{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:36:51Z","timestamp":1779323811849,"version":"3.51.4"},"reference-count":9,"publisher":"Ant Publishing","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["APT"],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"<jats:p>A female UM-HET3 mouse from the Study of Longitudinal Aging in Mice (SLAM) was euthanized at 164 weeks of age due to hind limb weakness. Necropsy and histological analysis revealed that the most probable cause of the clinical finding was the compression of the thoracolumbar segment of the spinal cord by herniated intervertebral disks. In addition, a spontaneous chordoma was incidentally found in the coccygeal bones. Given the rarity of this type of tumor, bio-clinical annotations acquired throughout lifespan, detailed histopathological assessment, and comparative clinical-pathological correlations for this mouse are presented and discussed. Keywords: Geropathology, geroscience, study of longitudinal aging in mice (SLAM), spontaneous neoplasm, tumor burden, chordoma<\/jats:p>","DOI":"10.31491\/apt.2020.12.043","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T02:34:15Z","timestamp":1609382055000},"page":"219-222","source":"Crossref","is-referenced-by-count":1,"title":["Spontaneous chordoma: a case report on a female UM-HET3 mouse from the SLAM study"],"prefix":"10.31491","volume":"2","author":[{"name":"Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Duregon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Vieira","family":"Ligo Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"de Cabo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16464","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Palliyaguru D L, Vieira Ligo Teixeira C, Duregon E, et al. Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques (SLAM POET). The Journals of Gerontology: Series A, 2020.","DOI":"10.1093\/gerona\/glaa285"},{"issue":"4","key":"ref1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/geront\/4.4.185","article-title":"A New Research Building for Gerontology","volume":"4","author":"Shock N","year":"1964","unstructured":"2. Shock N W. A New Research Building for Gerontology. The Gerontologist, 1964, 4(4): 185-189.","journal-title":"The Gerontologist"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Gonzalez-Freire M, Diaz-Ruiz A, Hauser D, et al. The road ahead for health and lifespan interventions. Ageing Research Reviews, 2020: 101037.","DOI":"10.1016\/j.arr.2020.101037"},{"issue":"2","key":"ref3","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/s41596-019-0256-1","article-title":"A toolbox for the longitudinal assessment of healthspan in aging mice","volume":"15","author":"Bellantuono","year":"2020","unstructured":"4. Bellantuono I, de Cabo R, Ehninger D, et al. A toolbox for the longitudinal assessment of healthspan in aging mice. Nature protocols, 2020, 15(2): 540-574.","journal-title":"Nature protocols"},{"issue":"2","key":"ref4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1177\/0300985815610391","article-title":"Cause-of-death analysis in rodent aging studies","volume":"53","author":"Snyder J","year":"2016","unstructured":"5. Snyder J M, Ward J M, Treuting P M. Cause-of-death analysis in rodent aging studies. Veterinary pathology, 2016, 53(2): 233-243.","journal-title":"Veterinary pathology"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Walcott B P, Nahed B V, Mohyeldin A, et al. Chordoma: current concepts, management, and future directions. The lancet oncology, 2012, 13(2): e69-e76.","DOI":"10.1016\/S1470-2045(11)70337-0"},{"issue":"1","key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/A:1008947301735","article-title":"Chordoma: incidence and survival patterns in the United States, 1973-1995","volume":"12","author":"McMaster M","year":"2001","unstructured":"7. McMaster M L, Goldstein A M, Bromley C M, et al. Chordoma: incidence and survival patterns in the United States, 1973-1995. Cancer Causes & Control, 2001, 12(1): 1-11.","journal-title":"Cancer Causes & Control"},{"issue":"1","key":"ref7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/0300985815575051","article-title":"Chordomas at high prevalence in the captive population of the endangered Perdido Key beach mouse (Peromyscus polionotus trissyllepsis)","volume":"53","author":"Taylor K","year":"2016","unstructured":"8. Taylor K R, Garner M M, Russell K, et al. Chordomas at high prevalence in the captive population of the endangered Perdido Key beach mouse (Peromyscus polionotus trissyllepsis). Veterinary pathology, 2016, 53(1): 163- 169.","journal-title":"Veterinary pathology"},{"issue":"11","key":"ref8","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/ng.454","article-title":"T (brachyury) gene duplication confers major susceptibility to familial chordoma","volume":"41","author":"Yang X","year":"2009","unstructured":"9. Yang X R, Ng D, Alcorta D A, et al. T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nature genetics, 2009, 41(11): 1176-1178.","journal-title":"Nature genetics"}],"container-title":["Aging Pathobiology and Therapeutics"],"original-title":[],"link":[{"URL":"http:\/\/www.antpublisher.com\/index.php\/APT\/article\/download\/344\/394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T02:45:06Z","timestamp":1647485106000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.antpublisher.com\/index.php\/APT\/article\/view\/344\/394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,31]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,12,31]]},"published-print":{"date-parts":[[2020,12,31]]}},"URL":"https:\/\/doi.org\/10.31491\/apt.2020.12.043","relation":{},"ISSN":["2690-1803"],"issn-type":[{"value":"2690-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,31]]}}}