{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:30:07Z","timestamp":1771489807708,"version":"3.50.1"},"reference-count":38,"publisher":"The Society for Free Radical Research Japan","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Biochem. Nutr."],"published-print":{"date-parts":[[2014]]},"DOI":"10.3164\/jcbn.14-39","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T23:35:17Z","timestamp":1413848117000},"page":"155-161","source":"Crossref","is-referenced-by-count":12,"title":["S-allyl cysteine ameliorates the quality of sperm and provides protection from age-related sperm dysfunction and oxidative stress in rats"],"prefix":"10.3164","volume":"55","author":[{"given":"Shigekazu","family":"Takemura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohisa","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikazu","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Minamiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1739","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Hirsh A. Male subfertility. Bmj 2003; 327: 669\u2013672.","DOI":"10.1136\/bmj.327.7416.669"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Minamiyama Y, Ichikawa H, Takemura S, Kusunoki H, Naito Y, Yoshikawa T. Generation of reactive oxygen species in sperms of rats as an earlier marker for evaluating the toxicity of endocrine-disrupting chemicals. Free Radic Res 2010; 44: 1398\u20131406.","DOI":"10.3109\/10715762.2010.510523"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Agarwal A, Sharma RK, Nallella KP, Thomas AJ Jr, Alvarez JG, Sikka SC. Reactive oxygen species as an independent marker of male factor infertility. Fertil Steril 2006; 86: 878\u2013885.","DOI":"10.1016\/j.fertnstert.2006.02.111"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Agarwal A, Ikemoto I, Loughlin KR. Levels of reactive oxygen species before and after sperm preparation: comparison of swim-up and L4 filtration. Arch Androl 1994; 32: 169\u2013174.","DOI":"10.3109\/01485019408987783"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Nakamura BN, Lawson G, Chan JY, et al. Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner. Free Radical Biol Med 2010; 49: 1368\u20131379.","DOI":"10.1016\/j.freeradbiomed.2010.07.019"},{"key":"6","unstructured":"6 Agarwal A, Prabakaran SA. Mechanism, measurement, and prevention of oxidative stress in male reproductive physiology. Indian J Exp Biol 2005; 43: 963\u2013974."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Col\u00edn-Gonz\u00e1lez AL, Santana RA, Silva-Islas CA, Ch\u00e1nez-C\u00e1rdenas ME, Santamar\u00eda A, Maldonado PD. The antioxidant mechanisms underlying the aged garlic extract- and <i>S<\/i>-allylcysteine-induced protection. Oxid Med Cell Longev 2012; 2012: 907162.","DOI":"10.1155\/2012\/907162"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Nagae S, Ushijima M, Hatono S, et al. Pharmacokinetics of the garlic compound <i>S<\/i>-allylcysteine. Planta Med 1994; 60: 214\u2013217.","DOI":"10.1055\/s-2006-959461"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Steiner M, Li W. Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions. J Nutr 2001; 131: 980S\u2013984S.","DOI":"10.1093\/jn\/131.3.980S"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Kahle PJ, Waak J, Gasser T. DJ-1 and prevention of oxidative stress in Parkinson\u2019s disease and other age-related disorders. Free Radic Biol Med 2009; 47: 1354\u20131361.","DOI":"10.1016\/j.freeradbiomed.2009.08.003"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Wang J, Wang J, Zhang HR, et al. Proteomic analysis of seminal plasma from asthenozoospermia patients reveals proteins that affect oxidative stress responses and semen quality. Asian J Androl 2009; 11: 484\u2013491.","DOI":"10.1038\/aja.2009.26"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Kinumi T, Kimata J, Taira T, Ariga H, Niki E. Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation <i>in vivo<\/i> in human umbilical vein endothelial cells. Biochem Biophys Res Commun 2004; 317: 722\u2013728.","DOI":"10.1016\/j.bbrc.2004.03.110"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Wilson MA. The role of cysteine oxidation in DJ-1 function and dysfunction. Antioxid Redox Signal 2011; 15: 111\u2013122.","DOI":"10.1089\/ars.2010.3481"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Mizuguchi S, Takemura S, Minamiyama Y, et al. <i>S<\/i>-allyl cysteine attenuated CCl4-induced oxidative stress and pulmonary fibrosis in rats. Biofactors 2006; 26: 81\u201392.","DOI":"10.1002\/biof.5520260108"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Takemura S, Minamiyama Y, Kodai S, et al. <i>S<\/i>-Allyl cysteine improves nonalcoholic fatty liver disease in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats via regulation of hepatic lipogenesis and glucose metabolism. J Clin Biochem Nutr 2013; 53: 94\u2013101.","DOI":"10.3164\/jcbn.13-1"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Isobe T. New method to estimate the possibility of natural pregnancy using computer-assisted sperm analysis. Syst Biol Reprod Med 2012; 58: 339\u2013347.","DOI":"10.3109\/19396368.2012.700759"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Signorini C, De Felice C, Durand T, et al. Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder. Oxid Med Cell Longev 2013; 2013: 343824.","DOI":"10.1155\/2013\/343824"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Gratzner HG. Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: a new reagent for detection of DNA replication. Science 1982; 218: 474\u2013475.","DOI":"10.1126\/science.7123245"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Meldrum DR, Gambone JC, Morris MA, Esposito K, Giugliano D, Ignarro LJ. Lifestyle and metabolic approaches to maximizing erectile and vascular health. Int J Impot Res 2012; 24: 61\u201368.","DOI":"10.1038\/ijir.2011.51"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Kierszenbaum AL. Tyrosine protein kinases and spermatogenesis: truncation matters. Mol Reprod Dev 2006; 73: 399\u2013403.","DOI":"10.1002\/mrd.20456"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Kodai S, Takemura S, Minamiyama Y, et al. <i>S<\/i>-allyl cysteine prevents CCl(4)-induced acute liver injury in rats. Free Radic Res 2007; 41: 489\u2013497.","DOI":"10.1080\/10715760601118361"},{"key":"22","unstructured":"22 Shinkawa H, Takemura S, Minamiyama Y, et al. <i>S<\/i>-allylcysteine is effective as a chemopreventive agent against porcine serum-induced hepatic fibrosis in rats. Osaka City Med J 2009; 55: 61\u201369."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Ray B, Chauhan NB, Lahiri DK. The \u201daged garlic extract:\u201d (AGE) and one of its active ingredients <i>S<\/i>-allyl-L-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer\u2019s disease (AD). Curr Med Chem 2011; 18: 3306\u20133313.","DOI":"10.2174\/092986711796504664"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Yoshida K, Sato Y, Yoshiike M, Nozawa S, Ariga H, Iwamoto T. Immunocytochemical localization of DJ-1 in human male reproductive tissue. Mol Reprod Dev 2003; 66: 391\u2013397.","DOI":"10.1002\/mrd.10360"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Meulener MC, Xu K, Thomson L, Ischiropoulos H, Bonini NM. Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc Natl Acad Sci U S A 2006; 103: 12517\u201312522.","DOI":"10.1073\/pnas.0601891103"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Froman DP, Feltmann AJ. Sperm mobility: a quantitative trait of the domestic fowl (Gallus domesticus). Biol Reprod 1998; 58: 379\u2013384.","DOI":"10.1095\/biolreprod58.2.379"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Ruiz-Pesini E, Diez C, Lape\u00f1a AC, et al. Correlation of sperm motility with mitochondrial enzymatic activities. Clin Chem 1998; 44: 1616\u20131620.","DOI":"10.1093\/clinchem\/44.8.1616"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Ruiz-Pesini E, Diez-S\u00e1nchez C, L\u00f3pez-P\u00e9rez MJ, Enr\u00edquez JA. The role of the mitochondrion in sperm function: is there a place for oxidative phosphorylation or is this a purely glycolytic process? Curr Top Dev Biol 2007; 77: 3\u201319.","DOI":"10.1016\/S0070-2153(06)77001-6"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Luconi M, Muratori M, Forti G, Baldi E. Identification and characterization of a novel functional estrogen receptor on human sperm membrane that interferes with progesterone effects. J Clin Endocrinol Metab 1999; 84: 1670\u20131678.","DOI":"10.1210\/jcem.84.5.5670"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Hess RA, Bunick D, Bahr JM. Sperm, a source of estrogen. Environ Health Perspect 1995; 103 (Suppl 7): 59\u201362.","DOI":"10.1289\/ehp.95103s759"},{"key":"31","unstructured":"31 Wang ZQ, Zhou HY, Chen SD. The role of DJ-1 in the pathogenesis of Parkinson\u2019s disease. Neurosci Bull 2006; 22: 232\u2013234."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Honbou K, Suzuki NN, Horiuchi M, et al. The crystal structure of DJ-1, a protein related to male fertility and Parkinson\u2019s disease. J Biol Chem 2003; 278: 31380\u201331384.","DOI":"10.1074\/jbc.M305878200"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Luo C, Li Y, Wang H, Feng Z, Long J, Liu J. Mitochondrial accumulation under oxidative stress is due to defects in autophagy. J Cell Biochem 2013; 114: 212\u2013219.","DOI":"10.1002\/jcb.24356"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Tsai SJ, Chiu CP, Yang HT, Yin MC. s-Allyl cysteine, s-ethyl cysteine, and s-propyl cysteine alleviate \u03b2-amyloid, glycative, and oxidative injury in brain of mice treated by D-galactose. J Agric Food Chem 2011; 59: 6319\u20136326.","DOI":"10.1021\/jf201160a"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Milani P, Ambrosi G, Gammoh O, Blandini F, Cereda C. SOD1 and DJ-1 converge at Nrf2 pathway: a clue for antioxidant therapeutic potential in neurodegeneration. Oxid Med Cell Longev 2013; 2013: 836760.","DOI":"10.1155\/2013\/836760"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36 Col\u00edn-Gonz\u00e1lez AL, Luna-L\u00f3pez A, K\u00f6nigsberg M, Ali SF, Pedraza-Chaverri J, Santamar\u00eda A. Early modulation of the transcription factor Nrf2 in rodent striatal slices by quinolinic acid, a toxic metabolite of the kynurenine pathway. Neuroscience 2014; 260: 130\u2013139.","DOI":"10.1016\/j.neuroscience.2013.12.025"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37 Garcia E, Santana-Mart\u00ednez R, Silva-Islas CA, et al. <i>S<\/i>-allyl cysteine protects against MPTP-induced striatal and nigral oxidative neurotoxicity in mice: participation of Nrf2. Free Radic Res 2014; 48: 159\u2013167.","DOI":"10.3109\/10715762.2013.857019"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38 Tob\u00f3n-Velasco JC, V\u00e1zquez-Victorio G, Mac\u00edas-Silva M, et al. <i>S<\/i>-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades. Free Radic Biol Med 2012; 53: 1024\u20131040.","DOI":"10.1016\/j.freeradbiomed.2012.06.040"}],"container-title":["Journal of Clinical Biochemistry and Nutrition"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:06:22Z","timestamp":1598400382000},"score":1,"resource":{"primary":{"URL":"http:\/\/jlc.jst.go.jp\/DN\/JST.JSTAGE\/jcbn\/14-39?lang=en&from=CrossRef&type=abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.3164\/jcbn.14-39","relation":{},"ISSN":["0912-0009","1880-5086"],"issn-type":[{"value":"0912-0009","type":"print"},{"value":"1880-5086","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}