{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:38:15Z","timestamp":1790033895522,"version":"4.0.1"},"reference-count":43,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Association of Medical Microbiology and Infectious Disease Canada"],"published-print":{"date-parts":[[2024,12,19]]},"abstract":"<jats:p> Eight provinces and territories are currently experiencing syphilis outbreaks in Canada, with the national rate of infectious\u00a0syphilis\u00a0increasing significantly from 5.1 per 100,000 population in 2011 to 36.1 per 100,000 population in 2022. Neurosyphilis refers to infection of the central nervous system by Treponema pallidum, which may occur at any stage. It is to be expected that along with the syphilis outbreak, a concomitant rise in neurosyphilis cases will occur. It is important to note that Canadian national surveillance data on neurosyphilis is not currently published as it is inconsistently reported and often lumped in with secondary and tertiary syphilis rates. Future surveillance efforts must focus on properly identifying these cases to quantify the scope of the problem. This article summarizes Canadian Public Health Laboratory Network guidelines for neurosyphilis diagnosis. <\/jats:p>","DOI":"10.3138\/jammi-2024-0022","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T15:32:09Z","timestamp":1734622329000},"page":"219-228","source":"Crossref","is-referenced-by-count":2,"title":["Canadian Public Health Laboratory Network (CPHLN) diagnostic recommendations for neurosyphilis in Canada"],"prefix":"10.3138","volume":"9","author":[{"given":"Bev","family":"Wudel","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, University of Saskatchewan College of Medicine, Saskatoon, Saskatchewan"},{"name":"Section leads"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupeena","family":"Purewal","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Saskatchewan College of Medicine, Saskatoon, Saskatchewan"},{"name":"Section leads"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd F","family":"Hatchette","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Dalhousie University, Halifax, Nova Scotia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology & Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Morshed","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Minion","sequence":"additional","affiliation":[{"name":"Roy Romanow Provincial Laboratory for Public Health, Regina, Saskatchewan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Vall\u00e9e","sequence":"additional","affiliation":[{"name":"Institut National de Sant\u00e9 Publique du Qu\u00e9bec; Qu\u00e9bec"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Hayden","sequence":"additional","affiliation":[{"name":"Canadian Public Health Laboratory Network Secretariat, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Hamula","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine & Pathology, University of Saskatchewan College of Medicine, Saskatoon, Saskatchewan, Canada"},{"name":"Correspondence: Camille Hamula, Rm 3760, 103 Hospital Drive, Saskatoon, Saskatchewan, S7N 0W8 Canada. Telephone: 306-321-5920."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1696","reference":[{"key":"r1","first-page":"18A","volume":"26","author":"Wong T","year":"2015","journal-title":"Can J Infect Dis Med Microbiol"},{"issue":"5","key":"r2","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1111\/j.1755-5949.2010.00183.x","volume":"16","author":"Ghanem KG","year":"2010","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"r3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11908-009-0019-1","volume":"11","author":"Marra CM","year":"2009","journal-title":"Curr Infect Dis Rep"},{"issue":"11","key":"r4","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1001\/jama.290.11.1510","volume":"290","author":"Golden MR","year":"2003","journal-title":"JAMA"},{"key":"r5","volume-title":"Shadow on the land. 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