{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:15:03Z","timestamp":1783347303156,"version":"3.54.6"},"reference-count":13,"publisher":"Asian Spine Journal (ASJ)","issue":"2","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["asianspinejournal.org"],"crossmark-restriction":true},"short-container-title":["Asian Spine J"],"published-print":{"date-parts":[[2023,4,30]]},"abstract":"<jats:p>Study Design: Retrospective cohort study.Purpose: To evaluate the clinical outcomes of the conservative treatment of \u201cpre-lysis\u201d-stage lumbar spondylolysis.Overview of Literature: With the widespread use of magnetic resonance imaging (MRI) for early diagnosis of lumbar spondylolysis, a new disease stage called pre-lysis has emerged, in which intensity change is observed only on MRI without a fracture line on computed tomography. This study aimed to evaluate the clinical outcomes and factors unfavorable to bone healing of the conservative treatment of pre-lysis-stage lumbar spondylolysis.Methods: Fifty-three patients with 57 fresh pre-lysis-stage lesions who had completed conservative treatment were included in the study (40 men, 13 women; mean age, 14.3 years). We investigated the rate of bone healing and the relationship between bone healing after conservative therapy and factors such as age, sex, vertebral level, unilateral\/bilateral lesions, and presence of spina bifida occulta.Results: The overall bone healing rate was 95% (54\/57 lesions). Bilateral lesions had a significantly lower bone healing rate than unilateral lesions (86% vs. 100%, p=0.046). There were no statistically significant differences based on age, sex, vertebral level, or presence of spina bifida occulta.Conclusions: The bone healing rate in unilateral lesions was 100%, which was significantly higher than that in bilateral lesions. It is important to detect and initiate treatment while the lesion is still unilateral, if possible.<\/jats:p>","DOI":"10.31616\/asj.2022.0007","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T05:56:51Z","timestamp":1661147811000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.31616\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Conservative Treatment and Unfavorable Factors to Bone Healing of \u201cPre-lysis\u201d-Stage Lumbar Spondylolysis in Adolescents"],"prefix":"10.31616","volume":"17","author":[{"given":"Hisanori","family":"Gamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Tatsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Okuwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16744","reference":[{"key":"ref1","first-page":"206","volume-title":"Conservative treatment of lumbar spondylolysis in childhood and adolescence: the radiological signs which predict healing","author":"Sairyo","year":"2009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2021.03.004"},{"key":"ref3","first-page":"225","volume-title":"Union of defects in the pars interarticularis of the lumbar spine in children and adolescents: the radiological outcome after conservative treatment","author":"Fujii","year":"2004"},{"key":"ref4","first-page":"206","volume-title":"MRI signal changes of the pedicle as an indicator for early diagnosis of spondylolysis in children and adolescents: a clinical and biomechanical study","author":"Sairyo","year":"2006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2021.01.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/brs.0b013e3181c9f2a2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/brs.0000000000001931"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-020-03940-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-013-3109-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.22603\/ssrr.2018-0012"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.31616\/asj.2020.0309"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/brs.0b013e3181b4abbe"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2012.716046"}],"container-title":["Asian Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.asianspinejournal.org\/upload\/pdf\/asj-2022-0007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.asianspinejournal.org\/journal\/view.php?doi=10.31616\/asj.2022.0007","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.asianspinejournal.org\/upload\/pdf\/asj-2022-0007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T05:05:46Z","timestamp":1682485546000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.asianspinejournal.org\/journal\/view.php?doi=10.31616\/asj.2022.0007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,30]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.31616\/asj.2022.0007","relation":{},"ISSN":["1976-1902","1976-7846"],"issn-type":[{"value":"1976-1902","type":"print"},{"value":"1976-7846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,30]]},"assertion":[{"value":"2022-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-23","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}