{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:32:15Z","timestamp":1773232335955,"version":"3.50.1"},"reference-count":24,"publisher":"Asian Spine Journal (ASJ)","issue":"1","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["asianspinejournal.org"],"crossmark-restriction":true},"short-container-title":["Asian Spine J"],"published-print":{"date-parts":[[2022,2,28]]},"abstract":"<jats:p>Study Design: Cross-sectional study.Purpose: To examine whether the number of continuous vertebral bone bridges and bone mineral density (BMD) influence the fracture risk in diffuse idiopathic skeletal hyperostosis (DISH) patients.Overview of Literature: Bone bridges connecting through the intervertebral body in DISH create long lever arms that can increase the risk of fractures from minor trauma. DISH patients have a BMD that is higher than or comparable to those of age-matched healthy subjects.Methods: We examined the computed tomography scans from the thoracic vertebra to the sacrum used to diagnose DISH in 140 patients (98 men and 42 women; average age, 78.6 years). We compared patients who did (n=52) and did not have (n=88) fractures at the continuous vertebral bodies fused by bone bridges. The relationship between the vertebral fractures and the maximum number of vertebrae that are bony cross-linked with contiguous adjacent vertebrae (max VB) from the thoracic vertebra to the sacrum or from the lumbar vertebra to the sacrum and proximal femur BMD were analyzed using a logistic regression model.Results: We found that after adjusting for the confounding factors, higher max VB, both from the thoracic vertebrae to the sacrum and the lumbar vertebrae to the sacrum, was associated with a higher risk of vertebral fractures. This difference was statistically significant. The risk was higher when only the lumbar vertebrae to the sacrum was considered (thoracic vertebrae to the sacrum: odds ratio, 1.21; p&lt;0.05; lumbar vertebrae to the sacrum: odds ratio, 2.78; p&lt;0.01). Moreover, low proximal femur BMD in DISH patients raises the fracture risk (odds ratio, 0.47; p&lt;0.01).Conclusions: Many continuous vertebral bone bridges, especially those that extend to the lumbar spine and low proximal femur BMD, are risk factors for fracture in DISH patients.<\/jats:p>","DOI":"10.31616\/asj.2020.0352","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:56:54Z","timestamp":1619744214000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.31616\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of Continuous Vertebral Bone Bridges and Bone Mineral Density with the Fracture Risk in Patients with Diffuse Idiopathic Skeletal Hyperostosis"],"prefix":"10.31616","volume":"16","author":[{"given":"Mitsuru","family":"Furukawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunimasa","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Yato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morio","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16744","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1148\/15.3.513"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(07)60635-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/bsd.0b013e3181679bcb"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4184\/asj.2017.11.1.63"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109\/03009747509095610"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171091"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.4.8141015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/sc.1977.19"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/brs.0b013e3181cc764f"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-008-0764-0"},{"key":"ref11","first-page":"E460","volume-title":"Prevalence and distribution of diffuse idiopathic skeletal hyperostosis on whole-spine computed tomography in patients with cervical ossification of the posterior longitudinal ligament: a multicenter study","author":"Nishimura","year":"2018"},{"key":"ref12","first-page":"1290","volume-title":"Bone loss is detected more frequently in patients with ankylosing spondylitis with syndesmophytes","author":"Karberg","year":"2005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7860\/jcdr\/2013\/6779.3770"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1409-9"},{"key":"ref15","first-page":"406","volume-title":"Diffuse idiopathic skeletal hyperostosis (DISH)","author":"Resnick","year":"1976"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1863-y"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2017"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.21037\/jss.2019.09.11"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-013-3088-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.31616\/asj.2018.0187"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep177"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2016.09.001"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.22603\/ssrr.2020-0001"},{"key":"ref24","first-page":"12","volume-title":"New diagnostic criteria for primary osteoporosis (2012 revision), diagnostic criteria for primary osteoporosis (2012 revision)","author":"Soen","year":"2013"}],"container-title":["Asian Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.asianspinejournal.org\/upload\/pdf\/asj-2020-0352.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.asianspinejournal.org\/journal\/view.php?doi=10.31616\/asj.2020.0352","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.asianspinejournal.org\/upload\/pdf\/asj-2020-0352.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T05:14:10Z","timestamp":1645506850000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.asianspinejournal.org\/journal\/view.php?doi=10.31616\/asj.2020.0352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"URL":"https:\/\/doi.org\/10.31616\/asj.2020.0352","relation":{},"ISSN":["1976-1902","1976-7846"],"issn-type":[{"value":"1976-1902","type":"print"},{"value":"1976-7846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]},"assertion":[{"value":"2020-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-28","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}