{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:18:20Z","timestamp":1792811900954,"version":"4.5.0"},"reference-count":29,"publisher":"Asian Spine Journal (ASJ)","issue":"3","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["asianspinejournal.org"],"crossmark-restriction":true},"short-container-title":["Asian Spine J"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>Study Design: Systematic review and meta-analysis.Purpose: To investigate the efficacy and safety of intradiscal mesenchymal stem cell (MSC) injection for patients with degenerative disc disease (DDD).Overview of Literature: DDD is a common cause of chronic low-back pain (CLBP). Studies have shown that MSC therapy may have the potential to reverse the degenerative process. However, the evidence remains inconclusive.Methods: A comprehensive search of Europe PMC, Cochrane Library, Scopus, and Medline was conducted up to April 30, 2025, using relevant keywords. Randomized controlled trials (RCTs) comparing intradiscal MSC injections with sham\/placebo in patients with DDD were included. Random-effects models were used to calculate the odds ratios and mean differences (MDs).Results: Seven RCTs were included. MSC injection was associated with significantly greater reductions in Visual Analog Scale pain scores (MD, 6.67; 95% confidence interval [CI], \u22129.31 to \u22124.02; p&lt;0.00001, I&lt;sup&gt;2&lt;\/sup&gt;=29%) and Oswestry Disability Index (ODI) (MD, \u22124.05%; 95% CI, \u22125.24 to \u22122.87; p&lt;0.00001, I&lt;sup&gt;2&lt;\/sup&gt;=32%) compared with sham\/placebo. The magnitude of improvement increased with longer followup. No significant differences were observed between groups in treatment-emergent adverse events (AEs), serious AEs, treatment discontinuation due to AEs, or mortality.Conclusions: Intradiscal MSC injection appears to be a safe and effective therapy, offering modest improvements in pain and function for patients with CLBP due to DDD who do not respond to conservative treatments.<\/jats:p>","DOI":"10.31616\/asj.2025.0354","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:20:27Z","timestamp":1773706827000},"page":"541-557","update-policy":"https:\/\/doi.org\/10.31616\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intradiscal mesenchymal stem cell therapy for degenerative disc disease: a systematic review and meta-analysis of randomized trials"],"prefix":"10.31616","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3248-1147","authenticated-orcid":true,"given":"Ahmad Jabir","family":"Rahyussalim","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"},{"name":"Stem Cell Medical Technology Installation, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia"},{"name":"Stem Cells and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6588-7366","authenticated-orcid":true,"given":"Satria Wisnu","family":"Murti","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5619-6356","authenticated-orcid":true,"given":"Rudi","family":"Thenggono","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9822-4842","authenticated-orcid":true,"given":"Faiza Al Khalifa","family":"Calista","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic & Traumatology, Bhayangkara Mohammad Hasan Hospital, Palembang, 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