treatment-naive patients of primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG) and normal-tension glaucoma (NTG) and to compare these findings with healthy controls.\n\nMaterial and Methods: The study included 150 eyes of 75 glaucoma patients (25 each of POAG, PACG, NTG) and 200 eyes of 100 controls. In this cross-sectional observational study, patients meeting the inclusion criteria underwent comprehensive ophthalmic examinations, including best-corrected visual acuity, intraocular pressure (IOP) by Goldmann applanation tonometry (GAT), gonioscopy to differentiate between open and closed angle and visual field analysis (VFA). GCC-IPL and RNFL thickness were measured using SD-OCT.\n\nResults: Significant thinning of RNFL was noted in all glaucoma subtypes, especially in inferior and superior quadrants (p &lt; 0.0001). GCC also showed thinning, notably in inferior and superior sectors, although the average GCC reduction was not statistically significant overall (p = 0.0611). Visual field mean deviation (MD) was worse in glaucoma eyes (-2.69 dB) compared to controls (-0.89 dB, p = 0.041), reflecting functional loss. POAG and NTG showed more prominent GCC, RNFL, VF correlations than PACG.\n\nConclusion: The study highlights that RNFL remains a robust early biomarker of glaucomatous damage, while inferior and superior GCC thickness may enhance sensitivity in detecting early structural changes, especially in treatment-naive patients. Combining RNFL and GCC analysis with VFA strengthens early diagnosis and subtype differentiation in treatment-naive primary glaucoma.<\/jats:p>","DOI":"10.31348\/2026\/5","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:25:57Z","timestamp":1778509557000},"source":"Crossref","is-referenced-by-count":0,"title":["Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness Analysis in Treatment \u2013 Naive Glaucoma Patients"],"prefix":"10.31348","author":[{"given":"Kumar","family":"Sushil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankita","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhupesh","family":"Bhatkoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Ambiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vipin","family":"Rana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16213","published-online":{"date-parts":[[2026,1,29]]},"container-title":["Czech and Slovak Ophthalmology"],"original-title":[],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:27:38Z","timestamp":1778660858000},"score":1,"resource":{"primary":{"URL":"https:\/\/cs-ophthalmology.cz\/en\/journal\/articles\/412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.31348\/2026\/5","relation":{},"ISSN":["1211-9059","1805-4447"],"issn-type":[{"value":"1211-9059","type":"print"},{"value":"1805-4447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]}}}