{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T04:20:10Z","timestamp":1741926010679,"version":"3.38.0"},"reference-count":14,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Association of Medical Microbiology and Infectious Disease Canada"],"published-print":{"date-parts":[[2020,3,4]]},"abstract":"<jats:p> Necrotizing fasciitis of an extremity due to Haemophilus influenzae is exceptionally uncommon in adults, particularly since the advent of widespread vaccination with conjugated H. influenzae type b (Hib). We report a previously vaccinated, 39-year-old male with a history of common variable immunodeficiency (CVID), poorly compliant with intravenous immunoglobulin (IVIG) therapy, who required emergent treatment for left leg necrotizing fasciitis. The patient was initially treated with piperacillin-tazobactam, vancomycin, and clindamycin, in tandem with surgical debridement and wash-out. The patient responded well and completed a 2-week course of ceftriaxone following blood culture results that demonstrated beta-lactamase\u2013positive Hib. This is the fifth documented case of necrotizing fasciitis caused by H. influenzae, and the first affecting an adult with prior Hib vaccination. This case highlights the importance of IVIG compliance for CVID patients and advocates considering encapsulated organisms as part of the differential diagnosis for severe skin and soft tissue infections in this patient population. <\/jats:p>","DOI":"10.3138\/jammi.2019-0022","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T20:08:30Z","timestamp":1577995710000},"page":"44-48","source":"Crossref","is-referenced-by-count":0,"title":["<i>Haemophilus influenzae<\/i> type b necrotizing fasciitis in an adult with common variable immunodeficiency"],"prefix":"10.3138","volume":"5","author":[{"given":"Liam","family":"Finlay","sequence":"first","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Cvetkovic","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zain","family":"Chagla","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, St. Joseph\u2019s Hospital, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","reference":[{"issue":"9","key":"r1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1056\/NEJMcp031807","volume":"350","author":"Swartz MN","year":"2004","journal-title":"N Engl J Med"},{"issue":"5","key":"r2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/infdis\/130.5.489","volume":"130","author":"Norden CW","year":"1974","journal-title":"J Infect Dis"},{"issue":"2","key":"r3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1086\/516908","volume":"25","author":"Stumvoll M","year":"1997","journal-title":"Clin Infect Dis"},{"issue":"2","key":"r4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1099\/jmm.0.47603-0","volume":"57","author":"McLellan E","year":"2008","journal-title":"J Med Microbiol"},{"issue":"3","key":"r5","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/JCM.01196-08","volume":"47","author":"Saito T","year":"2009","journal-title":"J Clin Microbiol"},{"issue":"5","key":"r6","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1007\/s11999-009-1126-x","volume":"468","author":"Lee EY","year":"2010","journal-title":"Clin Orthop Relat Res"},{"key":"r7","unstructured":"7. Buckley R, Ballow M, Berger M, et\u00a0al. Immune Deficiency Foundation diagnostic & clinical care guidelines for primary immunodeficiency diseases [Internet]. 2nd ed. Towson, MD: Immune Deficiency Foundation; 2009 [cited 2019 Dec 12]. Available from: https:\/\/primaryimmune.org\/wp-content\/uploads\/2011\/04\/IDF-Diagnostic-Clinical-Care-Guidelines-for-Primary-Immunodeficiency-Diseases-2nd-Edition.pdf."},{"issue":"1","key":"r8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/trf.13869","volume":"57","author":"Lee S","year":"2017","journal-title":"Transfusion"},{"issue":"4","key":"r9","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.jaci.2013.11.043","volume":"133","author":"Medical Advisory Committee of the Immune Deficiency Foundation","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"r10","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1128\/CVI.05675-11","volume":"19","author":"Nix EB","year":"2012","journal-title":"Clin Vaccine Immunol"},{"issue":"11","key":"r11","doi-asserted-by":"crossref","first-page":"e112711","DOI":"10.1371\/journal.pone.0112711","volume":"9","author":"Puig C","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"r12","doi-asserted-by":"crossref","first-page":"e0142179","DOI":"10.1371\/journal.pone.0142179","volume":"10","author":"Desai S","year":"2015","journal-title":"PLoS One."},{"issue":"1","key":"r13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/107327481702400111","volume":"24","author":"Singh V","year":"2017","journal-title":"Cancer Control"},{"issue":"2","key":"r14","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/511159","volume":"44","author":"Mandell LA","year":"2007","journal-title":"Clin Infect Dis"}],"container-title":["Journal of the Association of Medical Microbiology and Infectious Disease Canada"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.3138\/jammi.2019-0022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T13:16:47Z","timestamp":1741871807000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.3138\/jammi.2019-0022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,4]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,3,4]]}},"alternative-id":["10.3138\/jammi.2019-0022"],"URL":"https:\/\/doi.org\/10.3138\/jammi.2019-0022","relation":{},"ISSN":["2371-0888"],"issn-type":[{"type":"electronic","value":"2371-0888"}],"subject":[],"published":{"date-parts":[[2020,3,4]]}}}