{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:54:39Z","timestamp":1764402879099,"version":"3.38.0"},"reference-count":33,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Liver Journal"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Vancouver\u2019s Downtown Eastside (DTES) faces the interrelated challenges of poverty, homelessness, mental health, addiction, and medical issues such as hepatitis C virus (HCV). This study evaluates a new model of engagement with people who inject drugs (PWID) in the DTES. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Our centre has developed the community pop-up clinic (CPC) to engage vulnerable populations such as PWID. Rapid HCV testing is offered using the OraQuick saliva assay. If a test is positive, immediate medical consultation and an incentivized clinic appointment are offered. At this appointment, an HCV treatment plan is developed, along with a plan for engagement in multidisciplinary care. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> In 12 months, 1,283 OraQuick tests were performed at 44 CPCs; 21% of individuals were found to be positive for HCV (68% of whom were PWID). Of individuals positive for HCV antibodies who consulted with the on-site doctor, 50% engaged in care in our clinic\u201461% of whom have initiated interferon-free directly acting antiviral (DAA) HCV therapy with 100% cured of HCV (per protocol). Individuals who did not engage in care were significantly more likely to be homeless (P &lt; .0001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> CPCs paired with a multidisciplinary model of care address the needs of vulnerable populations such as PWID, particularly in the management of HCV with interferon-free DAA therapies. <\/jats:p><\/jats:sec>","DOI":"10.3138\/canlivj.1.2.002","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T15:47:41Z","timestamp":1531842461000},"page":"14-33","source":"Crossref","is-referenced-by-count":21,"title":["Diagnosis and treatment of hepatitis C virus infection: a tool for engagement with people who inject drugs in Vancouver\u2019s Downtown Eastside"],"prefix":"10.3138","volume":"1","author":[{"given":"Arshia","family":"Alimohammadi","sequence":"first","affiliation":[{"name":"Vancouver Infectious Diseases Centre, Vancouver, British Columbia, Canada"},{"name":"These authors contributed equally to the article."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Holeksa","sequence":"additional","affiliation":[{"name":"Vancouver Infectious Diseases Centre, Vancouver, British Columbia, Canada"},{"name":"These authors contributed equally to the article."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Parsons","sequence":"additional","affiliation":[{"name":"Vancouver Infectious Diseases Centre, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossita","family":"Yung","sequence":"additional","affiliation":[{"name":"Vancouver Infectious Diseases Centre, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neilofar","family":"Amiri","sequence":"additional","affiliation":[{"name":"Vancouver Infectious Diseases Centre, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Truong","sequence":"additional","affiliation":[{"name":"Vancouver Infectious Diseases Centre, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Conway","sequence":"additional","affiliation":[{"name":"Vancouver Infectious Diseases Centre, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","reference":[{"key":"r1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S2468-1253(16)30181-9","volume":"2","author":"Blach S","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"12","key":"r2","doi-asserted-by":"crossref","first-page":"e1192","DOI":"10.1016\/S2214-109X(17)30375-3","volume":"5","author":"Degenhardt L","year":"2017","journal-title":"Lancet Glob Health"},{"key":"r3","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/liv.12370","volume":"34","author":"Alavi M","year":"2014","journal-title":"Liver Int"},{"key":"r4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10900-007-9083-3","volume":"33","author":"Mehta SH","year":"2008","journal-title":"J Community Health"},{"key":"r5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1155\/2014\/317623","volume":"28","author":"Myers RP","year":"2014","journal-title":"Can J Gastroenterol Hepatol"},{"key":"r6","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s11606-007-0183-7","volume":"22","author":"Wen CK","year":"2007","journal-title":"J Gen Intern Med"},{"key":"r7","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1089\/apc.2007.9990","volume":"21","author":"Rajabiun S","year":"2007","journal-title":"AIDS Patient Care STDS"},{"key":"r8","unstructured":"8. 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