{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:51:17Z","timestamp":1780926677620,"version":"3.54.1"},"reference-count":19,"publisher":"Asian Spine Journal (ASJ)","issue":"3","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["GA64\/023"],"award-info":[{"award-number":["GA64\/023"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["90_49_2_64_006"],"award-info":[{"award-number":["90_49_2_64_006"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asianspinejournal.org"],"crossmark-restriction":true},"short-container-title":["Asian Spine J"],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:p>Study Design: A prospective analytic study.Purpose: To investigate the clinical factors and magnetic resonance imaging (MRI) findings that can predict a favorable outcome following transforaminal epidural steroid injection (TFESI) in patients with lumbosacral radiculopathy.Overview of Literature: The efficacy of lumbar epidural steroid injection varies, and no clinical parameters have been established to predict a favorable response to TFESI reliably.Methods: In total, 120 patients diagnosed with lumbosacral radiculopathy underwent TFESI. At each index spinal level, 5.0 mg of a dexamethasone mixture in 2.0% lidocaine and 0.5% bupivacaine was injected. At the 2-week follow-up, a favorable response to TFESI was defined as pain reduction upon movement of &gt;50.0%. Pain manifestation and MRI findings were evaluated.Results: A favorable response was observed in 60.8% of the patients 2 weeks post-TFESI. In the multivariate analysis, patients with mild central canal stenosis had 4.8 times higher odds of a favorable response to TFESI than those with severe central canal stenosis (adjusted odds ratio, 4.8; 95% confidence interval [CI], 1.2\u201318.8; p =0.023). Favorable responders experienced a notable 29-week period of pain reduction (95% CI, 10.3\u201347.8), along with a significantly lower incidence of surgery at 12 months (13.7%) (p &lt;0.01). The mean pain score differences of 3.5 out of 10 observed 2 weeks and 1 month post-TFESI represented the optimal sensitivity and specificity in forecasting favorable responder status.Conclusions: A pain reduction of 3.5 out of 10 within 1 month is considered a clinical benchmark for predicting long-term positive outcomes after TFESI. The presence of severe central canal stenosis is significantly associated with an unfavorable response to TFESI.<\/jats:p>","DOI":"10.31616\/asj.2024.0412","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T06:24:42Z","timestamp":1741069482000},"page":"422-431","update-policy":"https:\/\/doi.org\/10.31616\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and radiographic predictive factors for the favorable outcome of lumbar epidural steroid injection in lumbosacral radiculopathy: a prospective analytical study from 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