{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:00:30Z","timestamp":1772618430845,"version":"3.50.1"},"reference-count":11,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Association of Medical Microbiology and Infectious Disease Canada"],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:p> Mycoplasma orale is an obligate intracellular bacterium usually found as a commensal in the human oral cavity. Symptomatic infections with this organism are rare, but severe disease has been described in the setting of impaired humoral immunity. Here, we describe a case in which M. orale was identified from the joint fluid of a patient with septic arthritis, splenic lesions, and agammaglobulinemia. A 15-year-old boy was admitted to the hospital with fever, progressive left knee swelling, and pain. His medical history was significant for Burkitt\u2019s lymphoma, the treatment of which had included rituximab 6 years earlier. M. orale was identified in the synovial fluid using 16S ribosomal RNA gene sequencing. He was also found to be hypogammaglobulinemic, and imaging revealed multiple splenic lesions. He was treated with doxycycline and intravenous immunoglobulin, which resulted in complete resolution of his arthritis and other symptoms. Mycoplasma species should be suspected in patients with humoral immunodeficiency and compatible findings. <\/jats:p>","DOI":"10.3138\/jammi-2021-0002","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T15:27:13Z","timestamp":1634052433000},"page":"333-336","source":"Crossref","is-referenced-by-count":2,"title":["Septic arthritis due to<i> Mycoplasma orale <\/i>in a young patient with hypogammaglobulinemia"],"prefix":"10.3138","volume":"6","author":[{"given":"Aaron C","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Paediatrics, University of British Columbia and BC Children\u2019s Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of British Columbia and BC Children\u2019s Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of British Columbia and BC Children\u2019s Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyla","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of British Columbia and BC Children\u2019s Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia and BC Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soren","family":"Gantt","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectiology and Immunology, Universit\u00e9 de Montr\u00e9al and CHU Sainte-Justine, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada N","family":"Al-Rawahi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, and BC Children\u2019s Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","reference":[{"key":"r1","doi-asserted-by":"crossref","first-page":"4210129","DOI":"10.1155\/2016\/4210129","volume":"2016","author":"Payne M","year":"2016","journal-title":"Can J Infect Dis Med Microbiol"},{"issue":"2","key":"r2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0732-8893(02)00429-7","volume":"44","author":"Paessler M","year":"2002","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"4","key":"r3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0002-9343(86)90812-0","volume":"80","author":"Roifman CM","year":"1986","journal-title":"Am J Med"},{"issue":"1","key":"r4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/oxfordjournals.aje.a120454","volume":"80","author":"Taylor-Robinson D","year":"1964","journal-title":"Am J Epidemiol"},{"issue":"6","key":"r5","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/rheumatology\/36.6.661","volume":"36","author":"Franz A","year":"1997","journal-title":"Br J Rheumatol"},{"key":"r6","first-page":"1","author":"Ketchersid J","year":"2020","journal-title":"Case Rep Infect Dis"},{"issue":"5","key":"r7","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jaip.2014.06.003","volume":"2","author":"Kaplan B","year":"2014","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"1","key":"r8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12969-019-0365-y","volume":"17","author":"Khojah AM","year":"2019","journal-title":"Pediatr Rheumatol Online"},{"issue":"2","key":"r9","first-page":"1","volume":"14","author":"McCusker C","year":"2018","journal-title":"Asthma Clin Immunol"},{"key":"r10","doi-asserted-by":"crossref","unstructured":"10. Tangye SG. XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP. J Clin Immunol. 2014;34:772\u20139. https:\/\/link.springer.com\/article\/10.1007\/s10875-014-0083-7","DOI":"10.1007\/s10875-014-0083-7"},{"issue":"9","key":"r11","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1128\/JCM.01228-07","volume":"45","author":"Janda JM","year":"2007","journal-title":"J Clin Microbiol"}],"container-title":["Journal of the Association of Medical Microbiology and Infectious Disease Canada"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.3138\/jammi-2021-0002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T16:16:00Z","timestamp":1741882560000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.3138\/jammi-2021-0002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12,1]]}},"alternative-id":["10.3138\/jammi-2021-0002"],"URL":"https:\/\/doi.org\/10.3138\/jammi-2021-0002","relation":{},"ISSN":["2371-0888","2371-0888"],"issn-type":[{"value":"2371-0888","type":"print"},{"value":"2371-0888","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}